Category: 697305-48-9

697305-48-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.697305-48-9,1-(4-Fluorophenyl)piperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of ethyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate methanesulfonate 4 (606 mg, 1.8 mmol) and CDI (476 mg, 2.9 mmol) in MeCN (10 mL) was added dropwise DIEPA (0.67 mL) and stirred at 0 C for 30 min. 8a (410 mg, 1.8 mmol) and DIPEA (0.35 mL) was added to the mixture, and stirred ar room temperature overnight. The mixture was added sat. NaHCO3 aq., and extracted with AcOEt. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The residue was purified by column chromatography to give 6a as a amorphous solid. The obtained material was dissolved in EtOH (5 mL) and was added dropwise 4 N NaOH (1.4 mL). The resulting mixture was stirred room temperature overnight. After evaporation of the solvent, the residue was acidified with 1 N HCl and the resulting precipitate was collected by filtration, washed with H2O to give 7a (630 mg, 81%) as a colorless solid.

697305-48-9 1-(4-Fluorophenyl)piperazin-2-one hydrochloride 67085022, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Banno, Yoshihiro; Sasaki, Shigekazu; Kamata, Makoto; Kunitomo, Jun; Miyamoto, Yasufumi; Abe, Hidenori; Taya, Naohiro; Oi, Satoru; Watanabe, Masanori; Urushibara, Tomoko; Hazama, Masatoshi; Niwa, Shin-ichi; Miyamoto, Saku; Horinouchi, Akira; Kuroshima, Ken-ichi; Amano, Nobuyuki; Matsumoto, Shin-ichi; Matsunaga, Shinichiro; Bioorganic and Medicinal Chemistry; vol. 25; 21; (2017); p. 5995 – 6006;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.697305-48-9,1-(4-Fluorophenyl)piperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of 3-chloro-6-(1 H-pyrazol-4-yl)-8-(trifluoromethyl)imidazo[1 ,2- a]pyridine-2-carboxylic acid (0.097 g, 0.295 mmol), 1-(4-fluorophenyl)-2-piperazinone hydrochloride (0.068 g, 0.295 mmol), DIPEA (0.154 mL, 0.884 mmol) and HATU (0.135 g, 0.354 mmol) in DMF (2 mL) was stirred at room temperature for one hour. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried over sodium sulfate and concentrated. The residue was purified by reverse phase HPLC (acetonitrile:water with 0.1 % formic acid) to give the title compound (0.045 g, 29%) as a white solid. 1H NMR (400 MHz, DMSO-c 6) delta ppm 13.19 (br. s., 1 H) 8.87 (s, 1 H) 8.59 (m, 1 H) 8.24 (m, 2 H) 7.33 – 7.61 (m, 2 H) 7.26 (t, 2 H) 4.69 (s, 1 H) 4.42 (m, 1 H) 4.13 – 4.29 (m, 1 H) 3.99 – 4.13 (m, 1 H) 3.81 (m, 2 H). ES-LCMS m/z: 507 (M+1 )., 697305-48-9

The synthetic route of 697305-48-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; PEAT, Andrew, James; PRICE, Daniel, J.; SHOTWELL, John, Brad; TAI, Vincent; ZHANG, Huichang; WO2011/41713; (2011); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

697305-48-9, 1-(4-Fluorophenyl)piperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

697305-48-9, A mixture of 3-chloro-6-(3-furanyl)-8-(trifluoromethyl)imidazo[1 ,2-a]pyridine- 2-carboxylic acid potassium salt (0.107 g, 0,290 mmol), 1-(4-f.uorophenyl)-2-piperazinone hydrochloride (0.067 g, 0.290 mmol), DIPEA (0.152 mL, 0.871 mmol) and HATU (0.133 g, 0.349 mmol) in DMF (2 mL) was stirred at room temperature for one hour. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried over sodium sulfate and concentrated. The residue was purified by reverse phase HPLC (acetonitrile:water with 0.1 % formic acid) to give the title compound (0.059 g, 36%) as an off-white solid. H NMR (400 MHz, DMSO-c/6) delta ppm 8.71 – 9.06 (m, 1 H) 8.58 (s, 1 H) 8.08 – 8.33 (m, 1 H) 7.86 (s, 1 H) 7.40 – 7.48 (m, 2 H) 7.35 (s, 1 H) 7.26 (t, 2 H) 4.68 (s, 1 H) 4.42 (s, 1 H) 4.22 (br. s., 1 H) 4.05 (br. s., 1 H) 3.76 – 3.89 (m, 2 H). ES-LCMS m/z: 507 (M+ ).

697305-48-9 1-(4-Fluorophenyl)piperazin-2-one hydrochloride 67085022, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; PEAT, Andrew, James; PRICE, Daniel, J.; SHOTWELL, John, Brad; TAI, Vincent; ZHANG, Huichang; WO2011/41713; (2011); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics