Category: 86393-32-0

On April 1, 1989, Lopez Molina, Isidro; Palomo Coll, Alberto; Domingo Coto, Antonio published a patent.HPLC of Formula: 86393-32-0 The title of the patent was Preparation of ciprofloxacin hydrochloride monohydrate from higher hydrates. And the patent contained the following:

The antibacterial title compound(I.HCl.H2O) is prepared by treating higher hydrates I.HCl.xH2O (x > 1) with an aliphatic or aromatic alc., an N,N-dialkyl aliphatic amide, or a mixture, at moderate temperatures for ≤3 h. Thus, 4.51 g I.HCl.2.5H2O (preparation given) was refluxed in 45 mL iso-PrOH for 30 min, followed by hot filtration, washing and drying in air at 50° to give I.HCl.H2O in 99% yield. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).HPLC of Formula: 86393-32-0

The Article related to ciprofloxacin hydrochloride monohydrate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.HPLC of Formula: 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cao, Ling-feng; Zhang, Yong-tang; Zhang, Jing-zheng published an article in 2011, the title of the article was Improved process of the piperazine condensation for preparation of ciprofloxacin hydrochloride.Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate And the article contains the following content:

Ciprofloxacin hydrochloride I complying with CP, EP and USP standard was prepared via substitution of cyclopropanecarboxylic acid with anhydrous piperazine. A novel reaction system was developed effectively to reduce the amount of two main byproducts and to increase product yield and quality. Based on the reaction system, other factors were investigated such as the equivalent of piperazine, the reaction temperature and reaction time to determine the optimal parameters of piperazine: the n-pentanol:2-Me pyrrolidone (v:v = 1:1) mixed solvent, 4 mol/L of anhydrous piperazine, 125°C∼130°C and reaction of 8 h, the total yield can reach 81.9%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to ciprofloxacin hydrochloride preparation cyclopropanecarboxylic acid piperazine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 30, 2005, Liu, Yong; Wang, Jingkang; Yin, Qiuxiang published an article.Electric Literature of 86393-32-0 The title of the article was Determination of the space group for ciprofloxacin hydrochloride monohydrate crystals. And the article contained the following:

Ciprofloxacin hydrochloride monohydrate (CPFX) crystals were obtained exptl. The deaquation, melting, decomposing apex temperatures and water content of ciprofloxacin hydrochloride monohydrate crystals were measured by DSC and TG techniques resp. The data of X-ray powder diffraction (XRPD) of these crystals were collected exptl. The indexing results by the software Cerius2 were obtained. The results showed that the crystal of ciprofloxacin hydrochloride monohydrate belonged to monoclinic, and the unit cell parameters a, b, c and β were 12.93×10-10 m, 19.56×10-10 m, 7.07×10-10 m, and 91.10° resp. Based on the indexing results and the extinction principle, the space group for ciprofloxacin hydrochloride monohydrate crystals produced in crystallization experiment was P21/c. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0

The Article related to ciprofloxacin hydrochloride monohydrate x ray powder diffraction space group, unit cell parameter, Crystallography and Liquid Crystals: Crystallographic Methods and Apparatus For Structure Determination and other aspects.Electric Literature of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 31, 2005, Rizk, N. M. H.; El-Kosasy, A. M. published an article.SDS of cas: 86393-32-0 The title of the article was Novel ciprofloxacin ion membrane sensors based on β-cyclodextrin. And the article contained the following:

Ciprofloxacin (CF) is sensitively detected in pharmaceuticals and human serum by potentiometric method. The proposed method based on the use of β-cyclodextrin (βCD) as ionophore, o-nitrophenyl octyl ether as plasticizer and potassium tetraphenyl-fluoromethylborate as a cationic additive, in polyvinyl chloride (PVC) matrix for the fabrication and construction of ciprofloxacin sensors. The conventional and microsized coated wire types are prepared, characterized compared and applied. The proposed sensors exhibit linear response in the range of 1×10-1-1×10-4 M ciprofloxacin with cationic slopes of 30.2±0.5 and 29.3±0.6 mV decade-1 at 25° over the pH range 4-6 for conventional and microsized coated wire, resp. Ciprofloxacin electrodes show reasonable selectivity towards some related compounds, amino acids, common organic and inorganic cations. The investigated procedures are successfully applied to the determination of ciprofloxacin in bulk powder, pharmaceutical products and human serum. Results with mean accuracy 99.8±0.6 % and 99.6±0.7 % for the nominal concentrations were obtained for conventional and microsized coated wire, resp., which compare well with data obtained using spectrophotometric (UV-Vis) method. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).SDS of cas: 86393-32-0

The Article related to ciprofloxacin sensor beta cyclodextrin ionophore potassium tetraphenyl fluoromethylborate, cationic additive pharmaceutical preparation nitrophenyl octyl ether plasticizer and other aspects.SDS of cas: 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2021, Nielsen, Soeren Saxmose; Bicout, Dominique Joseph; Calistri, Paolo; Canali, Elisabetta; Drewe, Julian Ashley; Garin-Bastuji, Bruno; Gonzales Rojas, Jose Luis; Gortazar Schmidt, Christian; Herskin, Mette; Michel, Virginie; Miranda Chueca, Miguel Angel; Padalino, Barbara; Pasquali, Paolo; Roberts, Helen Clare; Spoolder, Hans; Stahl, Karl; Velarde, Antonio; Viltrop, Arvo; Winckler, Christoph; Dewulf, Jeroen; Guardabassi, Luca; Hilbert, Friederike; Mader, Rodolphe; Baldinelli, Francesca; Alvarez, Julio published an article.Application of 86393-32-0 The title of the article was Assessment of animal diseases caused by bacteria resistant to antimicrobials: sheep and goats. And the article contained the following:

In this opinion, the antimicrobial-resistant bacteria responsible for transmissible diseases that constitute a threat to the health of sheep and goats have been assessed. The assessment has been performed following a methodol. based on information collected by an extensive literature review and expert judgement. Details of the methodol. used for this assessment are explained in a sep. opinion. A global state of play on antimicrobial resistance in clin. isolates of Staphylococcus aureus, Escherichia coli (non-VTEC), Pseudomonas aeruginosa, Dichelobacter nodosus, Moraxella ovis, Mannheimia haemolytica, Pasteurella multocida, Mycoplasma ovipneumoniae, Mycoplasma agalactiae, Trueperella pyogenes, Streptococcus uberis, Bibersteinia trehalosi, Campylobacter fetus, Mycoplasma mycoides subsp. capri, Mycoplasma capricolum subsp. capricolum, Fusobacterium necrophorum is provided. Among those bacteria, EFSA identified E. coli with > 66% certainty as being the most relevant antimicrobial-resistant bacteria in sheep and goat in the EU based on the available evidence. The animal health impact of these most relevant bacteria, as well as their eligibility for being listed and categorized within the animal health law framework will be assessed in sep. scientific opinions. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application of 86393-32-0

The Article related to animal diseases caused bacteria resistant antimicrobial sheep goat, animal health law, antimicrobial resistance, extensive literature review, goats, sheep, small ruminants and other aspects.Application of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 30, 2005, Liu, Yong; Wang, Jingkang; Yin, Qiuxiang published an article.Electric Literature of 86393-32-0 The title of the article was Determination of the space group for ciprofloxacin hydrochloride monohydrate crystals. And the article contained the following:

Ciprofloxacin hydrochloride monohydrate (CPFX) crystals were obtained exptl. The deaquation, melting, decomposing apex temperatures and water content of ciprofloxacin hydrochloride monohydrate crystals were measured by DSC and TG techniques resp. The data of X-ray powder diffraction (XRPD) of these crystals were collected exptl. The indexing results by the software Cerius2 were obtained. The results showed that the crystal of ciprofloxacin hydrochloride monohydrate belonged to monoclinic, and the unit cell parameters a, b, c and β were 12.93×10-10 m, 19.56×10-10 m, 7.07×10-10 m, and 91.10° resp. Based on the indexing results and the extinction principle, the space group for ciprofloxacin hydrochloride monohydrate crystals produced in crystallization experiment was P21/c. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0

The Article related to ciprofloxacin hydrochloride monohydrate x ray powder diffraction space group, unit cell parameter, Crystallography and Liquid Crystals: Crystallographic Methods and Apparatus For Structure Determination and other aspects.Electric Literature of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 31, 2005, Rizk, N. M. H.; El-Kosasy, A. M. published an article.SDS of cas: 86393-32-0 The title of the article was Novel ciprofloxacin ion membrane sensors based on β-cyclodextrin. And the article contained the following:

Ciprofloxacin (CF) is sensitively detected in pharmaceuticals and human serum by potentiometric method. The proposed method based on the use of β-cyclodextrin (βCD) as ionophore, o-nitrophenyl octyl ether as plasticizer and potassium tetraphenyl-fluoromethylborate as a cationic additive, in polyvinyl chloride (PVC) matrix for the fabrication and construction of ciprofloxacin sensors. The conventional and microsized coated wire types are prepared, characterized compared and applied. The proposed sensors exhibit linear response in the range of 1×10-1-1×10-4 M ciprofloxacin with cationic slopes of 30.2±0.5 and 29.3±0.6 mV decade-1 at 25° over the pH range 4-6 for conventional and microsized coated wire, resp. Ciprofloxacin electrodes show reasonable selectivity towards some related compounds, amino acids, common organic and inorganic cations. The investigated procedures are successfully applied to the determination of ciprofloxacin in bulk powder, pharmaceutical products and human serum. Results with mean accuracy 99.8±0.6 % and 99.6±0.7 % for the nominal concentrations were obtained for conventional and microsized coated wire, resp., which compare well with data obtained using spectrophotometric (UV-Vis) method. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).SDS of cas: 86393-32-0

The Article related to ciprofloxacin sensor beta cyclodextrin ionophore potassium tetraphenyl fluoromethylborate, cationic additive pharmaceutical preparation nitrophenyl octyl ether plasticizer and other aspects.SDS of cas: 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2021, Nielsen, Soeren Saxmose; Bicout, Dominique Joseph; Calistri, Paolo; Canali, Elisabetta; Drewe, Julian Ashley; Garin-Bastuji, Bruno; Gonzales Rojas, Jose Luis; Gortazar Schmidt, Christian; Herskin, Mette; Michel, Virginie; Miranda Chueca, Miguel Angel; Padalino, Barbara; Pasquali, Paolo; Roberts, Helen Clare; Spoolder, Hans; Stahl, Karl; Velarde, Antonio; Viltrop, Arvo; Winckler, Christoph; Dewulf, Jeroen; Guardabassi, Luca; Hilbert, Friederike; Mader, Rodolphe; Baldinelli, Francesca; Alvarez, Julio published an article.Application of 86393-32-0 The title of the article was Assessment of animal diseases caused by bacteria resistant to antimicrobials: sheep and goats. And the article contained the following:

In this opinion, the antimicrobial-resistant bacteria responsible for transmissible diseases that constitute a threat to the health of sheep and goats have been assessed. The assessment has been performed following a methodol. based on information collected by an extensive literature review and expert judgement. Details of the methodol. used for this assessment are explained in a sep. opinion. A global state of play on antimicrobial resistance in clin. isolates of Staphylococcus aureus, Escherichia coli (non-VTEC), Pseudomonas aeruginosa, Dichelobacter nodosus, Moraxella ovis, Mannheimia haemolytica, Pasteurella multocida, Mycoplasma ovipneumoniae, Mycoplasma agalactiae, Trueperella pyogenes, Streptococcus uberis, Bibersteinia trehalosi, Campylobacter fetus, Mycoplasma mycoides subsp. capri, Mycoplasma capricolum subsp. capricolum, Fusobacterium necrophorum is provided. Among those bacteria, EFSA identified E. coli with > 66% certainty as being the most relevant antimicrobial-resistant bacteria in sheep and goat in the EU based on the available evidence. The animal health impact of these most relevant bacteria, as well as their eligibility for being listed and categorized within the animal health law framework will be assessed in sep. scientific opinions. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application of 86393-32-0

The Article related to animal diseases caused bacteria resistant antimicrobial sheep goat, animal health law, antimicrobial resistance, extensive literature review, goats, sheep, small ruminants and other aspects.Application of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On February 6, 2003, Stankovic, Slobodan; Mitov, Slobodan; Stanojevic, Caslav published a patent.Synthetic Route of 86393-32-0 The title of the patent was A process for synthesis of antibiotic fluoroquinolonic acid derivatives. And the patent contained the following:

A simple and convenient procedure for obtaining antibiotics of fluoroquinolonic derivatives of general formula (I; where R, R2 = H, C1-4 alkyl; R1 = C1-4 alkyl, cycloalkyl such as cyclopropyl), and/or salts and hydrates thereof, in particular ciprofloxacin and norfloxacin, and is developed by amination of piperazine or piperazine derivatives (II; R = same as above) with the 6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivative of general formula (III; R1 , R2 = same as above) in an inert solvent of pharmacopoeic purity, at risen temperature The process is characterized in lower reaction temperature, atm. pressure reaction, tech. simplicity of the procedure of purification by conversion and isolation in the form of pharmaceutically acceptable salts, increased yields, reducing cost on the procedure for industrial use, as well as pharmacopoeic purity of the product, enabled their use as the antibiotics in human and veterinary medicine. Thus, a mixture of 49.25 g 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 72.25 g piperazine, and 250 cm3 of DMSO was heated for 1.5 to 2 h at 140°, cooled to 70°, treated with 985 cm3 distilled water, and then treated with 62.5 cm3 concentrated HCl with stirring and cooling. Formed suspension was filtered and the precipitate was rinsed with distilled water, suspended in water, dissolved by addition of 2 mol/dm3 HCl, treated with active charcoal, heated with stirring at 50°, and filtered. To the filtrate was added 2 mol/dm3 NaOH with stirring and cooling and the formed suspension was filtered. The precipitate was rinsed with distilled water, suspended in water with stirring, treated with 60 cm3 2 mol/dm3 HCl, heated for 30 min at 75-80°, and added to 1,750 cm3 absolute ethanol. The mixture was cooled to 0-5° and filtered, and the precipitate was rinsed three times with 30 cm3 absolute ethanol each time, and dried in vacuum drier at 80° to give 49.46 g ciprofloxacin hydrochloride monohydrate (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazinoquinoline-3-carboxylic acid hydrochloride monohydrate) as white crystals having m.p. 308-310° (decomposition) in 73% yield. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Synthetic Route of 86393-32-0

The Article related to fluoroquinolonic acid preparation antibiotic, ciprofloxacin hydrochloride monohydrate preparation antibiotic, fluoropiperazinodihydrooxoquinolinecarboxylic acid preparation antibiotic, norfloxacin preparation antibiotic and other aspects.Synthetic Route of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On August 10, 2022, Wang, Linqiong; Li, Yi; Zhao, Zhe; Zhu, Mengjie; Hu, Tong published an article.Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the article was Tidal flat aquaculture pollution governs sedimentary antibiotic resistance gene profiles but not bacterial community based on metagenomic data. And the article contained the following:

Coastal tidal flats are intersection zones between terrestrial and marine environments and are considered repositories of pollutants from anthropogenic activities (e.g., fishery and aquaculture). Specifically, the prevalence of antibiotics and antibiotic resistance genes (ARGs) in coastal aquaculture environments pose critical threats to estuarine ecosystems. However, the contribution of aquaculture to the occurrence and abundance of ARGs and community assemblies has not been fully explored in tidal flat zones. Thus, we investigated ARGs profiles, ARG-carrying host bacteria, and their associate microbial community in the Dongtai and Sheyang tidal flat aquaculture regions of Jiangsu, China using metagenomic assembly methods. The antibiotic concentrations in the sediment samples ranged from nd to 35.50 ng/g dw, and the antibiotic pollution in the Dongtai tidal flat was more severe than in the Sheyang tidal flats. Metagenomic assembly indicated that a total of 247 ARG subtypes associated with ARG 33 types were characterized across all samples and their abundance in the Dongtai region exceeded that in the Sheyang region. Meanwhile, 21 bacteria in the tidal flat aquaculture were identified as ARG-carrying pathogens, including Escherichia coli, Vibrio fluvialis, and Staphylococcus aureus. Using neutral and null modeling anal. to determine the community ecol. processes, the results revealed bacterial and ARG communities were generally dominated by stochastic and deterministic processes, resp. The above results suggested that aquaculture pollution was contributed to shape ARG profiles in tidal flats. The observed deterministic processes affecting the ARG community in tidal flat aquaculture also provides an effective foundation to control the risks of environmental antibiotic resistance through reducing aquaculture antibiotic usage. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to antibiotic resistance gene bacterial community metagenomic data aquaculture pollution, arg host bacteria, antibiotic resistance genes, ecological processes, metagenomic assembly, tidal flat aquaculture and other aspects.Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics