879896-50-1, 2-(4-Methylpiperazin-1-ylmethyl)benzylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
879896-50-1, General procedure: To a microwave vial containing a solution of Boc-L-glutamic acid tert-butyl ester (0.165 mmol, 1.0 equiv) and HATU (0.165 mmol, 1.0 equiv) in DMF (1.65 mL) was added the amine followed by DIPEA (57.5 muL, 2.0 equiv). The vial was sealed and heated under microwave irradiation for 30 min at 120 C. Upon completion, the reaction was partitioned between water and CH2Cl2, extracted 3¡Á with CH2Cl2, dried over anhydrous Na2SO4, and concentrated under vacuum. Compounds were purified via reverse phase chromatography (5-95% acetonitrile/water) to afford the N-Boc-glutamylanilide-tert-butyl esters. The compounds were transferred to vials followed by the addition of 2.0 mL of 4.0 M HCl in dioxane. The reaction stirred at 40 C for 4 h. The reactions were concentrated under vacuum to afford the title compounds which were used without further purification.
879896-50-1 2-(4-Methylpiperazin-1-ylmethyl)benzylamine 16228064, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Schulte, Michael L.; Dawson, Eric S.; Saleh, Sam A.; Cuthbertson, Madison L.; Manning, H. Charles; Bioorganic and Medicinal Chemistry Letters; vol. 25; 1; (2015); p. 113 – 116;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics