Category: 923565-99-5

Hamblett, Christopher L. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2007 | CAS: 923565-99-5

(R)-1-Cbz-2-methylpiperazine (cas: 923565-99-5) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Recommanded Product: 923565-99-5

The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors was written by Hamblett, Christopher L.;Methot, Joey L.;Mampreian, Dawn M.;Sloman, David L.;Stanton, Matthew G.;Kral, Astrid M.;Fleming, Judith C.;Cruz, Jonathan C.;Chenard, Melissa;Ozerova, Nicole;Hitz, Anna M.;Wang, Hongmei;Deshmukh, Sujal V.;Nazef, Naim;Harsch, Andreas;Hughes, Bethany;Dahlberg, William K.;Szewczak, Alex A.;Middleton, Richard E.;Mosley, Ralph T.;Secrist, J. Paul;Miller, Thomas A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 923565-99-5 This article mentions the following:

This communication highlights the development of a nicotinamide series of histone deacetylase inhibitors (e.g. I) within the benzamide structural class. Extensive exploration around the nicotinamide core led to the discovery of a class I selective HDAC inhibitor that possesses excellent intrinsic and cell-based potency, acceptable ancillary pharmacol., favorable pharmacokinetics, sustained pharmacodynamics in vitro, and achieves in vivo efficacy in an HCT116 xenograft model. In the experiment, the researchers used many compounds, for example, (R)-1-Cbz-2-methylpiperazine (cas: 923565-99-5Recommanded Product: 923565-99-5).

(R)-1-Cbz-2-methylpiperazine (cas: 923565-99-5) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Recommanded Product: 923565-99-5

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

New learning discoveries about (R)-1-Cbz-2-methylpiperazine

923565-99-5 (R)-1-Cbz-2-methylpiperazine 40424346, apiperazines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.923565-99-5,(R)-1-Cbz-2-methylpiperazine,as a common compound, the synthetic route is as follows.,923565-99-5

To a room temperature solution of (iotaR)-benzyl 2-methylpiperazine-l-carboxylate (1.7 g, 7.2 mmol, 1.0 equiv) and and 3-amino-2-fluorobenzaldehyde (1.0 g, 7.2 mmol, 1.0 equiv) in THF (10 mL) was added NaHB(OAc)3 (3.84 g, 18.1 mmol, 2.5 equiv) as a solid in one portion. After stirring at room temperature for 1.5 h, the reaction was complete, as determined by LCMS. The remaining reducing reagent was quenched by the careful addition of aq. satd. NaHCtheta3, and the mixture was diluted with EtOAc. The layers were separated and the organic layer was washed with aq. satd. NaHCtheta3 and brine, dried over sodium sulfate and concentrated in vacuo to provide (/?)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine- 1-carboxylate (2.8 g, >100% mass recovery). The material was used without further purification. LCMS m/z (APCI) = 358.5 (M+H).

923565-99-5 (R)-1-Cbz-2-methylpiperazine 40424346, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; CYTOKINETICS, INC.; WO2007/70683; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Simple exploration of 923565-99-5

The synthetic route of 923565-99-5 has been constantly updated, and we look forward to future research findings.

923565-99-5,923565-99-5, (R)-1-Cbz-2-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Description 27: Phenylmethyl (2R)-2-methyl-4-({4-[2-(methyloxy)-2-oxoethyl]phenyl}methyl)-1- piperazinecarboxylate (D27). A mixture of D16 (243mg, 1mmol), diisopropylethylamine (174ul, 1mmol) 1,1- dimethylethyl (2R)-2-methyl-1-piperazinecarboxylate (234mg, 1mmol) in DMF was stirred at room temperature for 1 h then allowed to stand overnight. The solvent was removed in vacuo, then the residue was diluted with water (20ml) and extracted with EtOAc (2x20ml). The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give the title compound as a yellow oil (383mg). deltaH (CDCI3, 250MHz) 7.21-7.40 (9H, m), 5.13 (2H, AB) 4.29 (1 H1 m), 3.91 (1 H, m), 3.70 (3H, s), 3.62 (2H, s), 3.43 (2H, m), 3.20 (1 H1 m), 2.78 (1H1 m), 2.62 (1 H1 m), 2.05-2.18 (2H1 m), 1.29 (3H1 d).

The synthetic route of 923565-99-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/12479; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics