Category: 87179-40-6

Kilbourn, Michael R. published the artcileSynthesis of fluorine-18-labeled flunarizine, Application of (E)-1-Cinnamylpiperazine, the publication is Applied Radiation and Isotopes (1991), 42(2), 109-11, database is CAplus and MEDLINE.

Flunarizine, a calcium channel antagonist of the piperazine class, has been labeled with the positron-emitter ¹⁸F. 4-[¹⁸F]fluoro-4′-fluorobenzhydryl chloride was prepared in 3 steps from no-carrier-added [¹⁸F]fluoride ion, and used in the alkylation of N-cinnamylpiperazine to give [¹⁸F]flunarizine in 13% radiochem. yield (from [¹⁸F]fluoride).

Applied Radiation and Isotopes published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Application of (E)-1-Cinnamylpiperazine.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Sanz Sharley, Daniel D. published the artcileAcetic acid as a catalyst for the N-acylation of amines using esters as the acyl source, Related Products of piperazines, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(12), 2020-2023, database is CAplus and MEDLINE.

Authors report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either Et acetate or Bu acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120°. The methodol. can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20°.

Chemical Communications (Cambridge, United Kingdom) published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Related Products of piperazines.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Bogdanov, Andrei V. published the artcileNew N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity, Related Products of piperazines, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2016), 52(1), 25-30, database is CAplus.

A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-[(piperazinyl)methyl]isatins, which were further converted to isoindigo derivatives The antimicrobial activity of the obtained heterocycles was evaluated.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Related Products of piperazines.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Castellote, Isabel published the artcilePyrrolodiazines. 6. Palladium-Catalyzed Arylation, Heteroarylation, and Amination of 3,4-Dihydropyrrolo[1,2-a]pyrazines, Formula: C13H18N2, the publication is Journal of Organic Chemistry (2004), 69(25), 8668-8675, database is CAplus and MEDLINE.

The palladium-catalyzed Suzuki cross-coupling reaction of arylboronic acids and 6-bromo- and 6,8-dibromo-3,4-dihydropyrrolo[1,2-a]pyrazines afforded 6-substituted and 6,8-disubstituted 3,4-dihydropyrrolo[1,2-a]pyrazines in good yields. Stille and Negishi coupling reactions have been used to prepare 6-heteroaryl-substituted derivatives in moderate yields by employing heteroaryl halides and 6-metalated 3,4-dihydropyrrolo[1,2-a]pyrazines as reaction partners. A variety of cyclic secondary amines have also been incorporated at position C-6 of 6-bromo-1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine in the presence of the palladium catalyst Pd₂(dba)₃ in conjunction with BINAP as ligand. This amination reaction is one of the few reported examples of such a palladium-catalyzed transformation on a pyrrole ring, although the reaction could not be extended to less nucleophilic amines.

Journal of Organic Chemistry published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Formula: C13H18N2.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Onida, Killian published the artcileDirect Synthesis of Thiocarbamoyl Fluorides and Trifluoromethylamines Through Fluorinative Desulfurization, Application In Synthesis of 87179-40-6, the publication is European Journal of Organic Chemistry (2019), 2019(35), 6106-6109, database is CAplus.

Herein, a straightforward synthesis of thiocarbamoyl fluorides is reported starting from amines and carbon disulfide. The key to success is the fluorinative desulfurization of carbon disulfide with (diethylamino)sulfur trifluoride (DAST). The title compounds were obtained in moderate to very good isolated yields. Furthermore, we demonstrated also that thiocarbamoyl fluoride can be converted into their trifluoromethylamine analogs through simple treatment with silver fluoride.

European Journal of Organic Chemistry published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Application In Synthesis of 87179-40-6.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Bangalore, Pavan K. published the artcileUsnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents, Related Products of piperazines, the publication is Journal of Natural Products (2020), 83(1), 26-35, database is CAplus and MEDLINE.

(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range of biol. properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and insecticidal activities. Interested by these pharmacol. activities and to tap into its potential, we herein present the synthesis and biol. evaluation of new usnic acid enaminone-conjugated 1,2,3-triazoles as antimycobacterial agents. (+)-Usnic acid was condensed with propargyl amine to give usnic acid enaminone with a terminal ethynyl moiety. It was further reacted with various azides under copper catalysis to give triazoles in good yields. Among the synthesized compounds, saccharin derivative I proved to be the most active analog, inhibiting Mycobacterium tuberculosis (Mtb) at an MIC value of 2.5μM. Analogs with 3,4-difluorophenacyl and 2-acylnaphthalene units inhibited Mtb at MIC values of 5.4 and 5.3μM, resp. Among the tested Gram-pos. and Gram-neg. bacteria, the new derivatives were active on Bacillus subtilis, with compounds with [3-(trifluoromethyl)phenacyl] and (N-acylmorpholinyl) showing inhibitory concentrations of 41 and 90.7μM, resp., while they were inactive on the other tested bacterial strains. Overall, the study presented here is useful for converting natural (+)-usnic acid into antitubercular and antibacterial agents via incorporation of enaminone and 1,2,3-triazole functionalities.

Journal of Natural Products published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Related Products of piperazines.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Sari, Sait published the artcileSynthesis and characterization of unsaturated diacyl and alkyl-acyl piperazine derivatives, COA of Formula: C13H18N2, the publication is Turkish Journal of Chemistry (2019), 43(6), 1656-1710, database is CAplus.

The aim of this study is to obtain new unsaturated piperazine compounds by the reaction of piperazine derivatives with acyl chlorides. Methacryloyl piperazine was synthesized from the reaction of methacrylic anhydride with piperazine. Few acyl chlorides were prepared by the reaction of thionyl chloride with carboxylic acids which were obtained as a result of the reaction of malonic acid and suitable aldehydes. The remaining acyl chlorides were synthesized by the reaction of thionyl chloride with carboxylic acids which were obtained from hydrolyzation of esters. Sym. diacyl piperazine compounds were obtained from the reaction of Methacryloyl piperazine with corresponding acyl chlorides. In addition, from the reaction of Methacryloyl piperazine and corresponding acyl chlorides, nonsym. diacyl piperazine compounds were synthesized in medium to good yields (63%-84%). Also, alkyl-acyl piperazine compounds were obtained from the reaction of allyl piperazine and cinnamyl piperazine with corresponding acyl chlorides.

Turkish Journal of Chemistry published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, COA of Formula: C13H18N2.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Gawlik, Maciej published the artcileSimulation of phase I metabolism reactions of selected calcium channel blockers by human liver microsomes and photochemical methods with the use of Q-TOF LC/MS, Computed Properties of 87179-40-6, the publication is Journal of Pharmaceutical and Biomedical Analysis (2019), 112776, database is CAplus and MEDLINE.

The in vitro phase I metabolism of perhexiline and flunarizine, two calcium channel blockers was investigated during this study with the use of human liver microsomes (HLM) method compared with TiO₂, WO₃ and ZnO catalyzed photochem. reaction. In order to determine the structures of metabolites an quadrupole time-of-flight mass spectrometry combined with liquid chromatog. (Q-TOF LC/MS) system was used. The obtained high resolution mass spectra enabled to identify thirteen products of metabolism of selected drugs including three not yet described metabolites of perhexiline and two new metabolites of flunarizine. The vast majority of metabolites were confirmed also with the participation of photocatalytic approach of the drug metabolism simulation. The comparison of all metabolic profiles made with the use of computational methods drew attention particularly to TiO₂ and WO₃ catalyzed photochem. reaction as similar to HLM incubation. Addnl., in silico toxicity assessment of the detected transformation products of the analyzed substances was also evaluated.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Computed Properties of 87179-40-6.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Corsano, Stefano published the artcileSynthesis and pharmacological evaluation of some analogs of the calcium-antagonist cinnarizine, Recommanded Product: (E)-1-Cinnamylpiperazine, the publication is Archiv der Pharmazie (Weinheim, Germany) (1988), 321(3), 171-4, database is CAplus and MEDLINE.

Title compounds, e.g. I, II, and Ph₂CHNHCH₂CH₂OC₆H₃(OMe)₂-2,6, were prepared Thus, 1-benzhydrylpiperazine was treated with o-MeOC₆H₄OCH₂CH₂Br to give I. The new compounds had lower Ca antagonist activity than cinnarizine.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Recommanded Product: (E)-1-Cinnamylpiperazine.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Xie, Chao published the artcileNatural Product Glycine Betaine as an Efficient Catalyst for Transformation of CO₂ with Amines to Synthesize N-Substituted Compounds, Safety of (E)-1-Cinnamylpiperazine, the publication is ACS Sustainable Chemistry & Engineering (2017), 5(8), 7086-7092, database is CAplus.

Transformation of carbon dioxide (CO₂) into value-added chems. is of great importance, and use of natural products as a catalyst is very interesting. Herein, we used the naturally occurring glycine betaine as an efficient and renewable catalyst for the formation of a C-N bond between CO₂ and amines using PhSiH₃ as the reductant. The effects of different factors on the reaction were studied. It was demonstrated that the catalyst was very active for the reactions, and a broad range of amine substrates could be converted with satisfactory yields. Moreover, the selectivity to different N-substituted compounds could be controlled by the molar ratio of reactants (i.e., CO₂, amines, and PhSiH₃) and the reaction temperature In the catalytic cycle, the carbon oxidation state of CO₂ could be reduced to +2, 0, and -2, resp., and thus, the corresponding formamides, aminals, and methylamines were produced via successive two-electron reduction steps.

ACS Sustainable Chemistry & Engineering published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C2H5BF3K, Safety of (E)-1-Cinnamylpiperazine.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics