Category: 934-98-5

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 250 mL round bottom flask equipped with a stir bar was charged with Example 1U (1.96 g) and anhydrous dichloromethane (160 mL) at room temperature under nitrogen. The mixture was cooled to 0¡ã C. in an ice bath, and 2-(4-methylpiperazin-1-yl)ethanamine (0.395 mL) was added via a syringe. The mixture was stirred for 25 minutes at 0¡ã C., and sodium triacetoxyborohydride (156 mg) was added as a solid. The reaction mixture was stirred for 15 minutes at 0¡ã C., and powdered activated 3 angstrom molecular sieves were added (1.96 g). The reaction mixture was stirred 2 hours at 0¡ã C., and was allowed to stir and warm slowly to room temperature overnight. LC/MS indicated one major peak with a mass that corresponded to desired product. The reaction mixture was quenched with dichloromethane and water. The layers were separated, and aqueous layer was extracted with dichloromethane and 10percent methanol/dichloromethane. The aqueous layer was neutralized with saturated aqueous NaHCO3 mixture, and was extracted one more time with 10percent methanol/dichloromethane. The combined extracts were washed with saturated aqueous NaHCO3 and brine, dried with Na2SO4, filtered, and concentrated. The residue was dissolved in dichloromethane and was purified on a Grace Reveleris X2 MPLC using a Teledyne Isco RediSep? Rf gold 750 g silica gel column eluting with a gradient of 0-20percent of methanol/dichloromethane over 40 minutes. The mixed fractions were purified on a Grace Reveleris X2 MPLC using a Teledyne Isco RediSep? Rf gold 330 g silica gel column eluting with a ramp of 0-15percent of methanol/dichloromethane over 40 minutes to collect additional title compound. The material from both columns was combined to provide the title compound. 1H NMR (501 MHz, dimethyl sulfoxide-d6) delta ppm 8.61 (m, 2H), 7.47 (m, 2H), 7.39 (d, 1H), 7.17 (m, 7H), 7.04 (td, 1H), 6.96 (dd, 1H), 6.67 (d, 1H), 6.51 (d, 1H), 5.84 (dd, 1H), 5.06 (m, 2H), 4.07 (ddq, 2H), 3.90 (d, 1H), 3.75 (s, 3H), 3.68 (dd, 2H), 3.50 (d, 1H), 3.17 (m, 1H), 3.08 (m, 1H), 2.90 (m, 2H), 2.65-2.20 (m, 10H), 2.14 (s, 3H), 1.67 (s, 3H), 1.09 (t, 3H). MS (ESI) m/z 928.4 (M+H)+., 934-98-5

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG; Brady, Patrick B.; Braje, Wilfried; Dai, Yujia; Doherty, George A.; Gong, Jane; Jantos, Katja; Ji, Cheng; Judd, Andrew S.; Kunzer, Aaron R.; Lai, Chunqiu; Mastracchio, Anthony; Risi, Roberto M.; Song, Xiaohong; Souers, Andrew J.; Sullivan, Gerard M.; Tao, Zhi-Fu; Teske, Jesse A.; Wang, Xilu; Wendt, Michael D.; Yu, Yiyun; Zhu, Guidong; Penning, Thomas D.; (218 pag.)US2019/55264; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

934-98-5, General procedure: A suspension oftert-butyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-formyl-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate5(1 eq.), the corresponding amine (2 eq.) and acetic acid (2 – 5 eq.) in DCE (2 ml) was stirred at RT for 30 min.To this suspension was added sodium triacetoxyborohydride (5 eq.).The resulted mixture was stirred at RT for 18 – 72 hrs.The reaction mixture was diluted with 5 ml of saturated sodium carbonate and extracted with DCM (3 x 10 ml).The combined organic layers were dried over sodium sulfate, filtered and concentratedinvacuo.The crude product was purified by Biotage flash chromatography or was used directly in the next step without further purification.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Yan; Sit, Sing-Yuen; Chen, Jie; Swidorski, Jacob J.; Liu, Zheng; Sin, Ny; Venables, Brian L.; Parker, Dawn D.; Nowicka-Sans, Beata; Lin, Zeyu; Li, Zhufang; Terry, Brian J.; Protack, Tricia; Rahematpura, Sandhya; Hanumegowda, Umesh; Jenkins, Susan; Krystal, Mark; Dicker, Ira D.; Meanwell, Nicholas A.; Regueiro-Ren, Alicia; Bioorganic and Medicinal Chemistry Letters; vol. 28; 9; (2018); p. 1550 – 1557;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

General procedure: To the suspension of sodium hydride (60percent, 0.23 g, 5.66 mmol) in dried dimethyl formamide (15 mL) was added 6-bromo (or 7-bromo)-[1,2,4]triazolo[1,5-a]pyridin-2-amine (0.60 g, 2.82 mmol),stirred for 10 min at room temperature, added N,N’-carbonyldimidazole(CDI, 1.37 g, 8.46 mmol), stirred at 60 ¡ãC until the starting material consumed, then added amine (9.87 mmol) and stirred at 60 ¡ãC for 6 h. The volatile was removed under reduced pressure to give a white pale yellow residue. Water (30 mL) was added tothe residue. The mixture was stirred. The precipitate was collected by filtration, dried to afford the expected product as a white solid. 5.1.1.7 1-(6-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-3-(2-(4-methylpiperazin-1-yl)ethyl)urea (2g) White solid; yield: 81.0percent; mp: 182-184 ¡ãC; 1H NMR (CDCl3): delta 9.60 (s, 1H, NH), 8.80 (s, 1H, Ar-H), 8.46 (s, 1H, NH), 7.63 (m, 2H, Ar-H), 2.60 (m, 10H, CH2 * 5), 2.36 (s, 3H, CH3). MS m/z (ESI): 382.1 [M+H]+.

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Article; Wang, Xiao-Meng; Mao, Shuai; Cao, Lei; Xie, Xiao-Xiao; Xin, Min-Hang; Lian, Jia-Fang; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5662 – 5671;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

To a 10 ml RBF containing a magnetic stir bar was added 2-(4- Methylpiperazine-l-yl)ethanamine (143 mg, 1 mmol) in DCM (1 ml). Let stir under argon at room temperature. 1 , 1′-Carbonyldiimidazole (207 mg, 0.5 mmol) was added to the above solution using a spatula. Started forming a white precipitate. TLC on Sipsi2 in 100percent MeOH against the imidazolde indicated a very polar product.Let the solution stir overnight under argon. TLC indicated the completion of the reaction. Extracted the mixture into 25 ml EtOAc. Washed with 2×20 ml of distilled water and 20 ml brine. Combined the desired fractions and dried over anhydrous MgSOphi Filtered and concentrated in vacuo. Dissolved in the minimumamount of EtOAc and reprecipitated from hexanes. Filtered the product as a colorless solid and dried under vacuum to obtain a 69percent yield.eta and 13C NMR in CDCl3 with 2 drops of MeOD. Sample was designated NTF-2006-1-006A1FfNMR (300 MHz, CDCl3) 0.78 (t, J= 7.5 Hz, 3H), 1.08 (m, J= 7.5 Hz, 2H),1.38 (m, J= 7.5 Hz,4H), 1.47 (br s, 4H), 2.27 (s, 3H), 2.47 (br t,4H),2.54 (br t, 4H), 2.60 (t, J=6 Hz, 3H), 3.08 (m, J= 9.0 Hz, 2H), 3.52 (m, J= 5.7 Hz, 2H), 6.89 (d, J= 9.0 Hz, 2H), 7.07 (t, J= 6.9 Hz, IH), 7.28 (t, J= 8.4 Hz, 2H), 7.45 ( br d,J=1.8 Hz, IH), 7.55 (br d, IH) EPO 13C NMR (75 MHz, CDCl3) 14.00, 20,16, 31.32, 36.84, 43.26, 43.36, 46.23,53.07, 55.21, 56.99, 112.96, 115.64, 124.05, 130.44, 132.81, 136.18, 142.79, 142.84, 156.20FABMS 490 (M+H)+ ;HRMS calcd for 024H36N5O4S+ 489.2410 ; found 490.2510

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; FLYNN, Gary, A.; YOOL, Andrea, J.; MIGLIATI, Elton, Rodrigues; RITTER, Leslie, S.; WO2008/52190; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

To a 10 ml RBF containing a magnetic stir bar was added 2-(4- Methylpiperazine-l-yl)ethanamine (143 mg, 1 mmol) in DCM (1 ml). Let stir under argon at room temperature. 1 , 1′-Carbonyldiimidazole (207 mg, 0.5 mmol) was added to the above solution using a spatula. Started forming a white precipitate. TLC on Sipsi2 in 100percent MeOH against the imidazolde indicated a very polar product.Let the solution stir overnight under argon. TLC indicated the completion of the reaction. Extracted the mixture into 25 ml EtOAc. Washed with 2×20 ml of distilled water and 20 ml brine. Combined the desired fractions and dried over anhydrous MgSOphi Filtered and concentrated in vacuo. Dissolved in the minimumamount of EtOAc and reprecipitated from hexanes. Filtered the product as a colorless solid and dried under vacuum to obtain a 69percent yield.eta and 13C NMR in CDCl3 with 2 drops of MeOD. Sample was designated NTF-2006-1-006A1FfNMR (300 MHz, CDCl3) 0.78 (t, J= 7.5 Hz, 3H), 1.08 (m, J= 7.5 Hz, 2H),1.38 (m, J= 7.5 Hz,4H), 1.47 (br s, 4H), 2.27 (s, 3H), 2.47 (br t,4H),2.54 (br t, 4H), 2.60 (t, J=6 Hz, 3H), 3.08 (m, J= 9.0 Hz, 2H), 3.52 (m, J= 5.7 Hz, 2H), 6.89 (d, J= 9.0 Hz, 2H), 7.07 (t, J= 6.9 Hz, IH), 7.28 (t, J= 8.4 Hz, 2H), 7.45 ( br d,J=1.8 Hz, IH), 7.55 (br d, IH) EPO 13C NMR (75 MHz, CDCl3) 14.00, 20,16, 31.32, 36.84, 43.26, 43.36, 46.23,53.07, 55.21, 56.99, 112.96, 115.64, 124.05, 130.44, 132.81, 136.18, 142.79, 142.84, 156.20FABMS 490 (M+H)+ ;HRMS calcd for 024H36N5O4S+ 489.2410 ; found 490.2510

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; FLYNN, Gary, A.; YOOL, Andrea, J.; MIGLIATI, Elton, Rodrigues; RITTER, Leslie, S.; WO2008/52190; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

General procedure: To the suspension of sodium hydride (60percent, 0.23 g, 5.66 mmol) in dried dimethyl formamide (15 mL) was added 6-bromo (or 7-bromo)-[1,2,4]triazolo[1,5-a]pyridin-2-amine (0.60 g, 2.82 mmol),stirred for 10 min at room temperature, added N,N’-carbonyldimidazole(CDI, 1.37 g, 8.46 mmol), stirred at 60 ¡ãC until the starting material consumed, then added amine (9.87 mmol) and stirred at 60 ¡ãC for 6 h. The volatile was removed under reduced pressure to give a white pale yellow residue. Water (30 mL) was added tothe residue. The mixture was stirred. The precipitate was collected by filtration, dried to afford the expected product as a white solid. 5.1.1.7 1-(6-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-3-(2-(4-methylpiperazin-1-yl)ethyl)urea (2g) White solid; yield: 81.0percent; mp: 182-184 ¡ãC; 1H NMR (CDCl3): delta 9.60 (s, 1H, NH), 8.80 (s, 1H, Ar-H), 8.46 (s, 1H, NH), 7.63 (m, 2H, Ar-H), 2.60 (m, 10H, CH2 * 5), 2.36 (s, 3H, CH3). MS m/z (ESI): 382.1 [M+H]+.

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Article; Wang, Xiao-Meng; Mao, Shuai; Cao, Lei; Xie, Xiao-Xiao; Xin, Min-Hang; Lian, Jia-Fang; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5662 – 5671;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

934-98-5, General procedure: General procedure: Hydroxylamine hydrochloride (1.58 mmol)and sodium hydroxide (2.65 mmol) were added to an ice-cooledsuspension of the proper ketone compound (0.53 mmol) in 10 mlof a mixture of ethanol/H2O (2:1). After stirring for 15 min at rt,the mixture was refluxed for 2 h. The ethanol was evaporatedand the alkaline aqueous solution was neutralized with 1N HCl.When possible, the obtained suspension was filtered and the aqueoussolution was extracted with CH2Cl2 and the organic layer wasdried with anhydrous Na2SO4 and evaporated to dryness. Thecrude residue was purified as indicated for each compound.

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Barteselli, Anna; Parapini, Silvia; Basilico, Nicoletta; Mommo, Danilo; Sparatore, Anna; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5757 – 5765;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00100] Step 8. To a solution of 2-((lH-indol-3-yl)methyl)-5-amino-3-butylphenol (2 g, 6.8 mmol) and diisopropylethylamine (0.9 g, 6.8 mmol) in 40 mL of THF, was added 4-nitrophenyl chloroformate (1.4 g, 6.8 mmol). The solution was stirred for 30 min and then 2-(4- methylpiperazin-l-yl)ethanamine (1.9 g, 13.6 mmol) was added at room temperature. The reaction mixture was stirred at room temperature for 2 h. After the reaction mixture was concentrated, the residue was purified by preparative HPLC to afford l-(4-((lH-indol-3- yl)methyl)-3-butyl-5-hydroxyphenyl)-3-(2-(4-methylpiperazin-l-yl)ethyl)urea (3.4 g, 36percent, 3 batches) as a white solid. 1H NMR (400 MHz, DMSO) delta: 0.75-0.79 (t, 3H), 1.21 (m, 2H), 1.23 (m, 2H), 2.20 (m, 3H), 2.34-2.43 (m, 10H), 2.47-2.50 (m, 2H), 3.15-3.16 (d, J = 6.0 Hz, 2H), 3.86 (s, 2H), 5.95 (s, 1H), 6.54-6.55 (d, J = 2.0 Hz, 1H), 6.66 (d, J = 2.0 Hz, 1H), 6.90 (s, 1H), 6.95 (d, J = 2.0 Etazeta,IotaEta), 7.00 (s, 1H), 7.26 (d, J = 8.4 Etazeta,IotaEta), 7.55 (d, J = 7.6 Hz, 1H), 8.38 (s, 1H), 9.10 (s, 1H), 10.60 (d, J = 1.6 Hz, 1H).

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; WO2013/148365; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

To a solution of EXAMPLE 26B (74 mg, 0.15 mmol) in dichloromethane (10 mL) was added 2-(4-methylpiperazin-l -yl)ethanamine (11 1 mg, 0.78 mmol), 2-(7-aza-lH- benzotriazole-l -yl)-l, l ,3,3-tetramethyluronium (1 18 mg, 0.312 mmol) and triethylamine (79 mg, 0.78 mmol). After stirring at ambient temperature for 2 hours, the mixture was poured into water (30 mL) and extracted with dichloromethane (30 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered, concentrated and purified by preparative HPLC using a gradient of 10/90 to 90/10 acetronitrile in water (containing 0.1 percent trifluoroacetic acid) to give the title compound. NMR (DMSO-ak, 300 MHz): delta ppm 12.29 (s, 1 H), 1 1.60 (s, 1 H), 8.35 – 8.31 (m, 2 H), 7.58 (d, J = 8.1 Hz, 2 H), 7.42 – 7.38 (m, 3 H), 7.20 (d, J = 8.7 Hz, 1 H), 6.84 (s, 1 H), 6.47 (d, ./ = 7.5 Hz, 1 H), 4.44 (s, 2 H), 3.93 (s, 3 H), 3.00 (s, 3 H), 2.55 (bra, 12 H). MS 595.2 (M + H ).

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97683; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

934-98-5, To a disposable tube with stir bar was added tert-butyl 3-(4-chloro-3-(2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate (100 mg, 153 mumol, Eq: 1.00) (from Example 116 supra), DMF (0.5 mL) and then 2-(4-methylpiperazin-1-yl)ethanamine (437 mg, 3.05 mmol, Eq: 20). The reaction was heated at 75¡ã C. in a pre-heated oil bath for 3 hours, after which it was cooled to room temperature. The reaction was then diluted with water, the solid was filtered off and then rinsed with water and then diethyl ether to provide after drying tert-butyl 3-(4-chloro-3-(2-(2-(4-methylpiperazin-1-yl)ethylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropyl-carbamate. (Yield 74 mg, 68percent).LR-MS [M+H]+: 718.

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Patent; Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael; US2012/184542; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics