Category: 841-77-0

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a document, author is Liu, Lixin, introduce the new discover, Recommanded Product: 1-Benzhydrylpiperazine.

Pharmaceutical salts/cocrystals of enoxacin with dicarboxylic acids: Enhancing in vitro antibacterial activity of enoxacin by improving the solubility and permeability

Base on improving the solubility and permeability of enoxacin (EX) to enhance the antibacterial activity in vitro, three new pharmaceutical salts/cocrystals of EX with oxalic acid (EX center dot 0.5(C2H2O4)center dot 2(H2O)), malonic acid ((HEX)center dot C3H3O4) and fumaric acid ((HEX)center dot C4H3O4) have been designed, synthesized and characterized. Comprehensive analysis structure and Hirshfeld surface reveal that the hydrogen bonds/CAHBs formed by the N atom in the piperazine ring from EX molecule with the carboxylic acid group in the coformer could form a stable crystal structure. It is universally acknowledged that improving the solubility of the EX (BCS class II) to make it a BCS class I drug would obtain a Bioequivalence of immunity to the drug trial. The solubilities of three pharmaceutical salts/cocrystals of EX with dicarboxylic acids are consistent with expectation that they are dramatically improved in pure water than pure enoxacin, and the solubility order of three pharmaceutical salts/ cocrystals of EX is consistent with coformers solubility. The permeabilities of three pharmaceutical salts/cocrystals of EX are improved compared with the pure enoxacin, and the variation tendency is consistent with the solubilities of three pharmaceutical salts/cocrystals of EX. In addition, the antibacterial activities in vitro of three pharmaceutical salts/cocrystals of EX are improved compared with the corresponding parent compound (EX), which change the order is consistent with the solubility and permeability. Simultaneously, the hygroscopic stabilities of three pharmaceutical salts/cocrystals are surpassing pure EX, and the hygroscopic stability of molecular cocrystal EX-OXA is better than ionic cocrystal EX-MLO and EX-FUM. This implies that preparation of the pharmaceutical salts/cocrystals of EX with oxalic acid, malonic acid and fumaric acid could not only enhance the antibacterial activity of EX, which base on improving the solubility and permeability of EX, but also improve the hygroscopic stability of EX.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 841-77-0 is helpful to your research. Recommanded Product: 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Sarmad, Shokat, once mentioned the application of 841-77-0, Product Details of 841-77-0, Name is 1-Benzhydrylpiperazine, molecular formula is C17H20N2, molecular weight is 252.3541, MDL number is MFCD00038379, category is piperazines. Now introduce a scientific discovery about this category.

Amine functionalized deep eutectic solvent for CO2 capture: Measurements and modeling

Deep eutectic solvents (DESs) have gained a great interest among researchers owing to their inherent advantages to become an adaptable alternative to ionic liquids (ILs) and common amine solutions for CO2 capture. In the present study, we prepared five new three-component DESs by functionalization of choline chloride-ethanolamine (1:7, mol:mol) DES using different types of amines: diethanolamine (amine type 2), methyldiethanolamine (amine type 3), piperazine (amine type 2) as well as 1-(2-aminoethyl)piperazine (amine type 1 and 2). All of the prepared DESs are liquid at room temperature and their melting points were in the range of 265-276 K. The solubility of CO2 in the studied DESs was measured at pressures up to 2 MPa and 298.15 K. The obtained experimental data were analyzed by the use of generic Redlich-Kwong equation of state (RK-EOS) model and Henry’s law constant have been calculated from the obtained experimental data through the EOS correlation. All the studied DESs show chemical absorption of CO2 which can be approved based on the excess enthalpy and Gibbs energy functions. FT-IR spectroscopy and C-13 NMR verified the formation of carbamate in the CO2 absorption process which revealed the chemisorption of CO2 in the studied DESs. The ideal association model has been utilized to describe the excess thermodynamic functions and two different types of the chemical association have been detected AB 2 and AB, (A refer to DESs and B to CO). 2 Based on the obtained solubility data, the amines that enhanced the absorption capacity of choline chloride-ethanolamine (1:7) follow the trend as follows: piperazine > aminoethylpiperazine > methyldiethanolamine > diethanolamine. Therefore, piperazine can be considered as an absorption enhancer. The viscosity of DESs before and after CO2 absorption as well as the thermal behavior of the DESs were also investigated. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 841-77-0, Name is 1-Benzhydrylpiperazine, formurla is C17H20N2. In a document, author is Faroughi Niya, Homayoun, introducing its new discovery. HPLC of Formula: C17H20N2.

Fe3O4@THAM-piperazine: a novel and highly reusable nanocatalyst for one-pot synthesis of 1,8-dioxo-octahydro-xanthenes and benzopyrans

A novel magnetically heterogeneous nanocatalyst has been successfully synthesized via the immobilization of piperazine on tris (hydroxymethyl) aminomethane-coated Fe3O4 magnetic nanoparticles. The described catalyst was fully characterized by various techniques such as FT-IR, EDS, DTG/TGA, XRD, TEM, SEM, and VSM analyses. The catalytic efficacy of Fe3O4@THAM-piperazine has investigated for one-pot synthesis of tetrahydrobenzo[b]pyran and 1,8-dioxo-octahydro-xanthene derivatives. Notable features of this user-friendly catalytic system include high yields, high catalytic activity, simple operation, non-toxicity, and easy work-up. Also, the new nanocatalyst could be easily recovered and reused for six times without significant loss of activity. [GRAPHICS]

If you are hungry for even more, make sure to check my other article about 841-77-0, HPLC of Formula: C17H20N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 841-77-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a article, author is Rezaei, Mohammad Taher, introduce new discover of the category.

Synthesis of a tertiary amine by direct reductive amination of a carbonyl compound to form a scorpionate ligand; formation of Mn (II), Zn (II) and Cd (II) complexes, DFT calculations and, molecular docking studies

A hexadentate, asymmetric tripodal scorpionate type ligand, [[N1-Pyridin-2-ylmethyl-N1-[2-(4-pyridine2-ylmethyl-piperazine-1-yl)-ethyl]-ethane-1,2-diamine]] (L) has been prepared. To form this ligand, the direct reductive amination of a carbonyl compound by NaBH4 was used for the synthesis of tertiary amine. The complexes [MnL])ClO4((2), [CdL])ClO4((2), [ZnL])ClO4((2) have also been prepared. The synthesized compounds were characterized by elemental analyses, FT-IR, ESI-MS and, NMR spectroscopy. An X-ray crystal structure of [MnL] (ClO4)(2), shows that the coordination environment around the manganese is a distorted trigonal prism. The nature of metal-ligand bonding in the complexes was investigated by Natural Bond Orbital analysis, Energy Decomposition Analysis and Energy Decomposition Analysis using Natural Orbitals for Chemical Valence variation. Molecular docking has been used for the biological evaluation of the anticancer and antioxidant activities of the synthesized compounds. The docking results indicated that the Cd, Mn, and Zn-complexes had the highest binding affinity (MolDock Score) for the binding sites of cytochrome P450, myeloperoxidase, and cytochrome P450, respectively. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 841-77-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 841-77-0 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is an experimental science, Name: 1-Benzhydrylpiperazine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 841-77-0, Name is 1-Benzhydrylpiperazine, molecular formula is C17H20N2, belongs to piperazines compound. In a document, author is Yuan, Xueling.

Enhanced research of absorption by mass transfer promoters

Activators such as piperazine (PZ) are widely used to increase the CO2 absorption rate of aqueous methyl-diethanolamine (MDEA) solutions by accelerating reaction. However, a big difference (1 to 2 orders of magnitude) in the enhancement of absorption rate with the addition of PZ was obtained in different studies. In this work, it was proved that mass transfer is the rate-limiting step in the above process and in most cases enhancing mass transfer is quite essential. Some low-polar solvents were screened as mass transfer promoters (MTPs) to enhance mass transfer by inducing interfacial turbulence, which markedly improved the CO2 absorption performance of MDEA solutions. The individual addition of PZ and MTPs to the MDEA solution, which correspond to the reaction enhancement and the mass transfer enhancement, increased the absorption rate by 131% and 33%-319%, respectively. The co-effects of enhancing both reaction and mass transfer (in the presence of activators and MTPs) can lead to 2 to 10-fold increase in the absorption rate. Furthermore, MTPs could increase the CO2 cyclic loading and desorption rate by 27% and 100%, respectively, indicating that the MDEA/MTPs had significant advantages for reducing the energy consumption in CO2 capture applications.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 841-77-0. Name: 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a document, author is Lai, Weikang, introduce the new discover, Name: 1-Benzhydrylpiperazine.

BiVO4 prepared by the sol-gel doped on graphite felt cathode for ciprofloxacin degradation and mechanism in solar-photo-electro-Fenton

In this research, bismuth vanadate-doped graphite felt (GF-BiVO4) was successfully prepared by sol-gel method, in which BiVO4 owned superior electro-Fenton (EF) and solar-photo-electro-Fenton (SPEF) performance. Combined with the analysis by X-ray diffractometer (XRD), field emission transmission electron microscopy (FE-TEM), nitrogen adsorption-desorption isotherms and cyclic voltammetry (CV), the changes of electrodes were reflected in structure and physicochemical properties. The doping of monoclinic BiVO4 endued GF with a higher surface area and more electro-active sites and better electrode activity in comparison to Raw-GF. Then, the GFs were used as cathodes to detect center dot OH concentration with coumarin (COU) as probe molecule and to evaluate photoelectric performance with ciprofloxacin (CIP) in photocatalysis, EF and SPEF processes. The resultYs demonstrated that the concentration of center dot OH followed an order of SPEF > EF > photocatalysis, which was consistent with the removal rate of CIP (99.8%, 99.4% and 21.2%, respectively) on GF-BiVO4 at 5 min. Further, five degradation pathways of CIP in SPEF system were proposed including the attack on piperazine ring, oxidation on cyclopropyl group, decarboxylation and hydroxyl radical addition, oxidation on benzene group and defluorination. The study provides insights into the enhancement of EF and SPEF performance and the degradation pathway of CIP in SPEF.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 841-77-0 is helpful to your research. Name: 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, in an article , author is Nawaz, Hamid, once mentioned of 841-77-0, Formula: C17H20N2.

Structural chemistry and anticancer activity of new heteroleptic palladium(II) carbodithioates

Four new potent anticancer palladium(II) complexes containing PdClPS2 coordination sphere have been synthesized and characterized by different analytical techniques. Here, P is the donor atom from organophosphine (triphenylphosphine (1 and 3) and tris(p-chlorophenyl)phosphine (2 and 4)) and S 2 chelate is from carbodithioate (N,N’-dibenzyl-1-carbodithioate (1 and 2) and 4-(2hydroxyethyl)piperazine-1-carbodithioate (3 and 4)). All complexes exhibited distorted square planar geometry around Pd center owing to the chelate restriction of carbodithioate. The complexes are more potent anticancer (1-4) and antioxidant (3) agents than the standard drugs ((anticancer activity against HepG2: IC50 (mu M) = 23.39 (1) < 77.27 (3) < 82.62 (2) < 86.65 (4) 110 (doxorubicin) and (antioxidant activity against DPPH 65.6 (%) (3) and total antioxidant capacity expressed as equivalent of ascorbic acid (3) 51.4 mu g/mg, respectively)). Interestingly, the complexes demonstrated low lethal effects as determined by brine shrimp assay. The lethality sequence is opposite to that observed in anticancer (LD50 (ppm): 102.87 (1) 65.54 (3) > 62.50 (2) > 39.82 (4)) indicating high selectivity of 1 and 3 towards cancer cells. Anticancer activities were found to depend on the molecular stability and axial protection offered by organophosphine of the complexes. (c) 2020 Elsevier B.V. All rights reserved.

Interested yet? Read on for other articles about 841-77-0, you can contact me at any time and look forward to more communication. Formula: C17H20N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 841-77-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a article, author is Corre, Michelle F., introduce new discover of the category.

Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands – Functional characterization and modeling studies on H-3 and H(4 )receptors

Histamine acts through four different receptors (H1R-H4R), the H3R and H4R being the most explored in the last years as drug targets. The H3R is a potential target to treat narcolepsy, Parkinson’s disease, epilepsy, schizophrenia and several other CNS-related conditions, while H4R blockade leads to anti-inflammatory and immunomodulatory effects. Our group has been exploring the dihydrobenzofuranyl-piperazines (LINS01 series) as human H3R/H4R ligands as potential drug candidates. In the present study, a set of 12 compounds were synthesized from adequate (dihydro)benzofuran synthons through simple reactions with corresponding piperazines, giving moderate to high yields. Four compounds (1b, 1f, 1g and 1h) showed high hH(3)R affinity (pK(i) > 7), compound 1h being the most potent (pK(i) 8.4), and compound if showed the best efficiency (pKi 8.2, LE 0.53, LLE 5.85). BRET-based assays monitoring G alpha(i) activity indicated that the compounds are potent antagonists. Only one compound (2c, pK(i) 7.1) presented high affinity for hH(4)R. In contrast to what was observed for hH(3)R, it showed partial agonist activity. Docking experiments indicated that bulky substituents occupy a hydrophobic pocket in hH(3)R, while the N-allyl group forms favorable interactions with hydrophobic residues in the TM2, 3 and 7, increasing the selectivity towards hH(3)R. Additionally, the importance of the indole NH in the interaction with Glu5.46 from hH(4)R was confirmed by the modeling results, explaining the affinity and agonistic activity of compound 2c. The data reported in this work represent important findings for the rational design of future compounds for hH(3)R and hH(4)R.

Electric Literature of 841-77-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 841-77-0.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 841-77-0, Name is 1-Benzhydrylpiperazine, molecular formula is C17H20N2, belongs to piperazines compound, is a common compound. In a patnet, author is Zhu, Meilin, once mentioned the new application about 841-77-0, Safety of 1-Benzhydrylpiperazine.

Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures, and Biological Activities

Epipolythiodioxopiperazines (ETPs) are a class of biologically active fungal secondary metabolites characterized by a bridged polysulfide piperazine ring. Regularly, the sulfide functionality is attached in the alpha-positions of the dioxopiperazine scaffold. However, ETPs possessing irregular sulfur bridges have rarely been explored. This review summarizes that 83 compounds of this subtype have been isolated and characterized since the discovery of gliovirin in 1982. Herein, particular emphasis is given to the isolation, chemistry, and biological activity of this subtype. For a better understanding, a relevant summary focusing on the source microorganisms and their taxonomy is provided and will help elucidate the fascinating chemistry and biology of these unusual ETPs.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 841-77-0. The above is the message from the blog manager. Safety of 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 841-77-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a article, author is Pan, Yingtong, introduce new discover of the category.

Synergistic flame retardant effect of piperazine salt and ammonium polyphosphate as intumescent flame retardant system for polypropylene

Amino trimethylene phosphonic acid piperazine (ATPIP)salt, as a novel charring agent, is prepared via a simple ionic reaction in distilled water using amino trimethylene phosphate (ATMP) and piperazine as raw materials. The synergistic flame retardant effect of ATPIP and ammonium polyphosphate (APP) as an intumescent flame retardant (IFR) is investigated by various characterization and testing methods. The results show that the polypropylene (PP)/modified APP with piperazine (MAPP)/ATPIP ternary blend passes UL-94 V-0 rating and achieve a limiting oxygen index (LOI) of 30% at a loading level of 25 wt% IFR (MAPP:ATPIP = 3:1). Meanwhile, the total smoke production (TSP) value of IFR-PP samples is 3.3 m(2), which decreases by 93.2% compared with that of pure PP, exhibiting excellent smoke suppression performance. Besides, the analysis of gaseous pyrolysis products and char residue indicates that the IFR-PP samples show a synergistic flame-retardant mechanism including the gas phase and the condensed phase.

Synthetic Route of 841-77-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 841-77-0 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics