Category: 883554-88-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883554-88-9,4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester,as a common compound, the synthetic route is as follows.,883554-88-9

To a solution of tert-butyl4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) in DCM (2 mL) was addeda HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 30 min andconcentrated to give the title compound as a white solid (0.16 g, 100) . 1H NMR (600 MHz, CD3OD): delta ppm 3.71-3.73 (m, 4H) , 3.25-3.27 (m, 4H) and MS-ESI: m/z 130.10[M+H-HCl] + .

883554-88-9 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester 17750351, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883554-88-9,4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester,as a common compound, the synthetic route is as follows.,883554-88-9

To a solution of tert-butyl4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) in DCM (2 mL) was addeda HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 30 min andconcentrated to give the title compound as a white solid (0.16 g, 100) . 1H NMR (600 MHz, CD3OD): delta ppm 3.71-3.73 (m, 4H) , 3.25-3.27 (m, 4H) and MS-ESI: m/z 130.10[M+H-HCl] + .

883554-88-9 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester 17750351, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

883554-88-9, 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

883554-88-9, The compound 4-carbamoyl-piperazine-1-carboxylate (0.16g, 0.7mmol) was dissolved in dichloromethane(2mL) was added HCl The ethyl acetate solution (4M, 2mL), stirred at rt for 30min, the solvent was removed togive 0.16g of white solid: piperazin-1-carboxamide hydrochloride Salt, yield: 100%.

As the paragraph descriping shows that 883554-88-9 is playing an increasingly important role.

Reference：
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

883554-88-9, 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The white solid from step A in ethanol (50 mL) was cooled to 0 C., and a pre-mixed solution of NaOCl (10-13% active chlorine, 43.4 mL) and 15% NaOH (78.0 mL) was added dropwise via an addition funnel. The ice bath was removed and the resulting mixture was stirred at room temperature for 1 h. 1N HCl was added to the resulting mixture until the pH of the solution was about pH 1, and the resulting mixture was stirred at room temperature for an additional 15 min. The pH of the solution was made basic with saturated aqueous potassium carbonate, and the resulting solution concentrated in vacuo to half the volume, then extracted three times with EtOAc, the combined organics were dried with Na2SO4, and concentrated in vacuo to yield the title compound, which was used in the next step without further purification. MS 202 (M+1)+, 883554-88-9

883554-88-9 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester 17750351, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; MACIELAG, Mark J.; Tennakoon, Manomi; US2009/275594; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883554-88-9,4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester,as a common compound, the synthetic route is as follows.

883554-88-9, Intermediate 28: Piperazine-1-carboxylic acid amide hydrochloride; [] 4-Piperazine-1-carboxylic acid tert-butyl ester (1.0g, 5.4mmol), acetic acid (3ml) and water (5ml) were mixed together. Potassium cyanate (2.25g, 27.7mmol) was added portionwise as a solution in water (5ml) and stirred for 4 hours, during which time a solid precipitated. The solid was filtered, re-dissolved in DCM (20ml), dried over MgSO4, filtered, the filter cake washed with DCM (5vol) and concentrated in vacuo to give a white solid (0.38g). The white solid (0.38g) was dissolved in methanol (3.8ml) and 1,4-dioxane (0.7ml), 4M HCl in 1,4-dioxane (2.5ml, 10mmol) was added to the reaction and stirred overnight. The reaction was concentrated in vacuo to give the title compound (0.28g, 31% over 2 steps) as a white solid.1H NMR (400MHz, DMSO-d6) delta9.18 (br s, 2H), 3.91 (br s, 2H), 3.45 (br s, 4H), 2.93 (br s, 4H).

As the paragraph descriping shows that 883554-88-9 is playing an increasingly important role.

Reference£º
Patent; Warner-Lambert Company LLC; EP1593679; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883554-88-9,4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester,as a common compound, the synthetic route is as follows.,883554-88-9

To a solution of tert-butyl4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) in DCM (2 mL) was addeda HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 30 min andconcentrated to give the title compound as a white solid (0.16 g, 100) . 1H NMR (600 MHz, CD3OD): delta ppm 3.71-3.73 (m, 4H) , 3.25-3.27 (m, 4H) and MS-ESI: m/z 130.10[M+H-HCl] + .

883554-88-9 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester 17750351, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

883554-88-9,883554-88-9, 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 108b. Piperazine-1-carboxamide trifluoroacetate saltA solution of the product of Example 108a (1.5 g, 6.5 mmol) in trifluoroacetic acid (5 ml_) and dichloromethane (15 ml_) was stirred at rt for 3h. The mixture was concentrated. The residue was triturated with ethyl acetate (5 ml_ x 2) and diethyl ether (5 mL x 2), dried under vaccum to give the title compound as colorless syrup (1.5 g, yield: 95%). 1H NMR (400 MHz, DMSO-de) delta 9.11 (s, 2H)1 7.04 – 5.66 (br, s, 2H), 3.57 – 3.45 (m, 4H), 3.06 (s, 4H).

The synthetic route of 883554-88-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd; WO2010/147653; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883554-88-9,4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester,as a common compound, the synthetic route is as follows.

To a solution of tert-butyl4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) in DCM (2 mL) was addeda HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 30 min andconcentrated to give the title compound as a white solid (0.16 g, 100) . 1H NMR (600 MHz, CD3OD): delta ppm 3.71-3.73 (m, 4H) , 3.25-3.27 (m, 4H) and MS-ESI: m/z 130.10[M+H-HCl] + ., 883554-88-9

The synthetic route of 883554-88-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

883554-88-9, 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

883554-88-9, The compound 4-carbamoyl-piperazine-1-carboxylate (0.16g, 0.7mmol) was dissolved in dichloromethane(2mL) was added HCl The ethyl acetate solution (4M, 2mL), stirred at rt for 30min, the solvent was removed togive 0.16g of white solid: piperazin-1-carboxamide hydrochloride Salt, yield: 100%.

As the paragraph descriping shows that 883554-88-9 is playing an increasingly important role.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883554-88-9,4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester,as a common compound, the synthetic route is as follows.

To a solution of tert-butyl4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) in DCM (2 mL) was addeda HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 30 min andconcentrated to give the title compound as a white solid (0.16 g, 100) . 1H NMR (600 MHz, CD3OD): delta ppm 3.71-3.73 (m, 4H) , 3.25-3.27 (m, 4H) and MS-ESI: m/z 130.10[M+H-HCl] + ., 883554-88-9

The synthetic route of 883554-88-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics