Category: 66-71-7

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organometallic Chemistry called Preparation, reactivity and photoluminescence of copper(I) borohydride complexes with bis[(2-diphenylphosphino)phenyl] ether as chelating ligand, Author is Ferraro, Valentina; Castro, Jesus; Trave, Enrico; Bortoluzzi, Marco, which mentions a compound: 66-71-7, SMILESS is C1=CC3=C(C2=NC=CC=C12)N=CC=C3, Molecular C12H8N2, Reference of 1,10-Phenanthroline.

Bis[(2-diphenylphosphino)phenyl] ether (DPEphos) was used as chelating ligand to prepare the corresponding borohydride complex [Cu(κ2-BH4)(DPEphos)], whose structure was ascertained spectroscopically and by means of X-ray diffraction. The spectroscopic assignments related to the coordinated borohydride were confirmed by preparing the isotopologue [Cu(κ2-BD4)(DPEphos)]. Reaction of [Cu(κ2-BH4)(DPEphos)] with triflic acid afforded the dimer [Cu2(μ-BH4)(DPEphos)2][OTf] (OTf = triflate). The borohydride complexes exhibited appreciable blue emission upon excitation with UV light at room temperature [Cu(κ2-BH4)(DPEphos)] revealed to be a suitable precursor for the preparation of luminescent heteroleptic copper(I) complexes having general formula [Cu(NN̂)(DPEphos)]+ (NN̂ = 1,10-phenantroline, 2,9-dimethyl-1,10-phenantroline, 2,2′-bypiridine, 4,4′-dimethyl-2,2’bipyridine).

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 66-71-7, is researched, Molecular C12H8N2, about Egg white protein polymer: an affinity matrix for protease enrichment and isolation, the main research direction is egg white protein polymer affinity matrix protease enrichment isolation.Quality Control of 1,10-Phenanthroline.

Egg white was precipitated with acetone and crosslinked with glutaraldehyde. Protease specificity of the polymer was investigated with different types of proteases and non-protease proteins. Protein polymer effectively bound trypsin, papain and the different proteases from pancreatin. SDS-PAGE results and diffusion agar plate tests supported the protease-binding efficiency of the polymer. In conclusion, egg white protein polymer can specifically bind proteases and it is a convenient and cost-effective material for enrichment, isolation, and removal of proteases.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Molecular Structure called Synthesis, molecular modeling, and docking studies of a new pyridazinone-acid hydrazone ligand, and its nano metal complexes. Spectroscopy, thermal analysis, electrical properties, DNA cleavage, antitumor, and antimicrobial activities, Author is Abdelrahman, Maha S. A.; Omar, Fouz M.; Saleh, Akila A.; El-ghamry, Mosad A., which mentions a compound: 66-71-7, SMILESS is C1=CC3=C(C2=NC=CC=C12)N=CC=C3, Molecular C12H8N2, Related Products of 66-71-7.

New nano Co(II), Ni(II), Cu(II), Zn(II), Fe(III) complexes, and oxovanadium(IV), dioxouranium(VI) complexes of pyridazinone-acid hydrazone ligand, DCNHP (H2L), in addition of new mixed-ligand complexes using 8-HQ/or 1,10-phen as an auxiliary ligand (L’), were synthesized and characterized by different techniques. The ligand, H2L, acted as tridentate towards the metal ions in a mono-, and bis- deprotonated form. The complexes exhibited a variety of geometrical structures including octahedral, square pyramidal, and tetrahedral configurations. The results of TGA confirmed the thermal stability of the metal complexes. The X-ray diffractograms and TEM images confirmed that the particles of the studied compounds were situated in nano-range with spherical and stick-shaped. Mol. modeling studies indicated that the theor. data agree well with the exptl. results. The antimicrobial activity study showed enhancement in activity of the free ligand upon complexation. The results of antitumor screening indicated that all examined compounds displayed inhibition of Hepatocellular carcinoma cell line (HepG-2) viability. The ligand, H2L, and its nano Cu(II) complex 7 displayed strong antitumor activity with IC50 = 3.80 and 3.81μg/mL, resp. The DNA cleavage study revealed that no ability for the screened compounds to cleavage DNA, and they may be able to induce cellular death in cancer cells through the apoptosis pathway. The docking results suggesting strong interactions of both the ligand, H2L, and its Cu(II) complex 7 with the VEGFR-2 enzyme, these interactions are very similar to that of the known hepatocellular carcinoma (HCC) inhibitor, sorafenib (Nexavar) with the target enzyme, and indicating the effective inhibition of the studied compounds towards hepatocellular carcinoma. Moreover, the elec. conductivity study in solid-state revealed that the nano Cu(II) complex 7 displayed higher σac values than that for the free ligand, H2L, and the studied compounds act as semiconductors.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Science of the Total Environment called Efficient degradation of aqueous organic contaminants in manganese(II)/peroxymonosulfate system assisted by pyridine organic ligands, Author is Hu, Youyou; Sun, Siyu; Xu, Mengshan; Guo, Jialin; Li, Zhengkui, which mentions a compound: 66-71-7, SMILESS is C1=CC3=C(C2=NC=CC=C12)N=CC=C3, Molecular C12H8N2, Quality Control of 1,10-Phenanthroline.

Although manganese(II) is known to have no role in peroxymonosulfate (PMS) activation, through a series of sulfamethoxazole (SMX) oxidation experiments, we found that the addition of pyridine organic ligands can improve the catalytic activity and accelerate SMX oxidation For the organic ligands to be effective: the stability constant of the Mn(III) complex should be higher than that of the Mn(II) complex. A pos. correlation was observed between the SMX oxidation rate and Mn(II) concentration, and the maximum PMS utilization efficiency was achieved. Many shreds of evidence verified that neither •SO-4 nor •OH was associated with SMX oxidation The enhanced effect of phenanthroline on the Mn(II)/PMS system was attributed to the highly oxidative intermediate manganese species (Mn(V)), originating from the two-electron transfer reaction of complexed Mn(III) and PMS. Notably, the main oxidizing species did not change (η-(PMSO2) ∼ 100%) regardless of the initial PMSO concentration or pH value. Addnl., the anal. of SMX degradation products revealed that the oxygen transfer oxidation pathway was dominant in the Mn(II)/phenanthroline/PMS system, while the N radical coupling pathway also contributed significantly to SMX oxidation This work offers new insights into the formation of high-valent manganese species and provides a potential strategy for applying low-concentration Mn(II) to wastewater treatment.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C12H8N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Long-lived cyclometalated iridium complexes: Synthesis, structure, DFT and photocatalytic aspects. Author is Laha, Paltan; Chandra, Falguni; Husain, Ahmad; Koner, Apurba Lal; Patra, Srikanta.

Herein, authors present synthesis, photophys. and photocatalytic aspects of four mononuclear luminescent iridium complexes ([1]+-[4]+) incorporating cyclometalating benzimidazole-based (L1 and L2) and phenanthroline pyrazine-based (L3-L5) ligands. Several anal. techniques were used for the characterization of the complexes. The structural elucidation of [2]+ and [3]+ using x-ray crystallog. show a distorted Oh structure with nitrogen donors of cyclometalating ligands are in trans-direction. All the complexes are emitting in the orange-red region and displayed moderately good quantum yield. The complexes have also shown moderately good luminescence lifetime (τ = 80-1900 ns) in different solvents. Importantly, the complex [3]+ exhibits comparative longer emission lifetime (τ = 1800 ns) in water at ambient condition. The complexes have shown moderately good photocatalytic efficacy towards azo dyes degradation in aqueous solution The mechanistic investigation suggests that in the presence of light in aqueous medium the complexes induce the generation of (HO•/(O•2-)) species which is responsible for the photodecomposition of azo dyes.

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Piperazine – Wikipedia,
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Khursheed, Salman; Tabassum, Sartaj; Arjmand, Farukh published the article 《Comprehensive biological {DNA/RNA binding profile, cleavage &cytotoxicity activity} of structurally well-characterized chromone-appended Cu(II)(L1-3)(phen) potential anticancer drug candidates》. Keywords: preparation copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; crystal structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; mol structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; DNA RNA interaction copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; anticancer activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; antimicrobial activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; cyclic voltammetry copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

A series of chromone-appended copper(II)(phen) complexes (1-3) having the general formulas [Cu(L1)(phen)(H2O)2(NO3)] 1, [Cu(L2)(phen)(NO3)] 2 and [Cu(L3)(phen)(NO3)] 3, where L1 = 3-formylchromone, L2 = 6-fluoro-3-formylchromone, L3 = 6-bromo-3-formylchromone and phen = 1,10-phenanthroline were prepared to examine the effect of halogen on structure activity relation. The mol. solid state structure of (1-3) was fully characterized by employing various spectroscopic techiques, single crystal x-ray diffraction studies and DFT B3LYP (gas phase) computations. Comparative in vitro binding studies of (1-3) with ct-DNA and tRNA were conducted by using a battery of optical {UV-visible, fluorecence and circular dichoric} and electrochem. methods, which implicated strong binding through noncovalent π-π stacking intercalative binding mode. The order of binding is 3 > 2 > 1 as determined by Kb and Ksv values with bromo analog 3 exhibiting the strongest binding affinity for both ct-DNA and tRNA nucleobases, however, underlining more avid predisposed binding with tRNA as compared to ct-DNA. The cleavage activity of (1-3) was studied by electrophoretic assay using pBR322 DNA and tRNA, which exhibited efficient DNA cleaving ability at low micro molar concentrations The cleavage process was mediated by an oxidative pathway involving ROS species viz., singlet oxygen (1O2) and superoxide anions(O•-2), with more pronounced cleaving ability of bromo analog 3 as compared to unsubstituted 1 and fluoro 2 analog derivatives Furthermore, time and concentration dependence of tRNA cleavage was also observed The cytotoxicity activity of tested drug candidates 2 and 3 were evaluated on a panel of human cancer cell lines, viz., MCF-7, MDA-MB-231, AW13516, SiHa and Hop-62 using SRB assay which validated bromo analog 3 and 2 as good anticancer agents, broadly against all the tested cancerous strains (with GI50 values < 10) except with AW13516, SiHa and Hop-62 (GI50 values were found in the range18.00-36.8). Here is just a brief introduction to this compound(66-71-7)Category: piperazines, more information about the compound(1,10-Phenanthroline) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Safety of 1,10-Phenanthroline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Spectroscopic studies on DNA interaction and anticancer activities of pharmacologically active pyrimidine derivative mixed ligand Co(II) and Ni(II) complexes. Author is Nagaraj, Revathi; Murugesan, Sankarganesh; Jeyaraj, Dhaveethu Raja; Arumugam, Sakthivel; Shunmugasundaram, Gurusamy; Radhakrishnan, Nandini Asha.

This article reports the synthesis and its structural elucidation of pyrimidine based mixed ligand complexes [CoL(phen)](OAc) (1), [CoL(bpy)](OAc) (2), [NiL(phen)](OAc) (3) and [NiL(bpy)](OAc) (4), where, HL = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl-4-nitrophenol, (phen) =1,10-phenanthroline, (bpy) = 2,2′-bipyridine and OAc = acetate. The prepared complexes are structurally pigeonholed by anal. and spectroscopic techniques. The hypothesized structure of prepared complexes has a square planar shape. This article deals with the spectroscopic, viscometric, and theor. investigation of binding between synthesized compounds and calf-thymus DNA (CT DNA). Spectroscopic (UV-Visible absorption and fluorescence) and viscometric measurements in combination with the mol. docking data reveal that produced compounds bind to DNA double helix in an intercalation mode. According to the in vitro anticancer activity data against various cancer cell lines (MCF-7, HeLa and HEp2), complexes 1-4 exhibit a modest anticancer impact. Investigation of the antioxidant property of prepared compounds showed that complexes 1-4 have a more antioxidant nature than Schiff base. A significant inhibition activity was predicted with complexes 1-4 against various bacterial inoculums typed as gram-pos. bacteria (S. aureus, S. pneumoniae, Stap. pneumoniae, B. subtilis) and gram-neg. bacteria (S. flexneri, S. typhi, K. pneumoniae, H. influenza) and various fungal inoculums such as A. niger, C. albicans, C. tropicalis, M. campestris. The chelating capacity of the Schiff base with Co(II) and Ni(II) ions indicated that complexes 1-4 are effective antimicrobial agents.

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SDS of cas: 66-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Two new Cu(II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity. Author is Xi, Yun-Hong; Yan, Xin; Bigdeli, Fahime; Zhang, Qianwen; Esrafili, Leili; Hanifehpour, Younes; Zhang, Wei-Bing; Hu, Mao-Lin; Morsali, Ali.

Two new Cu(II) complexes [Cu(bpy)2L1] BF4·CH3OH (Z3) and [Cu (phen)2L1] BF4·H2O (Z = 9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2′-Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines studied. The complexes were characterized by IR spectra, elemental anal., and x-ray crystallog. The interaction of the complexes with CT-DNA was studied by UV-visible absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC50 amount of 11.31 ± 0.74μM for Z = 9. The nature of the nitrogen-donor ligand is very effective in the anticancer activity of the complexes.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C12H8N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Long-lived cyclometalated iridium complexes: Synthesis, structure, DFT and photocatalytic aspects. Author is Laha, Paltan; Chandra, Falguni; Husain, Ahmad; Koner, Apurba Lal; Patra, Srikanta.

Herein, authors present synthesis, photophys. and photocatalytic aspects of four mononuclear luminescent iridium complexes ([1]+-[4]+) incorporating cyclometalating benzimidazole-based (L1 and L2) and phenanthroline pyrazine-based (L3-L5) ligands. Several anal. techniques were used for the characterization of the complexes. The structural elucidation of [2]+ and [3]+ using x-ray crystallog. show a distorted Oh structure with nitrogen donors of cyclometalating ligands are in trans-direction. All the complexes are emitting in the orange-red region and displayed moderately good quantum yield. The complexes have also shown moderately good luminescence lifetime (τ = 80-1900 ns) in different solvents. Importantly, the complex [3]+ exhibits comparative longer emission lifetime (τ = 1800 ns) in water at ambient condition. The complexes have shown moderately good photocatalytic efficacy towards azo dyes degradation in aqueous solution The mechanistic investigation suggests that in the presence of light in aqueous medium the complexes induce the generation of (HO•/(O•2-)) species which is responsible for the photodecomposition of azo dyes.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Khursheed, Salman; Tabassum, Sartaj; Arjmand, Farukh published the article 《Comprehensive biological {DNA/RNA binding profile, cleavage &cytotoxicity activity} of structurally well-characterized chromone-appended Cu(II)(L1-3)(phen) potential anticancer drug candidates》. Keywords: preparation copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; crystal structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; mol structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; DNA RNA interaction copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; anticancer activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; antimicrobial activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; cyclic voltammetry copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

A series of chromone-appended copper(II)(phen) complexes (1-3) having the general formulas [Cu(L1)(phen)(H2O)2(NO3)] 1, [Cu(L2)(phen)(NO3)] 2 and [Cu(L3)(phen)(NO3)] 3, where L1 = 3-formylchromone, L2 = 6-fluoro-3-formylchromone, L3 = 6-bromo-3-formylchromone and phen = 1,10-phenanthroline were prepared to examine the effect of halogen on structure activity relation. The mol. solid state structure of (1-3) was fully characterized by employing various spectroscopic techiques, single crystal x-ray diffraction studies and DFT B3LYP (gas phase) computations. Comparative in vitro binding studies of (1-3) with ct-DNA and tRNA were conducted by using a battery of optical {UV-visible, fluorecence and circular dichoric} and electrochem. methods, which implicated strong binding through noncovalent π-π stacking intercalative binding mode. The order of binding is 3 > 2 > 1 as determined by Kb and Ksv values with bromo analog 3 exhibiting the strongest binding affinity for both ct-DNA and tRNA nucleobases, however, underlining more avid predisposed binding with tRNA as compared to ct-DNA. The cleavage activity of (1-3) was studied by electrophoretic assay using pBR322 DNA and tRNA, which exhibited efficient DNA cleaving ability at low micro molar concentrations The cleavage process was mediated by an oxidative pathway involving ROS species viz., singlet oxygen (1O2) and superoxide anions(O•-2), with more pronounced cleaving ability of bromo analog 3 as compared to unsubstituted 1 and fluoro 2 analog derivatives Furthermore, time and concentration dependence of tRNA cleavage was also observed The cytotoxicity activity of tested drug candidates 2 and 3 were evaluated on a panel of human cancer cell lines, viz., MCF-7, MDA-MB-231, AW13516, SiHa and Hop-62 using SRB assay which validated bromo analog 3 and 2 as good anticancer agents, broadly against all the tested cancerous strains (with GI50 values < 10) except with AW13516, SiHa and Hop-62 (GI50 values were found in the range18.00-36.8). Here is just a brief introduction to this compound(66-71-7)Category: piperazines, more information about the compound(1,10-Phenanthroline) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics