Category: 66-71-7

Safety of 1,10-Phenanthroline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Spectroscopic studies on DNA interaction and anticancer activities of pharmacologically active pyrimidine derivative mixed ligand Co(II) and Ni(II) complexes. Author is Nagaraj, Revathi; Murugesan, Sankarganesh; Jeyaraj, Dhaveethu Raja; Arumugam, Sakthivel; Shunmugasundaram, Gurusamy; Radhakrishnan, Nandini Asha.

This article reports the synthesis and its structural elucidation of pyrimidine based mixed ligand complexes [CoL(phen)](OAc) (1), [CoL(bpy)](OAc) (2), [NiL(phen)](OAc) (3) and [NiL(bpy)](OAc) (4), where, HL = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl-4-nitrophenol, (phen) =1,10-phenanthroline, (bpy) = 2,2′-bipyridine and OAc = acetate. The prepared complexes are structurally pigeonholed by anal. and spectroscopic techniques. The hypothesized structure of prepared complexes has a square planar shape. This article deals with the spectroscopic, viscometric, and theor. investigation of binding between synthesized compounds and calf-thymus DNA (CT DNA). Spectroscopic (UV-Visible absorption and fluorescence) and viscometric measurements in combination with the mol. docking data reveal that produced compounds bind to DNA double helix in an intercalation mode. According to the in vitro anticancer activity data against various cancer cell lines (MCF-7, HeLa and HEp2), complexes 1-4 exhibit a modest anticancer impact. Investigation of the antioxidant property of prepared compounds showed that complexes 1-4 have a more antioxidant nature than Schiff base. A significant inhibition activity was predicted with complexes 1-4 against various bacterial inoculums typed as gram-pos. bacteria (S. aureus, S. pneumoniae, Stap. pneumoniae, B. subtilis) and gram-neg. bacteria (S. flexneri, S. typhi, K. pneumoniae, H. influenza) and various fungal inoculums such as A. niger, C. albicans, C. tropicalis, M. campestris. The chelating capacity of the Schiff base with Co(II) and Ni(II) ions indicated that complexes 1-4 are effective antimicrobial agents.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

SDS of cas: 66-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Two new Cu(II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity. Author is Xi, Yun-Hong; Yan, Xin; Bigdeli, Fahime; Zhang, Qianwen; Esrafili, Leili; Hanifehpour, Younes; Zhang, Wei-Bing; Hu, Mao-Lin; Morsali, Ali.

Two new Cu(II) complexes [Cu(bpy)2L1] BF4·CH3OH (Z3) and [Cu (phen)2L1] BF4·H2O (Z = 9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2′-Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines studied. The complexes were characterized by IR spectra, elemental anal., and x-ray crystallog. The interaction of the complexes with CT-DNA was studied by UV-visible absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC50 amount of 11.31 ± 0.74μM for Z = 9. The nature of the nitrogen-donor ligand is very effective in the anticancer activity of the complexes.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C12H8N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Long-lived cyclometalated iridium complexes: Synthesis, structure, DFT and photocatalytic aspects. Author is Laha, Paltan; Chandra, Falguni; Husain, Ahmad; Koner, Apurba Lal; Patra, Srikanta.

Herein, authors present synthesis, photophys. and photocatalytic aspects of four mononuclear luminescent iridium complexes ([1]+-[4]+) incorporating cyclometalating benzimidazole-based (L1 and L2) and phenanthroline pyrazine-based (L3-L5) ligands. Several anal. techniques were used for the characterization of the complexes. The structural elucidation of [2]+ and [3]+ using x-ray crystallog. show a distorted Oh structure with nitrogen donors of cyclometalating ligands are in trans-direction. All the complexes are emitting in the orange-red region and displayed moderately good quantum yield. The complexes have also shown moderately good luminescence lifetime (τ = 80-1900 ns) in different solvents. Importantly, the complex [3]+ exhibits comparative longer emission lifetime (τ = 1800 ns) in water at ambient condition. The complexes have shown moderately good photocatalytic efficacy towards azo dyes degradation in aqueous solution The mechanistic investigation suggests that in the presence of light in aqueous medium the complexes induce the generation of (HO•/(O•2-)) species which is responsible for the photodecomposition of azo dyes.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Khursheed, Salman; Tabassum, Sartaj; Arjmand, Farukh published the article 《Comprehensive biological {DNA/RNA binding profile, cleavage &cytotoxicity activity} of structurally well-characterized chromone-appended Cu(II)(L1-3)(phen) potential anticancer drug candidates》. Keywords: preparation copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; crystal structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; mol structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; DNA RNA interaction copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; anticancer activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; antimicrobial activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; cyclic voltammetry copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

A series of chromone-appended copper(II)(phen) complexes (1-3) having the general formulas [Cu(L1)(phen)(H2O)2(NO3)] 1, [Cu(L2)(phen)(NO3)] 2 and [Cu(L3)(phen)(NO3)] 3, where L1 = 3-formylchromone, L2 = 6-fluoro-3-formylchromone, L3 = 6-bromo-3-formylchromone and phen = 1,10-phenanthroline were prepared to examine the effect of halogen on structure activity relation. The mol. solid state structure of (1-3) was fully characterized by employing various spectroscopic techiques, single crystal x-ray diffraction studies and DFT B3LYP (gas phase) computations. Comparative in vitro binding studies of (1-3) with ct-DNA and tRNA were conducted by using a battery of optical {UV-visible, fluorecence and circular dichoric} and electrochem. methods, which implicated strong binding through noncovalent π-π stacking intercalative binding mode. The order of binding is 3 > 2 > 1 as determined by Kb and Ksv values with bromo analog 3 exhibiting the strongest binding affinity for both ct-DNA and tRNA nucleobases, however, underlining more avid predisposed binding with tRNA as compared to ct-DNA. The cleavage activity of (1-3) was studied by electrophoretic assay using pBR322 DNA and tRNA, which exhibited efficient DNA cleaving ability at low micro molar concentrations The cleavage process was mediated by an oxidative pathway involving ROS species viz., singlet oxygen (1O2) and superoxide anions(O•-2), with more pronounced cleaving ability of bromo analog 3 as compared to unsubstituted 1 and fluoro 2 analog derivatives Furthermore, time and concentration dependence of tRNA cleavage was also observed The cytotoxicity activity of tested drug candidates 2 and 3 were evaluated on a panel of human cancer cell lines, viz., MCF-7, MDA-MB-231, AW13516, SiHa and Hop-62 using SRB assay which validated bromo analog 3 and 2 as good anticancer agents, broadly against all the tested cancerous strains (with GI50 values < 10) except with AW13516, SiHa and Hop-62 (GI50 values were found in the range18.00-36.8). Here is just a brief introduction to this compound(66-71-7)Category: piperazines, more information about the compound(1,10-Phenanthroline) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Safety of 1,10-Phenanthroline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Spectroscopic studies on DNA interaction and anticancer activities of pharmacologically active pyrimidine derivative mixed ligand Co(II) and Ni(II) complexes. Author is Nagaraj, Revathi; Murugesan, Sankarganesh; Jeyaraj, Dhaveethu Raja; Arumugam, Sakthivel; Shunmugasundaram, Gurusamy; Radhakrishnan, Nandini Asha.

This article reports the synthesis and its structural elucidation of pyrimidine based mixed ligand complexes [CoL(phen)](OAc) (1), [CoL(bpy)](OAc) (2), [NiL(phen)](OAc) (3) and [NiL(bpy)](OAc) (4), where, HL = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl-4-nitrophenol, (phen) =1,10-phenanthroline, (bpy) = 2,2′-bipyridine and OAc = acetate. The prepared complexes are structurally pigeonholed by anal. and spectroscopic techniques. The hypothesized structure of prepared complexes has a square planar shape. This article deals with the spectroscopic, viscometric, and theor. investigation of binding between synthesized compounds and calf-thymus DNA (CT DNA). Spectroscopic (UV-Visible absorption and fluorescence) and viscometric measurements in combination with the mol. docking data reveal that produced compounds bind to DNA double helix in an intercalation mode. According to the in vitro anticancer activity data against various cancer cell lines (MCF-7, HeLa and HEp2), complexes 1-4 exhibit a modest anticancer impact. Investigation of the antioxidant property of prepared compounds showed that complexes 1-4 have a more antioxidant nature than Schiff base. A significant inhibition activity was predicted with complexes 1-4 against various bacterial inoculums typed as gram-pos. bacteria (S. aureus, S. pneumoniae, Stap. pneumoniae, B. subtilis) and gram-neg. bacteria (S. flexneri, S. typhi, K. pneumoniae, H. influenza) and various fungal inoculums such as A. niger, C. albicans, C. tropicalis, M. campestris. The chelating capacity of the Schiff base with Co(II) and Ni(II) ions indicated that complexes 1-4 are effective antimicrobial agents.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

SDS of cas: 66-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Two new Cu(II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity. Author is Xi, Yun-Hong; Yan, Xin; Bigdeli, Fahime; Zhang, Qianwen; Esrafili, Leili; Hanifehpour, Younes; Zhang, Wei-Bing; Hu, Mao-Lin; Morsali, Ali.

Two new Cu(II) complexes [Cu(bpy)2L1] BF4·CH3OH (Z3) and [Cu (phen)2L1] BF4·H2O (Z = 9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2′-Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines studied. The complexes were characterized by IR spectra, elemental anal., and x-ray crystallog. The interaction of the complexes with CT-DNA was studied by UV-visible absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC50 amount of 11.31 ± 0.74μM for Z = 9. The nature of the nitrogen-donor ligand is very effective in the anticancer activity of the complexes.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Shu-Ju; Zhang, Zhi-Qing; Jiang, Yi-Hui; Xiong, Gang; You, Li-Xin; Ding, Fu; Dragutan, Ileana; Dragutan, Valerian; Sun, Ya-Guang researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Name: 1,10-Phenanthroline.They published the article 《Versatile monometallic coordination polymers constructed from 4,4′-thiobis(methylene)bibenzoic acid and 1,10-phenanthroline. Synthesis, structure, magnetic and luminescence properties》 about this compound( cas:66-71-7 ) in Inorganica Chimica Acta. Keywords: preparation monometallic transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex; crystal structure transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex; thermal decomposition transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex; fluorescence transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex; magnetic property transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex. We’ll tell you more about this compound (cas:66-71-7).

Four novel mononuclear coordination polymers [Co(tmba)(phen)(H2O)0.5]n (1), [Mn(tmba)(phen)]n (2), [Zn(tmba)(phen)]n (3) and [Cd(tmba)(phen)(H2O)]n (4), H2tmba = 4,4′-thiobis(methylene)bibenzoic acid, phen = 1,10-phenanthroline, were synthesized under hydrothermal conditions and characterized by single crystal X-ray diffraction, powder X-ray diffraction, IR spectroscopy, and TGA. Single crystal X-ray diffraction showed that compounds 1, 3 and 4 build 1D chains whereas complex 2 displays a 2D layer configuration. Magnetic susceptibility measurements indicate that compound 1 exhibits the coexistence of spin-orbit coupling and antiferromagnetic interaction in the binuclear Co(II) center. Compound 2 manifests an antiferromagnetic interaction within the Mn(II)-carboxyl chain. Moreover, based on the solid state emission spectra of compounds 3 and 4, and of H2tmba and phen, relevant fluorescence properties were studied.

As far as I know, this compound(66-71-7)Name: 1,10-Phenanthroline can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Leng, Wancong; Cui, Leilei; Liu, Yang; Gong, Yun published the article 《MOF-Derived MnV2O4/C Microparticles with Graphene Coating Anchored on Graphite Sheets: Oxygen Defect Engaged High Performance Aqueous Zinc-Ion Battery》. Keywords: metal organic framework manganese vanadium oxide zinc ion battery.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).SDS of cas: 66-71-7. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

By annealing [Mn(phen)H2O][V2O6] (phen = 1,10-phenanthroline) in the presence of graphite template, MnV2O4 /C microparticles are obtained, in which MnV2O4 particles with one-layer or few-layer coating of graphene are anchored on the graphite sheets. The optimal sample, MnV2O4(p)/C-700 with a high carbon content (35.3 at %) can deliver a large specific capacity of 410 mAh g-1 at 0.1 A g-1 with a high capacity retention of 94.3 % over 1000 discharge/charge cycles at 20 A g-1 as cathode in zinc-ion battery. Ex situ X-ray diffraction, SEM, energy-dispersive X-ray spectra, as well as elemental mappings and XPS of MnV2O4(p)/C-700 discern the partial phase transformation mechanism of MnV2O4→Zn3(OH)2V2O7(H2O)2 during discharge/charge process. It is because the rich oxygen defects of MnV2O4 can improve elec. conductivity, favor the electron transfer from V→Mn/O, thus facilitate the binding of Zn2+, and the captured Zn2+ cannot be extracted, as evidenced by d. functional theory calculations Furthermore, it is found that O-deficiency can capture the water shell from the hydrated Zn2+, then the dehydrated Zn2+ is easy to insert into MnV2O4 with lower migration barrier of Zn2+ (0.84 eV), leading to the structural reversibility of MnV2O4 in cycling test.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,10-Phenanthroline( cas:66-71-7 ) is researched.Synthetic Route of C12H8N2.Jannapu Reddy, Raju; Waheed, Md.; Haritha Kumari, Arram; Rama Krishna, Gamidi published the article 《Interrupted CuAAC-Thiolation for the Construction of 1,2,3-Triazole-Fused Eight-Membered Heterocycles from O-/N-Propargyl derived Benzyl Thiosulfonates with Organic Azides》 about this compound( cas:66-71-7 ) in Advanced Synthesis & Catalysis. Keywords: benzoxathiocino benzothiazocino triazole preparation; propargyl benzyl thiosulfonate organic azide tandem cycloaddition thiolation. Let’s learn more about this compound (cas:66-71-7).

A copper(I)-catalyzed interrupted click-sulfenylation of O-/N-propargyl benzyl thiosulfonates with organic azides has been disclosed. The unified CuAAC-thiolation provides a wide range of triazole-fused eight-membered heterocycles in good to high (51-94%) yields under mild reaction conditions. Moreover, a three-component reaction is also achieved involving O-/N-propargyl benzyl thiosulfonates, benzyl bromide, and sodium azide to deliver fused-triazoles in 61-74% yields. From a synthetic point of view, the present protocol has been demonstrated at gram-scale reactions. A plausible mechanism is also proposed based on exptl. results and control experiments

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sun, Longjiang; Li, Qi; Zheng, Mang; Lin, Siying; Guo, Changliang; Luo, Laiyu; Guo, Shien; Li, Yuxin; Wang, Cheng; Jiang, Baojiang researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Product Details of 66-71-7.They published the article 《Efficient Suzuki-Miyaura cross-coupling reaction by loading trace Pd nanoparticles onto copper-complex-derived Cu/C-700 solid support》 about this compound( cas:66-71-7 ) in Journal of Colloid and Interface Science. Keywords: copper palladium nanocomposite catalyst preparation crystal structure; iodobenzene phenylboronic acid copper palladium catalyst Suzuki coupling; biphenyl preparation; Cu/C composite materials; Mononuclear copper complex; Suzuki-Miyaura cross-coupling (SMC) reaction; Synergistic effect; Trace Pd loading. We’ll tell you more about this compound (cas:66-71-7).

The development of efficient carbon-carbon cross-coupling catalysts with low noble metal amounts attracts much attention recently. Herein, a Cu/C-700/Pd nanocomposite is obtained by loading trace Pd2+ onto carbon support derived from a novel mononuclear copper complex, {[Cu(POP)2(Phen)2]BF4}. The as-prepared nanomaterial features the facial structure of highly dispersed copper phosphide nanoparticles as well as Pd nanoparticles via neighboring Cu-Pd sites. The Cu/C-700/Pd nanocomposite shows excellent catalytic activity (99.73%) and selectivity in Suzuki-Miyaura cross-coupling reaction, at trace Pd loading (0.43 mol%). Compared with the reported palladium nano catalysts, its advantages are proved. The appealing gateway to this stable, innovative and recyclability, Cu/C-700/Pd nanostructure recommends its beneficial utilization in carbon-carbon coupling and other environmentally friendly processes.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics