115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-(3-(7-Chloro-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-4-methylphenyl)-3-(2-methoxyphenyl)urea (80 mg, 0.17 mmol) was dissolved in 2-butanol (0.85 mL). 4-(4-Ethylpiperazin-1-yl)aniline (38 mg, 0.19 mmol) and potassium carbonate (70.5 mg, 0.51 mmol) were added, the reaction vessel was transferred into an oil bath heated to 110 C., and Pd2(dba)3 (31 mg, 0.03 mmol) and Xphos (16.2 mg, 0.03 mmol) were added and stirred for 90 minutes. Then, when the reaction was completed, the reaction mixture was filtered using a celite pad and concentrated. The residue was purified by MPLC to obtain the desired compound (73.2 mg, 66.8%) as a white solid. Based on the method of Representative Synthesis Example 2, the compounds represented by Compound Nos. 11 to 18 were synthesized.
The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; SIM, Tae Bo; HUR, Woo Young; YOON, Ho Jong; SONG, Chi Man; JU, Eun Hye; CHO, Han na; CHOI, Hwan Geun; (17 pag.)US2018/65970; (2018); A1;,
Piperazine – Wikipedia
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