Category: 70261-82-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

Preparation of 2,4-dihydroxy-5-isopropyl-N-(4-((4-methylpiperazin-l- yl)methyl)phenyl)- benzothioamide (K): [00447] To a stirred solution of 5.0g (21.89mmols) of 2,4-dihydroxy-5- isopropylbenzodithioic acid (J) in 30mL of anhydrous DMF was added 5.9g (70.07mmols) of NaHC03 followed by 2.55g (21.89mmols) of sodium 2-chloroacetate and the mixture was heated at 80 C for lh. 4-((4-methylpiperazin-l-yl)methyl)aniline (4.3g, 20.80mmols) was then added portion wise and the mixture was further heated at 80 C for 2h. The reaction mixture was then cooled, lOOmL of ice-water was added and the pH of the mixture was brought down to approx. 7 using saturated NH4CI solution. The resultant precipitate was then filtered, dried and redissolved in 9:1 ethyl acetate methanol, dried over Na2S04 and concentrated to afford compound K (7.8g) as yellow solid which was carried to next step without purification., 70261-82-4

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Patent; SYNTA PHARMACEUTICALS CORP.; CHIMMANAMADA, Dinesh, U.; YING, Weiwen; WO2013/152206; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

70261-82-4, To Example 55D (75 mg, 0.198 mmol) and m-chloroperoxybenzoic acid (53.3 mg, 0.238 mmol) was added 2 mL dichlormethane. The reaction was stirred for 15 minutes when 4-((4-methylpiperazin-1-yl)methyl)aniline (48.9 mg, 0.238 mmol) followed by trifluoroacetic acid (0.031 ml, 0.397 mmol). The mixture was stirred at 50 C. for 1 hour, and at room temperature overnight. The mixture was diluted with ethyl acetate, washed with saturated aqueous NaHCO3, water, and brine, dried over MgSO4, filtered and concentrated. The crude material was dissolved in methanol, and treated with 2N HCl in diethyl ether for 1 hour. The mixture was diluted with diethyl ether and filtered. The solid was triturated with 1:1 DMSO/methanol solution, diluted with ethyl acetate, filtered, and dried over high-vacuum to provide the title compound. 1H NMR (501 MHz, DMSO-d6) delta 2.53 (s, 2H) 2.78 (s, 2H) 3.15 (s, 3H) 3.19-3.50 (m, 4H) 3.91 (s, 2H) 7.09 (d, J=1.18 Hz, 1H) 7.47 (d, J=7.58 Hz, 2H) 7.55-7.64 (m, 1H) 7.66-7.74 (m, 2H) 7.80 (d, J=1.66 Hz, 1H) 7.86 (d, J=8.06 Hz, 2H) 9.16 (s, 1H). MS (ESI+) m/z 534.9 (M+H)+.

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; US2012/220572; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

38. 159 mg of 4-{[4-((4-methylpiperazin-1-yl)methyl)phenyl]hydrazono}-4H-pyrazole-3,5-diamine was prepared in two steps starting with 205 mg (1.00 mmol) of 4-(4-methylpiperazin-1-yl)methylphenylamine. Yield 50.6%. MS (m/z, ES+): 315 (M+1, 20%). 1H NMR (ppm, 200 MHz, DMSO-d6) delta 2.1 (s, 3H), 2.2-2.5 (br m, 4H), 3.15-3.25 (br m, 4H), 3.45 (s, 2H), 5.5-6.5 (br m, 4H), 7.25 (d, 2H), 7.55 (d, 2H), 10.75 (s,1H)., 70261-82-4

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Zhang, Zaihui; Daynard, Timothy Scott; Sviridov, Serguei V.; Chafeev, Mikhail A.; Wang, Shisen; US2003/60453; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4,70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-((4-methylpiperazin-1-yl)methyl)phenylamine(4.7g) was added to a solution of Compound 2-5(5.28g) in n-butanol(130ml). The mixture was reacted at 90C for 4.0 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid in a yield of 85.7%. MS m/z(ESI): 412[M+H]+.

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.,70261-82-4

General procedure: A previously described method [19] was followed for the syntheses of 1-5, 7, 8, 10 and 20. Briefly, equimolar quantities of the amine and the acridine/quinoline were dissolved in ethanol, 2 drops of conc. HCl were added and the mixture refluxed for ca 24 h. On cooling, NaOH (1 M) or ammonia solution (25%) was added, followed by dichloromethane to extract the product. Alternatively, if the product precipitated out of solution on alkalinization, it was removed by filtration and purified by column chromatography.

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Article; Nguyen, Thuy; Sakasegawa, Yuji; Doh-Ura, Katsumi; Go, Mei-Lin; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 2917 – 2929;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

70261-82-4, To a solution of 4-(3-(4-cyanophenyl)imidazo[l,2-a]pyridin-6-yl)benzoic acid (70 mg, 0.206 mmol) in DMF (1.0 mL) were added HATU (117 mg, 0.309 mmol), TV-methyl morpholine (90 mu, 0.824 mmol) and 4-((4-methylpiperazin-l-yl)methyl)aniline (51 mg, 0.309 mmol). The reaction mixture was stirred at room temperature under inert atmosphere for 18 h, then it was diluted with water (15 mL) and extracted with EtOAc (3><30 mL). The combined organic layer was dried over Na2S04 and was concentrated under reduced pressure. The residue was purified by preparative HPLC (CI 8, eluent ACN, water, formic acid 0.1 %) to afford 4-(3-(4- cyanophenyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(4-((4-methylpiperazin- 1 - yl)methyl)phenyl)benzamide (40 mg, 37%, AUC HPLC 99%) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.78 (s, 1H), 8.05 (d, J= 8.4 Hz, 2H), 7.96-7.90 (m, 4H), 7.84 (s, 1H), 7.83 (d, J= 8.4 Hz, 2H), 7.80-7.76 (m, 2H), 7.68 (d, J= 8.8 Hz, 2H), 7.34 (d, J= 8.4 Hz, 2H), 3.56 (s, 2H), 2.70-2.40 (m, 8H), 2.36 (s, 3H); 13C NMR (100 MHz, CD3OD): delta 168.12, 147.47, 141.62, 139.17, 135.76, 134.82, 134.74, 134.53, 134.40, 131.08, 129.56, 129.44, 128.49, 128.30, 127.79, 126.61, 122.95, 122.18, 119.51, 118.48, 112.72, 63.14, 55.55, 53.15, 45.65; MS (ESI) m/z 527 [C33H30N6O + H] +. As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role. Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,70261-82-4

[0172] A suspension of intermediate 31 (50 mg, 0.18 mmol), 4-(4-methyl-piperazin-l- ylmethyl)-phenylamine (50 mg, 0.24 mmol), Pd2(dba)3 (10 mg, 0.011 mmol), Xantphos (13 mg, 0.022 mmol) and cesium carbonate (0.12 g, 0.37 mmol) in dioxane/DMF (3/1, 4 mL) was sealed in a microwave reaction tube and irradiated with microwave at 160 C for 15 min. After cooling to room temperature, the cap was removed and the resulting mixture filtered and the filtered solid washed with DCM. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (DCM to 10% MeOH/DCM)to afford the title compound (35 mg, 44%) as an off white solid.[0173] 1R NMR (500 MHz, DMSOd6): 5 2.11 (s, 3H), 2.15 (s, 3H), 2.20-2.45 (m, 8H), 3.35 (s, 2H), 3.75 (s, 3H), 7.07 (d, J= 8.5 Hz, 2H), 7.28 (d, J= 8.5 Hz, IH), 7.44 (dd, J= 8.7, 2.3 Hz, IH), 7.47 (d, J= 2.3 Hz, IH), 7.57 (d, J= 8.5 Hz, 2H), 7.91 (s, IH), 8.36 (s, IH), 8.98 (s, IH). MS (ES+): m/z 453 (M+H)+.

The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,70261-82-4

To a solution of 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)benzoic acid (70 mg, 0.206 mmol) in DMF (1.0 mL) were added HATU (117 mg, 0.309 mmol), N-methyl morpholine (90 muL, 0.824 mmol) and 4-((4-methylpiperazin-1-yl)methyl)aniline (51 mg, 0.309 mmol). The reaction mixture was stirred at room temperature under inert atmosphere for 18 h, then it was diluted with water (15 mL) and extracted with EtOAc (3*30 mL). The combined organic layer was dried over Na2SO4 and was concentrated under reduced pressure. The residue was purified by preparative HPLC (C18, eluent ACN, water, formic acid 0.1%) to afford 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide (40 mg, 37%, AUC HPLC 99%) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.78 (s, 1H), 8.05 (d, J=8.4 Hz, 2H), 7.96-7.90 (m, 4H), 7.84 (s, 1H), 7.83 (d, 0.1=8.4 Hz, 2H), 7.80-7.76 (m, 2H), 7.68 (d, J=8.8 Hz, 2H), 7.34 (d, J=8.4 Hz, 2H), 3.56 (s, 2H), 2.70-2.40 (m, 8H), 2.36 (s, 3H); 13C NMR (100 MHz, CD3OD): delta 168.12, 147.47, 141.62, 139.17, 135.76, 134.82, 134.74, 134.53, 134.40, 131.08, 129.56, 129.44, 128.49, 128.30, 127.79, 126.61, 122.95, 122.18, 119.51, 118.48, 112.72, 63.14, 55.55, 53.15, 45.65; MS (ESI) m/z 527 [C33H30N6O+H]+.

The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Agency for Science, Technology and Research; Nacro, Kassoum; Duraiswamy, Athisayamani Jeyaraj; Rao, Lohitha; US2014/371199; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-82-4, A suspension of 23 (0.10 g, 0.33 mmol), 4-(4-methyl-piperazin- 1-ylmethyl)- phenylamine (0.10 g, 0.49 mmol), Pd2(dba)3 (25 mg, 0.027 mmol), Xantphos (32 mg, 0.055 mmol) and cesium carbonate (0.22 g, 0.68 mmol) in dioxane (4 mL) was sealed in a microwave reaction tube and irradiated with microwave at 160 0C for 20 min. After cooling to room temperature, the resulting mixture was filtered and the filtered solid washed with DCM. The filtrate was concentrated and the residue purified by HPLC. The fractions were combined and poured into saturated NaHCO3 solution (25 mL). The combined aqueous layers were extracted with EtOAc (2 x 25 mL) and the combined organic layers washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated and the residue re- dissolved in minimum amount of EtOAc and hexanes added until solid precipitated. After filtration, the title compound was obtained as a yellow solid (10 g, 6%).[0204] 1H NMR (500 MHz, DMSO-d6): delta 2.18 (s, 3H), 2.25-2.45 (m, 8H), 2.46 (s, 3H), 3.41 (s, 2H), 7.00 (dd, J = 3.6, 1.7 Hz, IH), 7.21 (d, J = 8.5 Hz, 2H), 7.29 (dd, J= 8.4, 1.3 Hz, IH), 7.38 (dd, J = 3.6, 2.3 Hz, IH), 7.81 (s, IH), 7.87 (d, J= 8.5 Hz, 2H), 7.94 (d, J= 8.3 Hz, IH), 8.39 (s, IH), 9.27 (s, IH), 11.7 (s, IH) MS (ES+): m/z 469 (M+H)+

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Patent; TARGEGEN INC.; WO2009/49028; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics