Category: 934-98-5piperazines

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

A mixture of (S)-isopropyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-S -(4-(4-fluorophenethoxy)phenyl)-2-methyl-6-(((trifluoromethyl)sulfonyl)oxy)pyridin-3 -yl)acetate (0.02 g, 0.027 mmol) and 2-(4-methylpiperazin-1-yl)ethanamine (0.0 16 g,0.108 mmol) in NMP (1 mL) was heated at 180 °C for 2 h. Ethanol (0.5 mL) and 5 MNaOH (0.054 mL, 0.271 mmol) were added and the mixture was heated at 80 °C for 4.5cooled to ambient temperature, and filtered. The cmde mixture was purified viapreparative HPLC to afford the desired product (11.8 mg, 62percent). LCMS (M+1) = 690.2.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

General procedure: To a solution of 2 (0.6 mmol) in MeOH/H2O/DMSO=2:1:1(4 mL)was added sodium hydroxide (6 mmol). The solution was warmed to 45 C, after being stirred for overnight, the mixture allowed to cool, and the MeOH was removed by rotary evaporation. To the resultant slurry 1M HCl was added, and the pH was adjusted to 4. Subsequently, the mixture was filtered and washed thoroughly with water, dried to afford a white solid, which was used without additional purification. A mixture of above acid (0.3 mmol), HOBt (0.36 mmol), EDCI (0.36 mmol)were dissolved in dry DMF(3 mL), and stirred for 20 min. Then, amine(0.6 mmol) were added, the mixture was stirred for overnight, diluted with EtOAc, washed with water (30 mL¡Á5), dried over anhydrous Na2SO4, filtered and evaporated under-reduced pressure. The crude product was purified by silica gel column chromatography to afford the corresponding product 3-26.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xiao, Xiao; Xu, Mei; Yang, Chao; Yao, Yao; Liang, Li-na; ED Chung, Philip; Long, Qun; Zacksenhaus, Eldad; He, Zhixu; Liu, Sheng; Ben-David, Yaacov; Bioorganic and Medicinal Chemistry; vol. 26; 23-24; (2018); p. 6096 – 6104;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

General procedure: I-c (0.6 g, 2.8 mM), 2-methoxyethanol (1.3 g, 17 mM) and sodium hydride (0.1 g, 2.8 mM, 60percent) in ethanol were heated to reflux for 5 h. The mixture was evaporated in vacuo and purified by silica gel column chromatography to get I-d-02 (0.6 g, 78.5percent) as a white solid., 934-98-5

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Article; Wang, Lu; Zhang, Qing; Zhu, Gaoyuan; Zhang, Zhimin; Zhi, Yanle; Zhang, Li; Mao, Tianxiao; Zhou, Xiang; Chen, Yadong; Lu, Tao; Tang, Weifang; European Journal of Medicinal Chemistry; vol. 130; (2017); p. 86 – 106;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

Will 97 (0.30g, 0.88mmol),EDC.HCl (0.25 g, 1.32 mmol),HOBt (0.14 g, 1.06 mmol),A mixture of NMM (0.23 ml, 2.11 mmol) and DMF (2.5 ml) was stirred for a while, then 2-(4-methylhexahydropyrazin-1-yl)ethanamine (0.16 ml, 1.06) was added thereto at room temperature. Mmol) and stir overnight.The residue was purified by flash column on silica gel (dichloromethane:methanol=9:1, Rf=0.19) to give 49 (0.08 g, 19.47percent) as a red solid.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAIPEI MEDICAL UNIVERSITY (TW); YEN, YUN (US); LIOU, JING PING (TW); PAN, SHIOW LIN (TW); (56 pag.)TW2018/5267; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

934-98-5, The mixture of 4-(4-chloro-1,6-naphthyridin-2-yl)-N,N-diethylbenzamide (150 mg, 0.44 mmol), 2-(4-methylpiperazin-1-yl)ethanamine (94 mg, 0.66 mmol) and K2C03 (121 mg, 0.88 mmol) in DMF (1 mL) was heated at 100¡ãC for l8hrs. The reaction mixture was poured into water (20 mL), extracted with EA (10 mL x 3). The combined organic layers were washed by water (10 mL x 3) and brine (10 mL), dried over Na2SO4. The drying agent was filtered off and the filtrate was concentrated under the reduced pressure to give the residue which was purified prep-TLC to afford N,N-diethyl-4-(4- (2-(4-methylpiperazin- 1 -yl)ethylamino)- 1 ,6-naphthyridin-2-yl)benzamide. (8 mg, 4percent). HPLC/UV purity:100percent; LC-MS (ESI): 447.2 (M + 1). ?H NMR (METHANOL-d4) oe: 9.76 (s, 1H), 8.90 (d, J = 6.2 Hz, 1H), 8.08 – 8.17 (d, J = 8.3 Hz, 2H), 7.93 (d, J = 6.2 Hz, 1H), 7.64 – 7.74 (d, J = 8.3 Hz, 2H), 7.30 (s, 1H),3.95 (t, J = 6.2 Hz, 2H), 3.63 (q, J = 6.8 Hz, 2H), 3.32 – 3.47 (m, 10H), 3.06 (t, J = 6.2 Hz, 2H), 2.92 (s,3H), 1.32 (t, J = 7.0 Hz, 3H), 1.18 (t, J = 7.0 Hz, 3H).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; PINKERTON, Anthony B.; ARDECKY, Robert J.; ZOU, Jiwen; (256 pag.)WO2018/204176; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

934-98-5, Example 42G ethyl (7R,20S)-18-chloro-10-{[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}-19-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-1-(prop-1-yn-1-yl)-7,8,15,16-tetrahydro-14H-17,20-etheno-13,9-(metheno)-6-oxa-2-thia-3,5,15-triazacyclooctadeca[1,2,3-cd]indene-7-carboxylate To a mixture of Example 42F (100 mg) in 13 mL dichloromethane at 0¡ã C. were added 50 mg 4 A molecular sieves and sodium triacetoxyborohydride (84 mg) followed by 2-(4-methylpiperazin-1-yl)ethanamine (19.68 muL). The mixture was stirred at room temperature for 3 hours, and was partitioned between saturated aqueous sodium bicarbonate mixture and dichloromethane. The aqueous phase was extracted with dichloromethane. The combined organic phases were dried over magnesium sulfate and filtered. The filtrate was concentrated, and the residue was purified by silica gel chromatography, eluting with 5-12percent methanol in dichloromethane, to provide the title compound. MS (ESI) m/z 872.3 (M+H)+.

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG; Brady, Patrick B.; Braje, Wilfried; Dai, Yujia; Doherty, George A.; Gong, Jane; Jantos, Katja; Ji, Cheng; Judd, Andrew S.; Kunzer, Aaron R.; Lai, Chunqiu; Mastracchio, Anthony; Risi, Roberto M.; Song, Xiaohong; Souers, Andrew J.; Sullivan, Gerard M.; Tao, Zhi-Fu; Teske, Jesse A.; Wang, Xilu; Wendt, Michael D.; Yu, Yiyun; Zhu, Guidong; Penning, Thomas D.; (218 pag.)US2019/55264; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 15-chloro-3-(3-fury)-N-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indole-2-carboxamideA DMF solution (340 mL) containing the compound obtained in Production example 1-3 (11.6 g), 2-(4-methylpiperazin-1-yl)ethylamine (7.0 g) and HATU (18.5 g) was ice-cooled to 15¡ã C., and diisopropylethylamine (23.2 mL) was added thereto and the resulting solution was stirred overnight at room temperature.The reaction solution was poured into water (1.5 L), and the mixture was stirred at room temperature for 5 minutes.A precipitate was collected by filtration and washed with water and then dissolved in chloroform (600 mL).The chloroform layer was washed with a saturated aqueous sodium hydrogen carbonate solution and then dried over anhydrous magnesium sulfate.The solvent was distilled off under reduced pressure, and the resulting residue was purified by NH-silica gel column chromatography (hexane:ethyl acetate=2:1 to 1:3), whereby the title compound (8.8 g) was obtained as a pale yellow solid.1H-NMR (400 MHz, CDCl3, deltappm): 2.30 (3H, s), 2.32-2.50 (8H, m), 2.47 (2H, t, J=5.8 Hz), 3.51 (2H, dt, J=5.8 Hz, 5.8 Hz), 6.63 (1H, dd, J=1.9, 0.9 Hz), 7.03 (1H, br s), 7.25 (1H, m), 7.39 (1H, dd, J=8.8 Hz, 0.6 Hz), 7.49 (1H, m), 7.66 (1H, m), 7.70 (1H, m), 9.78 (1H, s).ESI-MS Found: m/z 387[M+H]+

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MSD K.K; US2012/28990; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics