Category: 66-71-7

Nguyen, Hung Huy; Pham, Thu Thuy; Pham-Thi, Ngoc Oanh; Tran, Viet Hung; Le, Canh Dinh; Van Hoi, Bui; Trieu, Thi Nguyet; Pham, Chien Thang published the article 《Syntheses, structures, and anticancer activities of a series of trinuclear Cu(II) complexes with N-methylanthraniloyl(4-phenylthiosemicarbazide)》. Keywords: copper methylanthraniloyphenylthiosemicarbazide complex preparation anticancer; crystal structure copper methylanthraniloyphenylthiosemicarbazide complex.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Synthetic Route of C12H8N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

A series of trinuclear Cu(II) complexes with N-methylanthraniloyl(4-phenylthiosemicarbazide) (H2L) were successfully prepared and structurally determined The organic ligand H2L readily reacts with Cu(ClO4)2·6H2O and CuCl2·2H2O in DMF under formation of trinuclear complexes with the compositions of [Cu3(L)2(HCOO)2] (1) and [Cu3(L)2Cl2] (2), resp. Similar reaction with [Cu(phen)Cl2] gives rise to a trinuclear complex [Cu3(L)2(phen)]Cl2 (3a), which is alternatively prepared by a simple method including a simultaneous reaction of CuCl2·2H2O with H2L, o-phenanthroline and pyridine in CH2Cl2/MeOH. The compound [Cu3(L)2(phen)](PF6)2 (3b) is isolated from a analogous reaction and subsequent work up with (n-Bu4N)(PF6). Such facile synthetic procedure is successfully applied in preparation of structurally related product [Cu3(L)2(bpy)](PF6)2 (4). In all trinuclear complexes, the deprotonated organic compound L2- serves as bridging ligands with (N-amine, N1, S) and (O, N2) donor sets. The ligand H2L, 1 and 2 show almost no antiproliferative effects on the human MCF7 breast and HepG2 liver cancer cells. Surprisingly, 3 and 4 with IC50 values in the range of 1.37-10.24μM for MCF7 and 1.64-8.54μM for HepG2 exhibit significantly higher cytotoxicity than cisplatin under the same conditions.

From this literature《Syntheses, structures, and anticancer activities of a series of trinuclear Cu(II) complexes with N-methylanthraniloyl(4-phenylthiosemicarbazide)》,we know some information about this compound(66-71-7)Synthetic Route of C12H8N2, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 1,10-Phenanthroline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Micro-/Mesoporous Fluorescent Polymers and Devices for Visual Pesticide Detection with Portability, High Sensitivity, and Ultrafast Response.

The excess residue of pesticides in crops, soil, and water continues to be a widespread concern due to the threat to human health and food safety. With the aim to develop highly sensitive sensing materials and portable detection devices, two dicarbazole-based fluorescent micro-/mesoporous polymers (JYs) with a larger sp. surface area and pore sizes ranging from 1.1 to 34.2 nm are synthesized. The Stern-Volmer constants of JY fluorescence quenching for imidacloprid (50,063 M-1) exceed 23-51 times those of the reported porous organic polymers (980-2173 M-1). Of particular interest is the observation that JYs show rapid fluorescence response (2 s) and ultralow detection limit (30 ppb) for imidacloprid in water medium. The pronounced chemsensing property is attributed to the synergistic role of the hierarchical pore structure, large π-conjugation of chromophore groups, and strong inner filter effect between the polymer and imidacloprid mol. Moreover, the pesticide detection of JYs exhibits good interference resistance in complicated service environments such as the extract liquids of the apple peel and field soil as well as aqueous solutions of various cations and anions. Because of the portability, excellent reusability, and sensitive fluorescence response, the prepared JYs and detection devices have promising applications in the on-site monitoring and early warning of the pesticide residues.

From this literature《Micro-/Mesoporous Fluorescent Polymers and Devices for Visual Pesticide Detection with Portability, High Sensitivity, and Ultrafast Response》,we know some information about this compound(66-71-7)Recommanded Product: 1,10-Phenanthroline, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Nano cadmium(II)-benzyl benzothiazol-2-ylcarbamodithioate complexes: Synthesis, characterization, anti-cancer and antibacterial studies.Name: 1,10-Phenanthroline.

Benzyl benzothiazol-2-ylcarbamodithioate (BBCT) was used as a ligand for the synthesis of [Cd(BBCT)(PPh3)Cl]Cl (1), [Cd2(BBCT)2(μ-dppm)2]Cl4 (2), or [Cd(BBCT)(phosphine)]Cl2 (where phosphine is dppe (3), dppp (4), dppb (5)) and [Cd(BBCT)(amine)]Cl2 (where amine is bipy (6) or phen (7)). The characterizations (molar conductivity, elemental anal., IR spectra and 31P NMR, 1H NMR and 13C NMR spectra) prove that BBCT ligand behaves as a bidentate ligand through the N atom of thiazole ring group and S atom of thion group while the phosphines or amines ligands behave as bidentate ligand through the P atoms or N atoms, resp. Furthermore, the nanostructure of (1) and (7) was examined by SEM and the results demonstrate the presence of regular nanostructures. The complex (1) shows fiber-grip-like geometry with 85-110 nm while complex (7) shows spiny-flowers-like nanostructures with the flower-forming spines within the range of 80-190 nm. The antibacterial activity of the complexes (1, 2, 3, 6, 7) against S.Epidermidis, S. aureus (gram-pos.) and C.Freundii (gram-neg.) was examined using amikacin as a pos. control. However, all the complexes showed a high ability to inhibit the bacterial species studied, and the inhibition zone was better than that obtained with amikacin. Moreover, the anti-cancer activity of the complexes (1) and (7) against ovarian cancer cell was studied and the results show that both complexes gave cell viability values less than 6%.

From this literature《Nano cadmium(II)-benzyl benzothiazol-2-ylcarbamodithioate complexes: Synthesis, characterization, anti-cancer and antibacterial studies》,we know some information about this compound(66-71-7)Name: 1,10-Phenanthroline, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 66-71-7, is researched, Molecular C12H8N2, about Design, Synthesis, Bioanalytical, Photophysical and Chemo-phototherapeutic Studies of Heteroleptic Cu(II) Complexes, the main research direction is copper complex thermodn property anticancer mol docking.Product Details of 66-71-7.

A broad investigation has been paid to design an alternative metal-based anticancer drug, bearing metal ions other than platinum, with more target specificity. In this regard, Cu(II) complexes showed a remarkable intercalation binding property with DNA which have received much attention in the development of efficient anticancer drugs. A series of mononuclear ternary Cu(II) complexes A, B and C were prepared with H2L and auxiliary ligand. The synthesized H2L and corresponding complexes were characterized using various electroanal. and physicochem. techniques. The thermodn. parameters were calculated using Gibb′s-Helmholtz, Arrhenius and Eyring equations. Morphol., binding energies of core electrons and crystallog. nature of the metal complexes were evaluated by SEM, XPS and PXRD techniques. Binding studies of the metal complexes with CT-DNA were conducted by absorption, fluorescence and viscometric methods. The pBR322 cleavage, antioxidant and mol. docking studies revealed the potent biol. activity of title complexes. In-vitro cytotoxicity of these biol. active biomaterials tested against HeLa and MCF-7 by MTT assay and DAPI staining revealed their anticancer activity. Such results are supportive for advanced studies which would come through insight for their possible applications.

From this literature《Design, Synthesis, Bioanalytical, Photophysical and Chemo-phototherapeutic Studies of Heteroleptic Cu(II) Complexes》,we know some information about this compound(66-71-7)Product Details of 66-71-7, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C12H8N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease. Author is Thun-Hohenstein, Siegfried T. D.; Suits, Timothy F.; Malla, Tika R.; Tumber, Anthony; Brewitz, Lennart; Choudhry, Hani; Salah, Eidarus; Schofield, Christopher J..

The reactive organoselenium compound ebselen is being investigated for treatment of coronavirus disease 2019 (COVID-19) and other diseases. We report structure-activity studies on sulfur analogs of ebselen with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), employing turnover and protein-observed mass spectrometry-based assays. The results reveal scope for optimization of ebselen/ebselen derivative- mediated inhibition of Mpro, particularly with respect to improved selectivity.

From this literature《Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease》,we know some information about this compound(66-71-7)Electric Literature of C12H8N2, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Nguyen, Hung Huy; Pham, Thu Thuy; Pham-Thi, Ngoc Oanh; Tran, Viet Hung; Le, Canh Dinh; Van Hoi, Bui; Trieu, Thi Nguyet; Pham, Chien Thang published the article 《Syntheses, structures, and anticancer activities of a series of trinuclear Cu(II) complexes with N-methylanthraniloyl(4-phenylthiosemicarbazide)》. Keywords: copper methylanthraniloyphenylthiosemicarbazide complex preparation anticancer; crystal structure copper methylanthraniloyphenylthiosemicarbazide complex.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Synthetic Route of C12H8N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

A series of trinuclear Cu(II) complexes with N-methylanthraniloyl(4-phenylthiosemicarbazide) (H2L) were successfully prepared and structurally determined The organic ligand H2L readily reacts with Cu(ClO4)2·6H2O and CuCl2·2H2O in DMF under formation of trinuclear complexes with the compositions of [Cu3(L)2(HCOO)2] (1) and [Cu3(L)2Cl2] (2), resp. Similar reaction with [Cu(phen)Cl2] gives rise to a trinuclear complex [Cu3(L)2(phen)]Cl2 (3a), which is alternatively prepared by a simple method including a simultaneous reaction of CuCl2·2H2O with H2L, o-phenanthroline and pyridine in CH2Cl2/MeOH. The compound [Cu3(L)2(phen)](PF6)2 (3b) is isolated from a analogous reaction and subsequent work up with (n-Bu4N)(PF6). Such facile synthetic procedure is successfully applied in preparation of structurally related product [Cu3(L)2(bpy)](PF6)2 (4). In all trinuclear complexes, the deprotonated organic compound L2- serves as bridging ligands with (N-amine, N1, S) and (O, N2) donor sets. The ligand H2L, 1 and 2 show almost no antiproliferative effects on the human MCF7 breast and HepG2 liver cancer cells. Surprisingly, 3 and 4 with IC50 values in the range of 1.37-10.24μM for MCF7 and 1.64-8.54μM for HepG2 exhibit significantly higher cytotoxicity than cisplatin under the same conditions.

From this literature《Syntheses, structures, and anticancer activities of a series of trinuclear Cu(II) complexes with N-methylanthraniloyl(4-phenylthiosemicarbazide)》,we know some information about this compound(66-71-7)Synthetic Route of C12H8N2, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 1,10-Phenanthroline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Micro-/Mesoporous Fluorescent Polymers and Devices for Visual Pesticide Detection with Portability, High Sensitivity, and Ultrafast Response.

The excess residue of pesticides in crops, soil, and water continues to be a widespread concern due to the threat to human health and food safety. With the aim to develop highly sensitive sensing materials and portable detection devices, two dicarbazole-based fluorescent micro-/mesoporous polymers (JYs) with a larger sp. surface area and pore sizes ranging from 1.1 to 34.2 nm are synthesized. The Stern-Volmer constants of JY fluorescence quenching for imidacloprid (50,063 M-1) exceed 23-51 times those of the reported porous organic polymers (980-2173 M-1). Of particular interest is the observation that JYs show rapid fluorescence response (2 s) and ultralow detection limit (30 ppb) for imidacloprid in water medium. The pronounced chemsensing property is attributed to the synergistic role of the hierarchical pore structure, large π-conjugation of chromophore groups, and strong inner filter effect between the polymer and imidacloprid mol. Moreover, the pesticide detection of JYs exhibits good interference resistance in complicated service environments such as the extract liquids of the apple peel and field soil as well as aqueous solutions of various cations and anions. Because of the portability, excellent reusability, and sensitive fluorescence response, the prepared JYs and detection devices have promising applications in the on-site monitoring and early warning of the pesticide residues.

From this literature《Micro-/Mesoporous Fluorescent Polymers and Devices for Visual Pesticide Detection with Portability, High Sensitivity, and Ultrafast Response》,we know some information about this compound(66-71-7)Recommanded Product: 1,10-Phenanthroline, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Nano cadmium(II)-benzyl benzothiazol-2-ylcarbamodithioate complexes: Synthesis, characterization, anti-cancer and antibacterial studies.Name: 1,10-Phenanthroline.

Benzyl benzothiazol-2-ylcarbamodithioate (BBCT) was used as a ligand for the synthesis of [Cd(BBCT)(PPh3)Cl]Cl (1), [Cd2(BBCT)2(μ-dppm)2]Cl4 (2), or [Cd(BBCT)(phosphine)]Cl2 (where phosphine is dppe (3), dppp (4), dppb (5)) and [Cd(BBCT)(amine)]Cl2 (where amine is bipy (6) or phen (7)). The characterizations (molar conductivity, elemental anal., IR spectra and 31P NMR, 1H NMR and 13C NMR spectra) prove that BBCT ligand behaves as a bidentate ligand through the N atom of thiazole ring group and S atom of thion group while the phosphines or amines ligands behave as bidentate ligand through the P atoms or N atoms, resp. Furthermore, the nanostructure of (1) and (7) was examined by SEM and the results demonstrate the presence of regular nanostructures. The complex (1) shows fiber-grip-like geometry with 85-110 nm while complex (7) shows spiny-flowers-like nanostructures with the flower-forming spines within the range of 80-190 nm. The antibacterial activity of the complexes (1, 2, 3, 6, 7) against S.Epidermidis, S. aureus (gram-pos.) and C.Freundii (gram-neg.) was examined using amikacin as a pos. control. However, all the complexes showed a high ability to inhibit the bacterial species studied, and the inhibition zone was better than that obtained with amikacin. Moreover, the anti-cancer activity of the complexes (1) and (7) against ovarian cancer cell was studied and the results show that both complexes gave cell viability values less than 6%.

From this literature《Nano cadmium(II)-benzyl benzothiazol-2-ylcarbamodithioate complexes: Synthesis, characterization, anti-cancer and antibacterial studies》,we know some information about this compound(66-71-7)Name: 1,10-Phenanthroline, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 66-71-7, is researched, Molecular C12H8N2, about Design, Synthesis, Bioanalytical, Photophysical and Chemo-phototherapeutic Studies of Heteroleptic Cu(II) Complexes, the main research direction is copper complex thermodn property anticancer mol docking.Product Details of 66-71-7.

A broad investigation has been paid to design an alternative metal-based anticancer drug, bearing metal ions other than platinum, with more target specificity. In this regard, Cu(II) complexes showed a remarkable intercalation binding property with DNA which have received much attention in the development of efficient anticancer drugs. A series of mononuclear ternary Cu(II) complexes A, B and C were prepared with H2L and auxiliary ligand. The synthesized H2L and corresponding complexes were characterized using various electroanal. and physicochem. techniques. The thermodn. parameters were calculated using Gibb′s-Helmholtz, Arrhenius and Eyring equations. Morphol., binding energies of core electrons and crystallog. nature of the metal complexes were evaluated by SEM, XPS and PXRD techniques. Binding studies of the metal complexes with CT-DNA were conducted by absorption, fluorescence and viscometric methods. The pBR322 cleavage, antioxidant and mol. docking studies revealed the potent biol. activity of title complexes. In-vitro cytotoxicity of these biol. active biomaterials tested against HeLa and MCF-7 by MTT assay and DAPI staining revealed their anticancer activity. Such results are supportive for advanced studies which would come through insight for their possible applications.

From this literature《Design, Synthesis, Bioanalytical, Photophysical and Chemo-phototherapeutic Studies of Heteroleptic Cu(II) Complexes》,we know some information about this compound(66-71-7)Product Details of 66-71-7, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C12H8N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease. Author is Thun-Hohenstein, Siegfried T. D.; Suits, Timothy F.; Malla, Tika R.; Tumber, Anthony; Brewitz, Lennart; Choudhry, Hani; Salah, Eidarus; Schofield, Christopher J..

The reactive organoselenium compound ebselen is being investigated for treatment of coronavirus disease 2019 (COVID-19) and other diseases. We report structure-activity studies on sulfur analogs of ebselen with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), employing turnover and protein-observed mass spectrometry-based assays. The results reveal scope for optimization of ebselen/ebselen derivative- mediated inhibition of Mpro, particularly with respect to improved selectivity.

From this literature《Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease》,we know some information about this compound(66-71-7)Electric Literature of C12H8N2, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics