Category: 791846-40-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.791846-40-7,tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

STEP B: 2-[4-(4-Bromo-2-cvano-phenyl)-piperazin-1-yl)-N.N-diethyl-2-phenyl-acetamide. A solution of 4-(4-Bromo-2-cyano-phenyl)-piperazine-1 -carboxylic acid tert- butyl ester (151.6mg) prepared as in STEP A above was dissolved in CH2CI2 (3 ml_) and the resulting mixture treated with TFA (1 ml_). The resulting mixture was stirred for 6h, then the solvent was removed to yield a residue. To the residue was added 2-bromo-N,N-diethyl-2-phenyl-acetamide (0.14g), Na2CO3 (0.2Og) and DMF (3 ml_). The resulting mixture was stirred for 16h, then diluted with water (50 ml_) and extracted with diethyl ether. The resulting mixture was dried over MgSO4, the solvent was removed and the resulting residue purified on SiO2 (hexanes/ EtOAc O to 50%) to yield the title compound., 791846-40-7

The synthetic route of 791846-40-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Janssen Pharmaceutica N.V.; WO2009/79593; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.791846-40-7,tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

STEP B: 2-[4-(4-Bromo-2-cvano-phenyl)-piperazin-1-yl)-N.N-diethyl-2-phenyl-acetamide. A solution of 4-(4-Bromo-2-cyano-phenyl)-piperazine-1 -carboxylic acid tert- butyl ester (151.6mg) prepared as in STEP A above was dissolved in CH2CI2 (3 ml_) and the resulting mixture treated with TFA (1 ml_). The resulting mixture was stirred for 6h, then the solvent was removed to yield a residue. To the residue was added 2-bromo-N,N-diethyl-2-phenyl-acetamide (0.14g), Na2CO3 (0.2Og) and DMF (3 ml_). The resulting mixture was stirred for 16h, then diluted with water (50 ml_) and extracted with diethyl ether. The resulting mixture was dried over MgSO4, the solvent was removed and the resulting residue purified on SiO2 (hexanes/ EtOAc O to 50%) to yield the title compound., 791846-40-7

The synthetic route of 791846-40-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Janssen Pharmaceutica N.V.; WO2009/79593; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

791846-40-7, tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,791846-40-7

To a solution of 1-16 (2.5 g, 6.83 mmcl) in DMSO (6 mL) were added aqueous 30% H202 (0.15 ml, 8.88 mmcl) and K2003 at 0CC, and the reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reactionmixture was poured into ice cold water (100 ml) and extracted with diethyl ether (100 mL x 3) . The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product so obtained was purified by silica gel column chromatography (60-120 mesh) using 30% EtOAc in hexanesas eluent to give the desired product 1-17 (1.3 g, 50%) as a white solid; LOMS: m/z 384.0 [M+1]

As the paragraph descriping shows that 791846-40-7 is playing an increasingly important role.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KOUL, Summon; KURHADE, Suresh; NAIK, Keshav; SALUNKHE, Videsh; KULKARNI, Rakesh; PARDESHI, Vishwajeet; BHUNIYA, Debnath; KULKARNI, Bheemashankar; MOOKHTIAR, Kasim Abbaas; (274 pag.)WO2017/38909; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics