Category: 76535-74-5

Li, Xu; Chen, Xiaolan; Yuan, Jinwei; Qu, Lingbo; Zhu, Haisheng; Bi, Wenzhu; Zhao, Yufen published the artcile< Synthesis and Characterization of Phosphoramide Piperazine Analogs of Paeonol>, COA of Formula: C9H19ClN2O2, the main research area is phosphoramide piperazine analog paeonol preparation.

Based on the phosphorylated reaction, an efficient general synthetic approach that provide facile, rapid and cheap access to a wide range of novel phosphoramide derivatives of paeonol has been developed. These analogs of paeonol are synthesized in high yields and elucidated by IR, HR MS, and NMR.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Phosphoramides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, COA of Formula: C9H19ClN2O2.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Chen, Xiaolan; Yuan, Jinwei; Qu, Lingbo; Qu, Zhibo; Xu, Shaohua; Wang, Fujun; Zhao, Yufen published the artcile< Synthesis and Spectroscopic Characterization of Some New Piperazine Phosphoramide Derivatives of 4-Hydroxycoumarin>, Recommanded Product: tert-Butyl piperazine-1-carboxylate hydrochloride, the main research area is piperazine phosphoramide hydroxycoumarin preparation.

A series of new piperazine phosphoramide derivatives of 4-hydroxycoumarin were synthesized through a facile phosphorylating reaction starting from 4-hydroxycoumarin and various phosphorylating agents. The title compounds were characterized by IR, NMR, electrospray ionization-mass spectrometry, and high-resolution mass spectrometry, and their spectroscopic data were further analyzed to feature the related spectroscopic characteristics of the compounds of this class.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Phosphorylation. 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, Recommanded Product: tert-Butyl piperazine-1-carboxylate hydrochloride.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Rudolf, Klaus; Eberlein, Wolfgang; Engel, Wolfhard; Pieper, Helmut; Entzeroth, Michael; Hallermayer, Gerhard; Doods, Henri published the artcile< Development of Human Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists. Potent and Selective Small Molecule CGRP Antagonists. 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)piperazine: The First CGRP Antagonist for Clinical Trials in Acute Migraine>, Computed Properties of 76535-74-5, the main research area is oxoquinazolinpiperazine derivative preparation CGRP receptor antagonist antimigraine migraine.

Although the triptans have greatly improved the acute treatment of migraine headache, there are yet many shortcomings. Therefore, new strategies for the treatment of migraine are needed which offer advantages over current therapy, e.g. triptans. Our novel approach was based on the hypothesis that the release of calcitonin gene-related peptide (CGRP) could play a causative role in migraine headache. Thus the authors initiated a program aimed at the design and synthesis of small mol. CGRP receptor antagonists. High throughput screening led to the identification of (R)-Tyr-(S)-Lys dipeptide-like compounds that showed weak but unequivocal binding to the human CGRP receptor. Lead optimization afforded highly potent CGRP antagonists, the prototype being compound (I) (BIBN4096). This compound exhibiting a favorable biol. profile was selected for initial clin. trials. A proof of concept study indicated that i.v. application of I was effective in the treatment of acute migraine headache. This finding strongly supports our initial working hypothesis that CGRP plays an important role in the pathophysiol. of migraine.

Journal of Medicinal Chemistry published new progress about Antimigraine agents. 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, Computed Properties of 76535-74-5.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Raja Sekhara Reddy, B.; Pratap Reddy Gajulapalli, V.; Madhu Rekha, Estharla; Siva Krishna, Vagolu; Sriram, Dharmarajan; Sudakar Babu, K.; Kim, Eunha published the artcile< Design, synthesis, and in vitro biological evaluation of dehydroaripiprazole derivatives as antituberculosis agents and molecular docking study>, HPLC of Formula: 76535-74-5, the main research area is dehydroaripiprazole derivative antituberculosis agent biol mol docking.

In this study, we describe the synthesis of novel piperazine-substituted 7-(4-chlorobutoxy) quinolin-2(1H) derivatives 5a-z, which were designed through specific structural modifications of aripiprazole. Furthermore, the synthesized derivatives were described as potent in vitro inhibitors of Mycobacterium tuberculosis (MTB) H37Rv strain growth. Among these compounds, 5c, 5 h, and 5r were found to be the most active ones with a MIC of 0.78 μg/mL. This activity is better compared to that of ethambutol (MIC = 1.56 μg/mL). These compounds failed to inhibit normal RAW 264.7 macrophages. Moreover, in vitro findings were supported by mol. docking studies with the known anti-TB target (InhA). The mol. docking studies on 5c, 5 h, and 5r hit compounds clearly validated hydrogen bonds interactions with the Enoyl-acp reductase (INHA). Therefore, these results indicate that this class of compounds may provide candidates for future development, and hopefully provide drug alternatives for tuberculosis treatment.

Results in Chemistry published new progress about Cytotoxicity. 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, HPLC of Formula: 76535-74-5.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cheng, Chuanjie; Sun, Jianwei; Xing, Lixin; Xu, Jimin; Wang, Xinyan; Hu, Yuefei published the artcile< Highly Chemoselective Pd-C Catalytic Hydrodechlorination Leading to the Highly Efficient N-Debenzylation of Benzylamines>, SDS of cas: 76535-74-5, the main research area is benzylamine debenzylation synergistic trichloroethane chemoselective hydrodechlorination palladium catalyst; amine hydrochloride preparation.

In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystalline amine hydrochlorides in practically quant. yields.

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent) (benzylic). 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, SDS of cas: 76535-74-5.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Du, Lifei; Wang, Xiaoyu; Cui, Guonan; Xu, Bailing published the artcile< Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors>, Recommanded Product: tert-Butyl piperazine-1-carboxylate hydrochloride, the main research area is thiazole based derivative human Pin1 inhibitors; PPIase; Pin1; Pin1 inhibitor; Thiazole derivatives.

Pin1 is a peptidyl prolyl cis-trans isomerase (PPIase) and inhibiting Pin1 is a potential way for discovering anti-tumor agents. With an aim to find potent Pin1 inhibitors with a novel scaffold, a series of thiazole derivatives with an alicyclic heterocycles on the 2-position were designed, synthesized and tested against human Pin1. Compound 9p bearing a 2-oxa-6-azaspiro [3,3] heptane moiety on the thiazole scaffold was identified as the most potent Pin1 inhibitor of this series with an IC50 value of 0.95μM. The structure-activity relationship (SAR) and mol. modeling study indicated that introducing an alicyclic ring with an H-bond acceptor would be a viable way to improve the binding affinity.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, Recommanded Product: tert-Butyl piperazine-1-carboxylate hydrochloride.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Verma, Sanjeev K.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik, M. P. published the artcile< CDI-mediated monoacylation of symmetrical diamines and selective acylation of primary amines of unsymmetrical diamines>, HPLC of Formula: 76535-74-5, the main research area is CDI monoacylation sym diamine acylation amine unsym.

A highly efficient and green protocol for monoacylation of sym. diamines and chemoselective acylation of primary amines of unsym. diamines was developed.

Green Chemistry published new progress about Acylation. 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, HPLC of Formula: 76535-74-5.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Verma, Sanjeev K.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik, M. P. published the artcile< CDI-mediated monoacylation of symmetrical diamines and selective acylation of primary amines of unsymmetrical diamines>, COA of Formula: C9H19ClN2O2, the main research area is CDI monoacylation sym diamine acylation amine unsym.

A highly efficient and green protocol for monoacylation of sym. diamines and chemoselective acylation of primary amines of unsym. diamines was developed.

Green Chemistry published new progress about Acylation. 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, COA of Formula: C9H19ClN2O2.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cheng, Chuanjie; Sun, Jianwei; Xing, Lixin; Xu, Jimin; Wang, Xinyan; Hu, Yuefei published the artcile< Highly Chemoselective Pd-C Catalytic Hydrodechlorination Leading to the Highly Efficient N-Debenzylation of Benzylamines>, Product Details of C9H19ClN2O2, the main research area is benzylamine debenzylation synergistic trichloroethane chemoselective hydrodechlorination palladium catalyst; amine hydrochloride preparation.

In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystalline amine hydrochlorides in practically quant. yields.

Journal of Organic Chemistrypublished new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent) (benzylic). 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, Product Details of C9H19ClN2O2.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics