Category: 934-98-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

To a solution of 5-chloro-3-(4-methoxy-phenyl)-3 H-[ 1 ,2, 3]triazolo[4, 5-dJ- pyrimidine (200 mg, 0.76 mmol) in THF (4 ml) is added triethylamine (107 p1,0.76 mmol). The reaction mixture is stirred for 1 hour at room temperature. The reaction mixture is partitioned between dichioromethane and water. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica gel column with dichloromethane/methanol toafford [3-(4-methoxy-phenyl)-3H-[1 ,2 ,3]triazolo[4,5-djpyrimid in-5-yl]-[2-(4- methyl-piperazin-1 -yl)-ethy]-amine as off-white powder; HPLC/MS 1.47 mm (A), [M+H] 369; 1H NMR (500 MHz, DMSO-d6) O [ppm] 9.22 (s, IH), 8.03 (d, J = 8.2 Hz, 2H), 7.92 (m, 1H), 7.17 (d, J = 9.0 Hz, 2H), 3.85 (s, 3H), 3.49?3.41 (m, 2H), 3.30 (m, 2H), 2.53 (m, 2H), 2.45 (m, 2H), 2.30 (m, 4H), 2.14 (s, 3H).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; MERCK PATENT GMBH; DORSCH, Dieter; HOELZEMANN, Guenter; CALDERINI, Michel; WEGENER, Ansgar; POESCHKE, Oliver; WO2014/135244; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

General procedure: The mixture of 6-bromobenzo[d]thiazol-2-amine (2.0 g, 8.73 mmol), carbonyldimidazole (4.24 g, 26.2 mmol) and dried DMF (20 ml) was stirred at room temperature for 8 h, added cyclopropanamine (0.76 g, 13.2 mmol), then stirred at room temperature for another 8 h. The volatile was removed under reduced pressure. Water (30 ml) was added to the residue. The resulting suspension was stirred. After standing, the solid was collected by filtration, dried to produce 8a (1.77 g, 65percent) as white solid. 4.1.1.7 1-(6-Bromobenzo[d]thiazol-2-yl)-3-(2-(4-methylpiperazin-1-yl)ethyl)urea (8g) White solid; Yield 64percent; mp: 97-99 °C; 1H NMR (CDCl3) delta 7.85 (s, 1H, Ar-H), 7.52 (d, J = 8.6 Hz, 1H, Ar-H), 7.47 (d, J = 8.6 Hz, 1H, Ar-H), 3.49 (s, 2H, CH2), 2.78-2.41 (m, 10H, CH2 CH2*5), 2.35 (s, 3H, CH3). MS (ESI, m/z): Calcd for [M+H]+ C15H21BrN5OS: 398, 400, found 398, 400.

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Xie, Xiao-Xiao; Li, Huan; Wang, Juan; Mao, Shuai; Xin, Min-Hang; Lu, She-Min; Mei, Qi-Bing; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6477 – 6485;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 2-chloro-N-(3-chlorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)quinazolin-4-amine (Example 1, 39.9 mg, 0.1 mmol) and 2-(4-methylpiperazin-1-yl)ethanamine (143 mg, 1.0mmol) was added EtOH (1 ml). The tube was sealed and heated at 90 00 for 16 h. After cooling to rt, the mixture was filtered through a filter, and submitted for purification to give N4-(3- chlorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)-N2-(2-(4-methylpiperazin- 1 -yl)ethyl)quinazoline-2,4- diamine, 2TFA (28.6 mg, 0.039 mmol, 39.0 percent yield). 1H NMR (400 MHz, DMSO-d6) O 12.81 (5,1H), 10.07 (5, 1H), 9.62 (d, J= 141.1 Hz, 1H), 8.23 (d, J= 1.8 Hz, 1H), 7.82 (dd, J= 8.4, 1.7 Hz,1 H), 7.52 (d, J = 8.5 Hz, 1 H), 7.46 (t, J = 1.9 Hz, 1 H), 7.42 ? 7.27 (m, 3H), 4.83 (d, J = 5.7 Hz,2H), 4.43?2.67 (m, 15H), 2.42 (5, 3H), 2.25 (d, J= 1.4 Hz, 3H). (including 1 salt NH); MS(M+H)= 506., 934-98-5

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; STROVEL, Jeffrey William; YOSHIOKA, Makoto; MALONEY, David J.; YANG, Shyh Ming; JADHAV, Ajit; URBAN, Daniel Jason; (334 pag.)WO2017/91661; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

A mixture of 97 (0.30 g, 0.88 mmol), EDC.HCl (0.25 g, 1.32 mmol), HOBt (0.14 g, 1.06 mmol), NMM (0.23 ml, 2.11 mmol) and DMF (2.5 ml) was stirred for a while, to which was then added 2-(4-methylpiperazin-1-yl)ethylamine (0.16 ml, 1.06 mmol) at room temperature and stirred overnight. The residue was purified by flash column over silica gel (dichloromethane: methanol = 9:1, Rf = 0.19) to afford 49 (0.08 g, 19.47 percent) as a red solid. 1H-NMR (300 MHz, DMSO-d6): delta 2.13 (s, 3H), 2.36-2.42 (br, 12H), 4.91 (d, J= 6.3 Hz, 2H), 7.29 (d, J= 7.8 Hz, 2H), 7.67-7.77 (m, 4H), 7.88 (d, J= 6.9 Hz, 2H), 7.98 (br, 1H), 8.25 (br, 1H)., 934-98-5

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-ping; PAN, Shiow-lin; (44 pag.)WO2017/20030; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

General procedure: To a solution of 6-amino-4-anilinoquinazoline or 4-(1-phenylethyl)quinazoline-4,6-diamine (0.23 mmol) in acetonitrile(5 mL), CDI (0.11 g, 0.69 mmol) was added. The reaction mixture was stirred at room temperature for 8 h when lots of solidproduced. To this suspension, the solution of 2-(4-methylpiperazin-1-yl)ethylamine in 5 mL of acetonitrile was added. Then, the mixture was stirred at room temperature for 2 h, refluxed for another 2 h, cooled to room temperature and concentrated under reduced pressure. The residue was added water (20 mL) and the mixture was extracted with dichloromethane (20 mL 3). The organic layer was combined, washed with brine (20 mL), dried(Na2SO4), concentrated under reduced pressure and purified bychromatography on silica gel (dichloromethane/methanol = 15:1,v/v) to give compounds 4a or 4b as yellow powder. 4.1.60. 1-(2-(4-Methylpiperazin-1-yl)ethyl)-3-(4-((3-(trifluoromethyl)phenyl)amino)quinazolin-6-yl)urea (4a)Yield 45.5percent. Mp: 169.8?170.5 C. 1H NMR (DMSO-d6): d 9.96 (s,1H, N-H), 9.03 (s, 1H, N-H), 8.54 (s, 1H, N-H), 8.46 (d, 1H, Ar-H,J = 2.0 Hz), 8.29 (s, 1H, Ar-H), 8.21 (d, 1H, Ar-H, J = 8.0 Hz), 7.83(dd, 1H, Ar-H, J1 = 2.0 Hz, J2 = 8.8 Hz), 7.74 (d, 1H, Ar-H,J = 8.8 Hz), 7.62 (t, 1H, Ar-H, J = 8.0 Hz), 7.44 (d, 1H, Ar-H,J = 7.6 Hz), 6.35 (t, 1H, Ar-H, J = 5.2 Hz), 3.20?3.29 (m, 4H,2 CH2), 2.41?2.49 (m, 8H, 4 N-CH2), 2.27 (s, 3H, N-CH3). 13CNMR (DMSO-d6): d 157.4, 155.6, 152.5, 145.9, 141.0, 139.2, 130.0,129.5, 128.8, 126.7, 124.7 (d, JC?F = 261 Hz), 126.0, 119.8, 118.4,116.2, 109.3, 57.6, 54.7 (2 CH2), 52.4 (2 CH2), 45.5, 36.9. ESIHRMSm/z: calcd for C23H27F3N7O [M+H]+: 474.2229; found:474.2224.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Zuo, Sai-Jie; Zhang, Sai; Mao, Shuai; Xie, Xiao-Xiao; Xiao, Xue; Xin, Min-Hnag; Xuan, Wei; He, Yuan-Yuan; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 179 – 190;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

934-98-5, The dichloropyrimidine (3.29 gm, 0.01 moles) was dissolved in n-butanol (30 mL) and N-methyl-N’-(2-aminoethyl)piperazine (3.0 gm, 2.1 X 10″2 moles) was added. This mixture was heated to 1 15°C. forming a dark orange solution. After 2 hours, TLC (silica, 25percent methanol in methylene chloride) showed some remaining starting material along with a single product. Diisopropylethylamine (02.58 gm, 0.02 moles) was added along with additional N-methyl-N’- (2-aminoethyl)piperazine (1.0 gm, 7.0 X 10″3 moles) and this solution was heated at 1 15°C. for an additional 2 hours. After cooling the reaction was diluted with hexane (100 mL) and this solution was extracted with water (50 mL). The hexane solution was dried over magnesium sulfate, filtered and the solvents were removed under reduced pressure. The remaining orange solid was boiled in hexane (50 mL) and then cooled on ice. The solid was isolated by filtration, washed with hexane and dried. Yield was 3.0 gm, (55percent).

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANUS BIOTHERAPEUTICS, INC.; LIPFORD, Grayson, B.; ZEPP, Charles, M.; WO2012/167053; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of tert-butyl 4-((lR,3S,5aR,5bR,7aR,l laS,l lbR,13aR,13bR)- 5a,5b,8,8, 11 a-pentamethyl-3 a-((2-(4-methylpiperazin- 1 -yl)ethylamino)methyl)- 1 – (prop-l-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,l l,l la,l lb,12,13,13a,13b-octadecahydro- lH-cyclopenta[a]chrysen-9-yl)benzoate.To a solution of tert-butyl 4-((lR,3aS,5aR,5bR,7aR,l laS.l lbR,13aR,13bR)-3a- formyl-5a,5b,8,8,l la-pentamethyl-l-(prop-l-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,l l,l la,l lb,12,13,13a,13b-octadecahydro-lH- cyclopenta[a]chrysen-9-yl)benzoate (0.1 g, 0.167 mmo) in DCE (2 ml) was added acetic acid (0.019 ml, 0.334 mmol) and 2-(4-methyl-piperazin-l-yl)-ethylamine (0.048 g, 0.334 mmol). The mixture was stirred at rt for 2 h, then sodiumtriacetoxyborohydride (0.177 g, 0.835 mmol) was added and it was stirred at rt for 3 days. The mixture was diluted with 7 ml of sat. aHC03 and was extracted with dichloromethane (3 x 7 ml). The combined organic layers were dried with a2S04. The drying agent was removed by filtration and the filtrate was concentrated under reduced pressure. The crude product was used in the next with no additional purification. LCMS: m/e 726.5 (M+H)+, 3.07 min (method 6).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; REGUEIRO-REN, Alicia; SWIDORSKI, Jacob; SIT, Sing-Yuen; CHEN, Yan; CHEN, Jie; MEANWELL, Nicholas A.; LIU, Zheng; WO2012/106188; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of tert-butyl 4-((lR,3S,5aR,5bR,7aR,l laS,l lbR,13aR,13bR)- 5a,5b,8,8, 11 a-pentamethyl-3 a-((2-(4-methylpiperazin- 1 -yl)ethylamino)methyl)- 1 – (prop-l-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,l l,l la,l lb,12,13,13a,13b-octadecahydro- lH-cyclopenta[a]chrysen-9-yl)benzoate.To a solution of tert-butyl 4-((lR,3aS,5aR,5bR,7aR,l laS.l lbR,13aR,13bR)-3a- formyl-5a,5b,8,8,l la-pentamethyl-l-(prop-l-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,l l,l la,l lb,12,13,13a,13b-octadecahydro-lH- cyclopenta[a]chrysen-9-yl)benzoate (0.1 g, 0.167 mmo) in DCE (2 ml) was added acetic acid (0.019 ml, 0.334 mmol) and 2-(4-methyl-piperazin-l-yl)-ethylamine (0.048 g, 0.334 mmol). The mixture was stirred at rt for 2 h, then sodiumtriacetoxyborohydride (0.177 g, 0.835 mmol) was added and it was stirred at rt for 3 days. The mixture was diluted with 7 ml of sat. aHC03 and was extracted with dichloromethane (3 x 7 ml). The combined organic layers were dried with a2S04. The drying agent was removed by filtration and the filtrate was concentrated under reduced pressure. The crude product was used in the next with no additional purification. LCMS: m/e 726.5 (M+H)+, 3.07 min (method 6).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; REGUEIRO-REN, Alicia; SWIDORSKI, Jacob; SIT, Sing-Yuen; CHEN, Yan; CHEN, Jie; MEANWELL, Nicholas A.; LIU, Zheng; WO2012/106188; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

Example 53: -r2-(4-methv.-piDerazin-1 -vn-ethvi1-3-r3-(5-thioDhen-3-vi-Dvrimidin-2-viamino)-Dhenvt1-urea; To a stirring solution of W (100 mg, 0.23 mmol) in CH2CI2 (20 mL) was added J (33 mg, 0.23 mmol) followed by triethylamine (32 muL, 0.23 mmol). The solution was stirred at room temperature for 12 hours where the reaction was diluted with CH2Cl2 (50 mL) and washed with 2N NaOH (2 x 50 mL), water (2 x 50 mL) and brine (2 x 50 mL). The organics were dried over Na2S04 and concentrated in vacuo. The residue was purified using column chromatography (silica gel, 5percent MeOH in CH2CI2). The fractions containing product were evaporated to dryness under vacuum to yield compound 53 in 45percent yield as a white solid. (at)H NMR (300 MHz, CD30D) No. 2.27 (s, 3H), 2.33-2.55 (m, 7.01-7.02 (m, 1H), 7.04-7.05 (m, 2H), 7.43 (d, 1 H), 7.45 (d, 1 H), 7.64 (d, 1 H), 7.86 (d, 1 H), 8.72 (s, 2H). MS m/z 438 [M++1].

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; SUGEN, INC.; WO2005/113548; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

(i) 3-((4-((4-Aminonaphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-methoxy-N-(2-(4-methylpiperazin-1-yl)ethyl)benzamideHATU (200 mg, 0.526 mmol) was added to a solution of 3-((4-((4-((tert- butoxycarbonyl)amino)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-methoxybenzoic acid (see Fyfe, M. C. T. et al., WO 2014/162126; 200 mg, 0.398 mmol), 2-(4-methylpiperazin-1- yl)ethanamine (100 mg, 0.698 mmol) and Hunig’s Base (200 muIota_, 1.145 mmol) in DMF (2 mL). The reaction mixture was stirred at rt for 72h. The reaction mixture was partitioned between water (10 mL) and DCM (20 mL). The organics were separated, dried (MgSCu), filtered and evaporated to give a brown gum. This material was dissolved in IPA (2 mL) and HCI, 6N in IPA (2 mL, 12.00 mmol) was added. The reaction mixture was stirred overnight. The solvent was evaporated and the residue partitioned between sat. NaHCC>3 (10 mL) and DCM (20 mL). The organics were separated, dried (MgSO4), filtered and evaporated to afford the subtitle compound (200 mg) as a tan glass. LCMS m/z 528 (M+H)+(ES+)

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics