Category: 780705-64-8

Site-Selective C-H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis was written by McManus, Joshua B.;Onuska, Nicholas P. R.;Jeffreys, Matthew S.;Goodwin, Nicole C.;Nicewicz, David A.. And the article was included in Organic Letters in 2020.Formula: C13H20N4O2 This article mentions the following:

Substituted piperazines such as I were prepared by C-H alkylation of piperazines such as tert-Bu 4-benzoyl-1-piperazinecarboxylate with electron-deficient alkenes such as PhCH:C(CN)₂ under blue LED irradiation in the presence of a diarylacridinium salt as a photoredox catalyst. The regioselectivity of the photoredox alkylation reactions was correlated to the difference between the calculated electron populations at the nitrogen atoms of the neutral compounds and the calculated electron populations at the nitrogen atoms of the radical cations. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate (cas: 780705-64-8Formula: C13H20N4O2).

tert-Butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate (cas: 780705-64-8) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Formula: C13H20N4O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Photocatalyzed Dehydrogenation of Aliphatic N-Heterocycles Releasing Dihydrogen was written by Ritu;Das, Saikat;Tian, Ya-Ming;Karl, Tobias;Jain, Nidhi;Konig, Burkhard. And the article was included in ACS Catalysis in 2022.Application of 780705-64-8 This article mentions the following:

Author’s report the iridium-nickel dual photocatalytic acceptorless and redox neutral dehydrogenation of aliphatic heterocycles yielding cyclic alkenes without overoxidn. at room temperature Excitation of the iridium photocatalyst initiates the formation of a nickel hydride intermediate that yields alkenes and H₂ via β-hydride elimination. The reaction proceeds regioselectively and the scope was demonstrated by the synthesis of 12 biol. relevant mols. and drugs. In addition, com. and easily available N-heterocyclic alkane starting materials were converted into functionalized alkenes of high synthetic and com. value using the method. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate (cas: 780705-64-8Application of 780705-64-8).

tert-Butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate (cas: 780705-64-8) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 780705-64-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics