Category: 694499-26-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

General procedure: To amixture of substituted benzoic acid obtained in the last step (0.12 mmol) in 5mL DMF, 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate (HATU, 0.18 mmol), ethyldiisopropylamine (DIPEA, 0.24 mmol)and 4-((4-methylpiperazin-1-yl)methyl)-3- (trifluoromethyl)aniline (0.1 mmol)was added. The resulting mixture was stirred at room temperature overnight. Thenthe reaction was extracted with ethyl acetate, washed with brine, dried overanhydrous Na2SO4, filtered and concentrated to give thecrude product, which was further purified by column chromatography to affordthe final compounds.

694499-26-8, 694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Han, Mei; Li, Shan; Ai, Jing; Sheng, Rong; Hu, Yongzhou; Hu, Youhong; Geng, Meiyu; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5679 – 5684;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

694499-26-8, Step 1: Preparation of N-(3-iodo-4-methylphenyl)-N’-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]urea Triphosgene (1.04 g, 3.5 mmol) and ClCH2CH2Cl (20 ml) were added into a 100 ml round-bottomed flask, and stirred at room temperature until triphosgene was completely dissolved and the system appears colorless and transparent. The reaction system was placed in an ice-salt bath and stirred, 3-iodo-4-methylaniline (1.64 g, 7 mmol) in ClCH2CH2Cl solution (20 ml) was slowly added dropwise, and the system appears yellow milky. After the addition was complete, the mixture was stirred at room temperature for 4 hours. Et3N (1.43 g, 14 mmol) was added and stirred at room temperature for 0.5 hour. 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline (1.87 g, 7 mmol) was added and stirred at room temperature for 16 hours. The volatiles were removed by distillation under reduced pressure, and the residue was extracted with ethyl acetate (30 ml x 3) and H2O (30 ml). The organic phases were combined, dried over anhydrous Na2SO4, concentrated, and purified by column chromatography, to give a yellow solid. ESI-MS m/z: [M+H]+= 533.2, calculated: 533.3.

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; WANG, Yong; ZHAO, Liwen; ZHANG, Di; WU, Feng; BI, Sheng; GAO, Yiping; CHEN, Hongbin; CHEN, Hongyan; ZHANG, Cang; NAN, Yang; LIU, Yang; EP2927232; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,694499-26-8

A solution of 740 mg (2.71 mMol) of 4- (4-METHYL-PIPERAZIN-1-YLMETHYL)-3- trifluoromethyl] benzenamine in 12.5 ml CH2CI2 and 2.5 ML pyridine is cooled in an ice-bath under N2-atmosphere. Then a solution of 375 PL (2.85 MMOL) of 2-nitrobenzoyl chloride (Fluka, Buchs, Switzerland) in 12.5 ml CH2CI2 is added dropwise. After 30 min, the resulting mixture is diluted with EtOAc and 0.5 N HCI, the aqueous layer separated off and extracted with EtOAc. The organic phases are washed 3 times with 0.5 N HCI and then discarded. The combined aqueous phases are turned basic by the addition of saturated NA2CO3 solution and extracted with 3 portions of EtOAc. The organic phases are washed with brine, dried (NA2SO4) and CONCENTRATED IN VACUUO. COLUMN chromatography (SiO2 ; ETOAC X EtOAc/EtOH (+ 1 % ET3N) 97: 3) gives the title compound ; MS: [M+1] + = 423.

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/52884; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

694499-26-8, The compound prepared in step 2 above (25 mg, 0.07 mmol) was dissolved in DMF (1 ml), to which 4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (36 mg, 0.13 mmol) (AK Scientific Co., CatNo. AK-83227, CAS [694499-26-8]), EDC (25 mg, 0.13 mmol) and DMAP (16 mg, 0.13 mmol) were added, followed by stirring at 60 C. for 15 hours. The reaction mixture was cooled down to room temperature. The reaction mixture was diluted with ethyl acetate, which was washed with saturated sodium bicarbonate solution, water and brine. The organic layer was dried over MgSO4, filtered and then concentrated. The obtained residue was purified by preparative HPLC (0.1% TFA in water/acetonitrile). As a result, a target compound was obtained (21 mg, 42.5% yield). 1H NMR (400 MHz, Methanol-d4) delta 8.29 (td, 3H), 8.18 (d, 1H), 8.04 (dd, 1H), 7.98 (dd, 1H), 7.80 (d, 1H), 7.56 (d, 1H), 7.43-7.30 (m, 2H), 7.26 (d, 2H), 7.23-7.16 (m, 2H), 3.80 (s, 2H), 3.56-3.43 (m, 2H), 3.24-3.13 (m, 2H), 3.13-2.98 (m, 2H), 2.93 (s, 3H), 2.70 (s, 3H), 2.64-2.42 (m, 2H), 2.37 (s, 3H); MS m/z: 638[M+H]; HPLC tR5.89 min (method A)

694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION; Choi, Hwan Geun; Son, Jung Beom; Kim, Shinae; Lee, Seungyeon; Ko, Eunhwa; Cho, Joongheui; Kang, Seock Yong; Kim, So Young; Park, Jin-Hee; Ko, Yi Kyung; Ryu, Hee Yoon; Kim, Nam Doo; Kim, Hyunkyoung; Lee, Younho; Lee, Sun-Hwa; Kim, Dayea; Lee, Sun Joo; Hong, Seongho; Min, Sang Hyun; Lee, Sungwoo; Choi, Dong Kyu; Bae, Jae Hyun; Hong, Eunmi; Jang, Tae-ho; Song, Jaeyoung; Kim, Sangbum; Yoon, Suk Kyoon; (108 pag.)US2019/315738; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

Step 1: Preparation of 3-iodo-4-methyl-N-[4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylphenyl]benzamide 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline (2.27 g, 8.3 mmol), 3-iodo-4-methyl-benzoyl chloride (10 mmol), 15 ml tetrahydrofuran, and 10 ml triethylamine were added into a reactor and stirred at room temperature for 4 hours. After completion of the reaction, the resultant was washed with a saturated NaHCO3 solution, extracted with ethyl acetate and water, washed with a saturated NaCl solution, dried over anhydrous Na2SO4. The solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography, to give a yellow oily matter. 1H NMR (500 MHz, CDCl3) delta: 8.39(s,1 H,N-H), 8.29(s,1 H,Ar-H), 7.88(d, 1 H, Ar-H), 7.86(s, 1 H, Ar-H), 7.75(d, 1 H, Ar-H), 7.73(d, 1 H, Ar-H), 7.28(d, 1 H, Ar-H), 3.62(s, 2H, PhCH2), 2.60(b, 8H, 4x-CH2), 2.47(s, 3H,-CH3), 2.31 (s, 3H,-CH3)., 694499-26-8

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; WANG, Yong; ZHAO, Liwen; ZHANG, Wenping; CHEN, Hongyan; BI, Sheng; GAO, Yiping; CHEN, Hongbin; LIU, Yang; XU, Xin; ZHANG, Cang; EP2896620; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

694499-26-8, General procedure: To a solution of 3-iodo-4-methylbenzoyl chloride obtained above in dry DCM (10mL) at 0C was added Et3N (0.28mL, 2.0mmol) and 4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) aniline (328mg, 1.2mmol). The mixture was stirred at room temperature for 5h, and then the solvent was removed under reduced pressure. The residue was purified by using column chromatography to afford the corresponding product 6-1 (439mg, 2 steps yield: 85%).

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics