Category: 84477-85-0

84477-85-0, Benzyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17 4-[4-Benzyloxycarbonyl-2-methyl-1-piperazinyl]-2-trifluoromethylbenzonitrile A 1.01 g portion of benzyl 3-methylpiperazine-1-carboxylate synthesised in Reference Example 10, 814 mg of 4-fluoro-2-trifluoromethylbenzonitrile and 2.38 g of potassium carbonate were added to 20 ml of DMF and stirred at 100C for 20 hours. This was mixed with water, extracted with ethyl acetate and dried, and then the solvent was evaporated. The resulting residue was purified by a silica gel column chromatography to obtain 440 mg of the title compound from ethyl acetate-hexane (3:1, v/v) elude.

84477-85-0, The synthetic route of 84477-85-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1122242; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-85-0, Benzyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17 4-[4-Benzyloxycarbonyl-2-methyl-1-piperazinyl]-2-trifluoromethylbenzonitrile A 1.01 g portion of benzyl 3-methylpiperazine-1-carboxylate synthesised in Reference Example 10, 814 mg of 4-fluoro-2-trifluoromethylbenzonitrile and 2.38 g of potassium carbonate were added to 20 ml of DMF and stirred at 100C for 20 hours. This was mixed with water, extracted with ethyl acetate and dried, and then the solvent was evaporated. The resulting residue was purified by a silica gel column chromatography to obtain 440 mg of the title compound from ethyl acetate-hexane (3:1, v/v) elude.

84477-85-0, The synthetic route of 84477-85-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1122242; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-85-0, Benzyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17 4-[4-Benzyloxycarbonyl-2-methyl-1-piperazinyl]-2-trifluoromethylbenzonitrile A 1.01 g portion of benzyl 3-methylpiperazine-1-carboxylate synthesised in Reference Example 10, 814 mg of 4-fluoro-2-trifluoromethylbenzonitrile and 2.38 g of potassium carbonate were added to 20 ml of DMF and stirred at 100C for 20 hours. This was mixed with water, extracted with ethyl acetate and dried, and then the solvent was evaporated. The resulting residue was purified by a silica gel column chromatography to obtain 440 mg of the title compound from ethyl acetate-hexane (3:1, v/v) elude.

84477-85-0, The synthetic route of 84477-85-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1122242; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-85-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84477-85-0,Benzyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

3-Methyl-l-piperazinecarboxylic acid, phenylmethyl ester (380 mg), the product from example 13 part (a) (400 mg) and MgSO4 were stirred in THF (30 ml) for 20 h. Sodium triacetoxy borohydride (510 mg) was added and stirred for 2 h. The mixture was quenched with water, extracted with EtOAc, washed with water and brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by chromatography on silica with 20%EtOAc/isohexane as eluent to yield the sub-title compound (500 mg).MS: APCI (+ve): 490 (M+l) 1H NMR (DMSO-d6) 6 7.34 (m, 6H), 7.23 (dd, IH), 6.88 (d, IH), 5.08 (dd, 2H), 4.68 (s, 2H),3.80 (m, IH), 3.66 (m, IH), 3.34 (m, 2H), 3.21 – 3.08 (m, IH), 3.05 – 2.81 (m, IH), 2.65 (m,IH), 2.46 (m, IH), 2.14 (m, IH), 1.41 (s, 9H), 1.03 (d, 3H)

84477-85-0 Benzyl 3-methylpiperazine-1-carboxylate 10421542, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/56752; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-85-0, Benzyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 49 4-Benzyloxycarbonyl-1-(4-methyl-5-isoquinolinesulfonyl)-2-methylpiperazine To a solution of 1-benzyloxycarbonyl-3-methylpiperazine (5.09 g) in chloroform (150 ml), a solution of triethylamine (3.0 ml) and 4-methyl-5-isoquinolinesulfonyl chloride (6.05 g) in chloroform (50 ml) was gradually added dropwise. After completion of the dropwise addition, the resultant mixture was continuously stirred at 60C for 20 hours.The reaction mixture was washed first with water (100 ml x 2) and then with a saturate aqueous solution of sodium chloride (100 ml), and was then dried over anhydrous magnesium sulfate. The solvent was then distilled off under reduced pressure. The resulting residue was purified by chromatography on a silica gel column (chloroform), whereby 3.95 g of the target compound were obtained. 1H-NMR (270 MHz, CDCl3) delta: 9.15(1H,s), 8.54(1H,s), 8.37(1H,dd,J=7.92,1.32Hz), 8.17(1H,dd,J=7.92,1.32Hz), 7.61(1H,t,J=7.59Hz), 7.36(5H,m), 5.17(2H,dd,J=14.85,12.21Hz), 4.05-4.18(3H,m), 3.33-3.55(3H,m), 3.04(3H,s), 1.34(3H,d,J=6.60Hz)., 84477-85-0

As the paragraph descriping shows that 84477-85-0 is playing an increasingly important role.

Reference£º
Patent; Hidaka, Hiroyoshi; EP1074545; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics