Category: 694499-26-8

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

After taking the two 50mL round bottom flask was added sequentially aniline compound 5 (1.10mmol), NaNO2 (2.21mmol), ultrapure water (20 mL), the system was cooled to 0 deg.] C, was slowly added dropwise HCl (3.30mmol) in 5mL aqueous solution The After the addition, maintain the temperature of the reaction system continue to react 1.5h. It was then slowly added dropwise an aqueous solution of NaN3 (1.32mmol). After the addition was complete, maintainingThe reaction temperature of the reaction system, 3h, TLC monitored the reaction. After completion of the reaction, a saturated NaHCO3 solution was added 20mL, extracted with ethyl acetate 30mL ¡Á 2, combined organic phases were dried over anhydrous Na2SO4, and concentrated to give azide 6 directly administered next.

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tianjin International Bio-pharmaceutical Joint Institute; Rao Zihe; Bai Cuigai; Yang Cheng; Chen Yue; Li Huiying; Wang Lei; Gao Yuan; Yang Juan; Sun Tao; Zhong Chuanke; (26 pag.)CN106749278; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

To the round bottom flask was added 3-iodo-4-methyl-benzoic acid (2.62 g, lOmmol), 10 ml of thionyl chloride and refluxed at 78 C for 4 hours. The rotary evaporator removed the volatile material to give 3-iodo- 4-methyl-benzoyl chloride. A solution of 4- (4-methylpiperazin-1-ylmethyl) -3-trifluoromethylaniline (2.27 g, 8.3 mmol), 3-iodo-4-methyl-benzoyl chloride (LOmmol), 15 ml of tetrahydrofuran, 10 ml of triethylamine and stirred at room temperature for 4 hours. Washed with saturated NaHC03 solution, extracted with ethyl acetate and water, washed with saturated NaCl solution, dried over anhydrous Na2S04, and the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column to give the title compound.

694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; NANJING SANHOME PHARMACEUTICAL CO., LTD.; WANG, YONG; ZHAO, LIWEN; CHEN, HONGYAN; ZHANG, DI; XU, XIN; ZHANG, CANG; ZHANG, HONGXING; (9 pag.)CN103664951; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics