Category: 934-98-5

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Method B: Oxalyl chloride (2 M in CH2Cl2) was added dropwiseto an ice-cooled solution of 2 in dry CH2Cl2 under an argon atmosphere. After 1 h, the ice-bath was removed and the reaction batch was stirred overnight at ambient temperature in an atmosphere of Ar. Subsequently the solvent was evaporated in vacuo and the crude acyl chloride was dissolved in dry DMF and added dropwise to a stirred suspension of amine and K2CO3 in dry DMF at 0 °C. The stirring was continued for 1 h and then at ambient temperature overnight. After 20 h the suspension was filtered, the solvent evaporated, the residue taken up in water and extracted with CH2Cl2. The organic layer was washed with 5percent aqueous NaHCO3 and brine.Then it was dried over anhydrous sodium sulfate, filtered and the solvent was evaporated in vacuo yielding the raw quinoline-4-carboxamides 9?11, which were further purified by column chromatography., 934-98-5

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Hochegger, Patrick; Faist, Johanna; Seebacher, Werner; Saf, Robert; Maeser, Pascal; Kaiser, Marcel; Weis, Robert; Bioorganic and Medicinal Chemistry; vol. 25; 7; (2017); p. 2251 – 2259;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

(iii) 3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfinyl)phenyl)ureido)naphthalen-1- yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(2-(4-methylpiperazin-1-yl)ethyl)benzamideHATU (150 mg, 0.394 mmol) was added to a solution of the product from step (ii) above (200 mg, 0.284 mmol), 2-(4-methylpiperazin-1-yl)ethanamine (60 mg, 0.419 mmol) and diisopropylethylamine (150 L, 0.859 mmol) in DMF (2 mL). The reaction mixture was stirred at rt for 72h. Water (10 mL) added and the resulting solid filtered off, washed with water (2 mL) and dried to afford the title compound (0.19 g). 1H NMR (400 MHz, DMSO-ds) delta 9.41 (s, 1 H), 9.07 (s, 1 H), 8.96 (s, 1 H), 8.51 (d, 1 H), 8.28 (d, 1 H), 8.21 (t, 1 H), 8.12 (d, 1 H), 8.10 (d, 1 H), 7.88 (d, 1 H), 7.77-7.67 (m, 1 H), 7.66-7.58 (m, 1 H), 7.56 (t, 1 H), 7.50 (t, 1 H), 7.40 (d, 1 H), 7.36 (d, 1 H), 6.86 (dd, 1 H), 6.58 (dd, 1 H), 6.14 (d, 1 H), 3.87 (s, 3H), 3.74 (s, 3H), 2.79 (s, 3H), 2.43 (t, 2H), 2.32 (s, br, 10H), 2.15 (s, 3H), 1.32 (s, 9H). LCMS m/z 794 (M+H)+(ES+)

934-98-5, As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

General procedure: General procedure: a suspension of the indenoquinoline 20 or 23(1.67 mmol) and the appropriated amine (3.33 mmol) in 7 ml ofdry pyridine was heated at 100 C for 20 h. The reaction mixturewas poured into iced water (150?200 ml) and when it was possible,the precipitate was filtered, otherwise it was extracted withethyl acetate or dichloromethane. The organic layer was dried withanhydrous Na2SO4 and evaporated to dryness. The residue waspurified by CC (silica gel; CH2Cl2/MeOH or cyclohexane/ethyl acetatein gradient as indicated for each compound).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Article; Barteselli, Anna; Parapini, Silvia; Basilico, Nicoletta; Mommo, Danilo; Sparatore, Anna; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5757 – 5765;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

934-98-5, General procedure: A mixture of celastrol (45mg, 0.1mmol), BOP (53mg, 0.12mmol), DIEA (53muL, 0.3mmol) and 2-dimethylaminoethylamine (28muL, 0.3mmol) in DCM (5.0mL) was stirred at room temperature overnight. Then the mixture was concentrated and purified by normal phase column chromatography (DCM/MeOH=30:1) to afford the target compound as a red solid (35mg, 75.6percent).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Article; Jiang, Fen; Wang, Hui-Jie; Bao, Qi-Chao; Wang, Lei; Jin, Yu-Hui; Zhang, Qiong; Jiang, Di; You, Qi-Dong; Xu, Xiao-Li; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5431 – 5439;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Spirothiazamenthane 3 (1.0 eq) was dissolved in toluene (0.1 M concentration) in a microwave vial and the solution was treated with amine (10 eq) and PTSA (20 mol percent). This mixture was heated at 150 °C using microwaves for 4 h. After cooling, the solvents were removed by evaporation and the resulting residue was taken up in 1:1 Et2O/2M NaOH. The layers were separated and the aqueous layer was extracted 2 × with Et2O. The organic layers were combined, dried over Na2SO4, filtered and concentrated. The resulting crude products were purified as described below. Variations in reaction conditions are also noted below.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Arns, Steve; Balgi, Aruna D.; Shimizu, Yoko; Pfeifer, Tom A.; Kumar, Nag; Shidmoossavee, Fahimeh S.; Sun, Sharon; Tai, Sheldon S.-H.; Agafitei, Olga; Jaquith, James B.; Bourque, Elyse; Niikura, Masahiro; Roberge, Michel; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 64 – 73;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 58: 2-[2-( 4-methvl-piperazin-1-vl)-ethvlami no l-N-[3-( 5-thiophen-3-vl-pvrimidin-2-vlamino )- phenyl] acetamide; To a stirring solution of U (200 mg, 0.58 mmol) in CH3CN (100 mL) was added J (486 mg, 3.48 mmol) followed by diisopropylethylamine (300 muL, 1.74 mmol). The solution was brought to reflux and monitored by tic analysis. After 13 hours the solvent was removed in vacuo and the residue purified via column chromatography (silica gel, 9:1 CH2CI2/MeOH). The fractions containing product were evaporated to dryness under vacuum to yield compound 58 in 44percent yield as a white crystalline solid. 1H NMR (300 MHz, CDCl3) No. 2.27 (s, 3H), 2.27-2.46 (m, 10H), 2.5-2.54 (m, 2H), 3.39 (s, 2H), 7.2-7.46 (m, 11 H), 8.09 (s, 1 H), 8.67 (s, 2H), 9.42 (s, 1H). MS m/z 452 [M++1]., 934-98-5

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; SUGEN, INC.; WO2005/113548; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

934-98-5, General procedure: General Procedure 5: [000565] The compounds of the application with the general formula shown below can be prepared according to the synthetic scheme shown in Scheme 5. Scheme 5 [000566] To a solution of compound (II) or (II?) (1 equivalent) in N,N-dimethyl-formamide (DMF) is added 2 equivalents of N,N-diisopropylethylamine (DIPEA) and 2.2 equivalent of 2-(4- methylpiperazin-1-yl)ethanamine (VIa). The reaction mixture is stirred at about 15 oC to about 28 oC for about 6 hours to about 24 hours. The reaction mixture is diluted with water, washed with ethyl acetate, washed with brine, dried over Mg2SO4, filtered and evaporated to give a crude compound which is then purified by silica gel column using a mixture of Chloroform:Methanol (9:1) as eluent. The product is collected under reduced pressure to provide the compound with the general formula shown in Scheme 5. [000567] Compounds 47-65, 101, 107-110, and 114-117 were prepared according to General Procedure 5 substituting (II) or (II?) with the appropriate substituted compound. Example 116: [000568] Synthesis of 2-benzamido-N-(2-(4-methylpiperazin-1-yl)ethyl)benzamide (47) [000569] Compound 47 was obtained as a white powder in 88percent yield. 1H-NMR (500MHz, CDCl3): delta 12.28 (s, 1H, ArNHCO), 8.86 (dd, J = 8.5, 0.8 1H, CONHCH2), 8.07 (dd, J = 8.2, 1.3, 2H), 7.58-7.51 (m, 5H), 7.16 (td, J = 7.6, 0.9, 1H), 7.07 (s, 1H), 3.57 (q, J = 5.45, 2H, NHCH2CH2), 2.66 (t, J = 5.45, 2H, NHCH2CH2), 2.64-2.38 (m, 8H), 2.34 (s, 3H, CH3). 13C- NMR (126 MHz, CDCl3): delta 169.11 (ArC=O), 165.57 (ArC=O), 140.17 (ArC), 134.92 (ArC), 132.69 (ArCH), 131.78 (ArCH), 128.75 (ArCH), 127.41 (ArCH), 126.56 (ArCH), 122.84 (ArCH), 121.62 (ArCH), 120.42 (ArC), 55.90 (CH2), 55.10 (CH2), 52.66 (CH2), 45.92 (CH3), 36.27 (CH2). MS (ESI): 367.2 [M+1]. m.p. (from ethanol/water): 80 oC.

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED; WESTWELL, Andrew, David; BRANCALE, Andrea; CLARKSON, Richard, William Ernest; (247 pag.)WO2016/16728; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

100 mg of intermediate I-24 was dissolved in resulfured dry DMF,Twelve mg of palladium acetate and 36 mg of DPPP (1,3-bis(diphenylphosphino)propane) were added under nitrogen protection.After stirring for 5 minutes,Withdrawal of nitrogen,Charge CO,After multiple replacements,400 mul of triethylamine and 186 mg of 2-(4-methylpiperazin-1-yl)ethanamine are added,Stir overnight at 80 °C in an oil bath.TLC showed that after the reaction,Take CO,Evaporate the reaction solution under reduced pressureTo the residue was added 30 ml of ethyl acetate and 20 ml of water.Insoluble material was removed by filtration.The filtrate is extracted and separated from the organic layer.dry,Column chromatography after concentration gave 83 mg of compound C-4 (oil, yield 61percent).

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Geng Meiyu; Xing Weiqiang; Ding Jian; Ai Jing; (86 pag.)CN103664895; (2018); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

A solution of 2,4-dichloro-5,7-difluoro-3-nitroquinoline (5.58 gm, 2.0×10?2 moles) in 2-methyl tetrahydrofuran (50 mL) is stirred as diisopropylethylamine (2.84 gm, 2.2×10?2 moles) and N-2-aminoethyl-N? methylpiperazine (3.15 gm, 2.2×10?2 moles) are added. This solution is stirred at room temperature overnight. The yellow reaction mixture is diluted with more 2-methyl-tetrahydrofuran (50 mL) and this is washed with water (100 mL) followed by brine (50 mL). After being dried over magnesium sulfate, the solution is filtered and the solvent is removed under reduced pressure. The oily residue is stirred with diethyl ether (25 mL) and this is cooled on ice causing the product to crystallize. The solid yellow product is isolated by filtration, washed with ether and dried. The yield is about 4.32 gm.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANUS BIOTHERAPEUTICS, INC.; Lipford, Grayson B.; Zepp, Charles M.; (72 pag.)US9873694; (2018); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

General procedure: In a schlenk-type flask, a mixture of Pd2(dba)3 (0.023 g, 0.025mmol) and XantPhos (0.015 g, 0.025 mmol) in dry dioxane wasstirred at room temperature for 5 min. Then, NHR (2 mmol) andCs2CO3 (0.24 g, 0.75 mmol) were added and stirred for another 5min at ambient temperature. Afterwards, E-6 (F-4) (0.5 mmol)was added, and the flask was evacuated and backfilled with nitrogenfor three times. The reaction mixture was stirred at 100 C for9 h and followed by TLC until completion. After cooling, the solventwas removed under reduced pressure. The residue was purified byflash column chromatography with ethyl acetate/petroleum etherto afford compounds E-a?E-k (F-a?F-j). White solid, yield 31percent, mp: 144?146 C; 1H NMR (400 MHz,CDCl3) d: 7.51 (d, J = 1.6 Hz, 4H, PhH), 7.33 (d, J = 16 Hz, 1H, CH),7.20 (s, 2H, PhH), 6.96 (s, 1H, NH), 5.83 (d, J = 16.6 Hz, 1H, CH),5.62 (s, 1H, pyridine-H), 5.35 (s, 1H, pyridine-H), 3.34 (s, 2H,CH2), 2.80 (s, 4H, CH2), 2.68 (s, 2H, CH2), 2.45 (s, 3H, CH3), 2.14(s, 6H, CH3), 1.89 (s, 2H, CH2), 1.25 (s, 2H, CH2); 13C NMR (100MHz, CDCl3) d: 152.7, 149.8, 133.2, 132.3, 128.2, 117.9, 96.0,86.2, 51.7, 44.9, 16.3; ESI?MS: 508.2 [M+H+]. C30H33N7O (507.27)., 934-98-5

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Lu, Xueyi; Yang, Jiapei; Kang, Dongwei; Gao, Ping; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 2051 – 2060;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics