Tag: 159.0575

Pfister, William R. et al. published their research in National SAMPE Symposium and Exhibition, [Proceedings] in 1985 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of Piperazine Dihydrochloride

Silicone-based sustained- and controlled-release drug delivery systems was written by Pfister, William R.;Sweet, Randall P.;Walters, Patrick A.. And the article was included in National SAMPE Symposium and Exhibition, [Proceedings] in 1985.Application In Synthesis of Piperazine Dihydrochloride This article mentions the following:

The effects of various classes of therapeutic agents and pharmaceutical excipients on the cure profile and phys. properties of vulcanized liquid silicone rubber (LSR) were evaluated. The results demonstrate the compatibility of LSR as a carrier matrix for a number of classes of therapeutic agents and pharmaceutical excipients. The resultant phys. properties of the LSR drug/excipient matrix are dependent upon the chem. structure and weight percentage loading level of the additive. These studies demonstrate the utility of LSR for fabricating controlled-release drug delivery systems. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Application In Synthesis of Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Bertrand, Didier et al. published their research in Bull. soc. chim. in 1945 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C4H12Cl2N2

Visible fluorescence and chemical structure. III. Double-bond nitrogen compounds and amine hydrochlorides was written by Bertrand, Didier. And the article was included in Bull. soc. chim. in 1945.Electric Literature of C4H12Cl2N2 This article mentions the following:

The double-bond N gives a fluorescence spectrum radically different from those of the amines and anilines studied. The effect of HCl is frequently to alter the intensity but not the shape of the spectral curve of the base. Fluorescence spectra are given for pyridine, quinoline, isoquinoline, acridine, N-benzylidenebenzylamine, N-heptylidenebenzylamine, and the hydrochlorides of pyridine, quinoline, isoquinoline, acridine, N-benzylideneaniline, N-benzylidenebenzylamine, N-benzylidene-β-naphthylamine, β-naphthylamine, carbazole, piperazine, PhNHEt, PhNEt2, 2-phenylethylamine, tetrahydroquinoline, and tetrahydroisoquinoline. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Electric Literature of C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Lunn, George et al. published their research in Synthesis in 1985 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: Piperazine Dihydrochloride

General cleavage of nitrogen-nitrogen and nitrogen-oxygen bonds using nickel/aluminum alloy was written by Lunn, George;Sansone, Eric B.;Keefer, Larry K.. And the article was included in Synthesis in 1985.Recommanded Product: Piperazine Dihydrochloride This article mentions the following:

Addition of Ni-Al alloy to KOH solutions of compounds containing N-N or N-O bonds is a general and convenient means for reducing such compounds to the corresponding amines. The method was successfully applied to the reduction of nitrosamines, hydrazines, hydroxylamines, hydroxylamine ethers, triazenes, nitramines, N-oxides, tetrazenes, and nitroso, azo, and azoxy compounds In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Recommanded Product: Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Gu, Dan et al. published their research in Synthetic Metals in 2009 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

Triphenylamine-based pH chemosensor: Synthesis, crystal structure, photophysical properties and computational studies was written by Gu, Dan;Yang, Guochun;He, Yi;Qi, Bin;Wang, Guang;Su, Zhongmin. And the article was included in Synthetic Metals in 2009.Category: piperazines This article mentions the following:

A triphenylamine-containing pH chemosensor, N,N’-di[3-(diphenylamine)benzyl]-piperazine, was designed and synthesized with Ullmann reaction. The compound crystallize in the monoclinic space group P21/n: a = 9.8004(12) Å, b = 13.3321(17) Å, c = 12.9575(16) Å, β = 103.510(2)°, Z = 2 and ρ = 1.212 Mg/m3. The synthesized compound excited by UV light produce intensive emission and a quantum yield of 0.56 relative to quinine sulfate was achieved. The fluorescence intensity of synthesized compound in water/DMF (4:1, volume/volume) under excitation of 307 nm decreased with the decrease of pH, exptl. and computational studies further confirmed that the protonation of N-triphenylamine leads to the fluorescence quenching. The results clearly indicate the potential of synthesized compound as highly efficient on-off switcher for protons. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Category: piperazines).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Langenbeck, Wolfgang et al. published their research in Journal fuer Praktische Chemie (Leipzig) in 1964 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Synthetic Route of C4H12Cl2N2

Reduction of 2,5-dioxopiperazines with lithium aluminum hydride was written by Langenbeck, Wolfgang;Augustin, Manfred;Boehm, Ralf;Hoffmann, Siegfried. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1964.Synthetic Route of C4H12Cl2N2 This article mentions the following:

2,5-Di-oxopiperazines added to excess LiAlH4 in dry tetrahydrofuran, the mixture refluxed 165 hrs., the excess LiAlH4 decomposed with dilute H2SO4, the solution extracted with Et2O, the raffinate alkalinized with KOH and steam-distilled, the distillate acidified with HCl and evaporated, and the residue crystallized from EtOH or EtOH-Et2O gave the piperazine hydrochlorides (substituents and % yield given): none, 40; 1,4-dimethyl, 62; 1,4-dibenzyl (free base m. 92掳), 57; 3,6-dimethyl, 55; 3,6-dimethyl, 38; 3,6-diisopropyl, 38; and 3,6-diisobutyl, 48 (250 hrs. reflux). In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Synthetic Route of C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Synthetic Route of C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cabani, S. et al. published their research in Journal of Physical Chemistry in 1977 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application In Synthesis of Piperazine Dihydrochloride

Volume changes in the proton ionization of amines in water. 1. Morpholines and piperazines was written by Cabani, S.;Mollica, V.;Lepori, L.;Lobo, S. T.. And the article was included in Journal of Physical Chemistry in 1977.Application In Synthesis of Piperazine Dihydrochloride This article mentions the following:

Apparent molar volumes, 桅v, at various concentrations in water at 25掳 of some cyclic bifunctional amines [morpholine, 4-methylmorpholine, piperazine, 1-methyl- and 1,4-dimethylpiperazine, 1,4-diazabicyclo[2.2.2]octane (triethylenediamine)] and their mono- and dihydrochlorides were determined The volume changes 螖V1掳 and 螖V2掳, involved in the 1st and 2nd proton ionizations from the protonated amines, were calculated from the limiting partial molar volumes V虆2掳. The volumes of ionization for the bifunctional cyclic amines were compared with those for the monofunctional amines ad the relationship between entropies and volumes of ionization was examined In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Application In Synthesis of Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application In Synthesis of Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

He, Yi et al. published their research in Fenzi Kexue Xuebao in 2011 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Formula: C4H12Cl2N2

The synthesis of piperazine-containing carbazole derivate and its sensing performance to proton was written by He, Yi;Li, Yan-mei. And the article was included in Fenzi Kexue Xuebao in 2011.Formula: C4H12Cl2N2 This article mentions the following:

A novel piperazine-containing carbazole derivative, N,N’-di[3-(N-carbazole)benzyl]-piperazine (DC-Pip) I, was designed and prepared The absorption and fluorescence maxima of DC-Pip were observed at 300 and 405 nm, resp. DC-Pip emits strong blue fluorescence and has a high quantum yield (桅F = 0.94) in solution, which indicates that DC-Pip can be used as fluorescence emitting materials. The effect of pH on the fluorescence characteristics of DC-Pip in H2O/DMF (4:1, V/V) solution has also been investigated, the intensity of fluorescence decreases with the decrease of pH value, these results shows that DC-Pip offers potential as optical sensor for protons. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Formula: C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Formula: C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Altaif, K. I. et al. published their research in American Journal of Veterinary Research in 1972 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Formula: C4H12Cl2N2

Comparative evaluation of efficacies of dl-tetramisole and piperazine against Ascaridia galli in chickens was written by Altaif, K. I.. And the article was included in American Journal of Veterinary Research in 1972.Formula: C4H12Cl2N2 This article mentions the following:

Dl-tetramisole (I) [5036-02-2] (20 and 40 mg/kg) administered in drinking water proved 87.7 and 99.0% efficacious, resp., against mature Ascaridia galli in chickens, whereas 20 mg/kg I mixed with feed gave a 63.0% reduction of the fecal egg count. Piperazine-2HCl [142-64-3] (260 mg/kg) given in drinking water resulted in a 96.4% reduction in fecal egg count whereas when given in the feed a 79.0% reduction was observed In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Formula: C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Formula: C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Verma, Sanjeev K. et al. published their research in Synthetic Communications in 2014 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Safety of Piperazine Dihydrochloride

Arylation of Amines and Monoarylation of Symmetrical Diamines in the Presence of Brine Solution with Diheteroaryl Halides was written by Verma, Sanjeev K.;Ghorpade, Ramarao;Kaushik, M. P.. And the article was included in Synthetic Communications in 2014.Safety of Piperazine Dihydrochloride This article mentions the following:

A simple, scalable, ligand-free, and metal-free protocol for arylation of amines and monoarylation of sym. diamines with diheteroaryl halides in the presence of brine solution has been developed. The protocol has broad structural applicability for chemoselective monoarylation of a wide variety of sym., cyclic, and acyclic aliphatic diamines. The protocol is also applicable for selective arylation of aliphatic amine in the presence of aromatic amine. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Safety of Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Safety of Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

He, Yi et al. published their research in Fenzi Kexue Xuebao in 2011 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Formula: C4H12Cl2N2

The synthesis of piperazine-containing carbazole derivate and its sensing performance to proton was written by He, Yi;Li, Yan-mei. And the article was included in Fenzi Kexue Xuebao in 2011.Formula: C4H12Cl2N2 This article mentions the following:

A novel piperazine-containing carbazole derivative, N,N’-di[3-(N-carbazole)benzyl]-piperazine (DC-Pip) I, was designed and prepared The absorption and fluorescence maxima of DC-Pip were observed at 300 and 405 nm, resp. DC-Pip emits strong blue fluorescence and has a high quantum yield (ΦF = 0.94) in solution, which indicates that DC-Pip can be used as fluorescence emitting materials. The effect of pH on the fluorescence characteristics of DC-Pip in H2O/DMF (4:1, V/V) solution has also been investigated, the intensity of fluorescence decreases with the decrease of pH value, these results shows that DC-Pip offers potential as optical sensor for protons. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Formula: C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Formula: C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics