20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A suspension of 1-fluoro-4-nitrobenzene (1.096 g, 7.77mmol), 1-cyclopropylpiperazine (1.00 g, 7.92 mmol) andpotassium carbonate (1.61 g, 11.65 mmol) in anhydrous DMF(10 mL) was heated to 50 C under a nitrogen atmosphereovernight. The reaction mixture was allowed to cool toroom temperature and poured into ice-water (50 mL) . Theprecipitated solid was isolated by filtration, washed with water and sucked dry to give the title compound as a yellow solid (1.11 g, 58%) . ?H NMR (500 MHz, CDC13) : 3 8.12 (d, 2H), 7.01 (d, 2H), 3.47 (t, 4H), 2.80 (t, 4H),1.70-1.80 (m, 1H), 0.45-0.60 (m, 4H) . LCMS (Method C):= 0.51 mi m/z = 248 [M+H].
20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics