204.2682 | Heterocyclic Building Blocks-piperazine

Li, Zhong’an et al. published their research in Advanced Materials (Weinheim, Germany) in 2016 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Synthetic Route of C12H16N2O

Highly Sensitive Built-In Strain Sensors for Polymer Composites: Fluorescence Turn-On Response through Mechanochemical Activation was written by Li, Zhong’an;Toivola, Ryan;Ding, Feizhi;Yang, Jeffrey;Lai, Po-Ni;Howie, Tucker;Georgeson, Gary;Jang, Sei-Hum;Li, Xiaosong;Flinn, Brian D.;Jen, Alex K.-Y.. And the article was included in Advanced Materials (Weinheim, Germany) in 2016.Synthetic Route of C12H16N2O This article mentions the following:

In this paper, the authors report the development of a new class of mechanochromic mols., that can be covalently linked to an epoxy thermoset network as built-in fluorescent strain sensors through simple and facile chem. Under mech. deformation, the sensing mols. in the epoxy matrix undergo a force-induced elimination reaction to regenerate the conjugated pathway between the donor and the acceptor forming a dipolar structure with strong intramol. charge-transfer. This sensor system can be activated even at a very low deformation strain about 0.14 accompanied with a fluorescence “turn-on” response, and is stable under prolonged exposure to light, demonstrating the significant value for practical applications of strain/damage sensing. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Synthetic Route of C12H16N2O).

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Schaller, Eva et al. published their research in International Journal of Molecular Sciences in 2021 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Quality Control of 4-(4-Methylpiperazin-1-yl)benzaldehyde

New 3-aryl-2-(2-thienyl)acrylonitriles with high activity against hepatoma cells was written by Schaller, Eva;Ma, Andi;Gosch, Lisa Chiara;Klefenz, Adrian;Schaller, David;Goehringer, Nils;Kaps, Leonard;Schuppan, Detlef;Volkamer, Andrea;Schobert, Rainer;Biersack, Bernhard;Nitzsche, Bianca;Hoepfner, Michael. And the article was included in International Journal of Molecular Sciences in 2021.Quality Control of 4-(4-Methylpiperazin-1-yl)benzaldehyde This article mentions the following:

New 2-(thien-2-yl)-acrylonitriles with putative kinase inhibitory activity were prepared and tested for their antineoplastic efficacy in hepatoma models. Four out of the 14 derivatives were shown to inhibit hepatoma cell proliferation at (sub-)micromolar concentrations with IC₅₀ values below that of the clin. relevant multikinase inhibitor sorafenib, which served as a reference Colony formation assays as well as primary in vivo examinations of hepatoma tumors grown on the chorioallantoic membrane of fertilized chicken eggs (CAM assay) confirmed the excellent antineoplastic efficacy of the new derivatives Their mode of action included an induction of apoptotic capsase-3 activity, while no contribution of unspecific cytotoxic effects was observed in LDH-release measurements. Kinase profiling of cancer relevant protein kinases identified the two 3-aryl-2-(thien-2-yl)acrylonitrile derivatives 1b and 1c as (multi-)kinase inhibitors with a preferential activity against the VEGFR-2 tyrosine kinase. Addnl. bioinformatic anal. of the VEGFR-2 binding modes by docking and mol. dynamics calculations supported the exptl. findings and indicated that the hydroxy group of 1c might be crucial for its distinct inhibitory potency against VEGFR-2. Forthcoming studies will further unveil the underlying mode of action of the promising new derivatives as well as their suitability as an urgently needed novel approach in HCC treatment. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Quality Control of 4-(4-Methylpiperazin-1-yl)benzaldehyde).

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wang, Ming-Qi et al. published their research in Bioorganic & Medicinal Chemistry in 2019 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C12H16N2O

Tuning the selectivity of N-alkylated styrylquinolinium dyes for sensing of G-quadruplex DNA was written by Wang, Ming-Qi;Xu, Jing;Zhang, Lan;Liao, Yue;Wei, Heng;Yin, Ying-Ying;Liu, Qiang;Zhang, Yuan. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Electric Literature of C12H16N2O This article mentions the following:

Selective and sensitive detection of G-quadruplex DNA structures is an important issue and attracts extensive interest. To this end, numerous small mol. fluorescent probes have been designed. Here, the authors present a series of N-alkylated styrylquinolinium dyes named Ls-1, Ls-2 and Ls-3 with varying side groups at the chain end. These dyes exhibited different binding behaviors to DNAs, and Ls-2 with a sulfonato group at the chain end displayed sensitivity and selectivity to G-quadruplex DNA structures in vitro. The characteristics of this dye and its interaction with G-quadruplex DNA were comprehensively studied by UV-visible spectrophotometry, fluorescence, CD and mol. docking. Furthermore, confocal fluorescence images and MTT assays indicated dye Ls-2 could pass through membrane and enter the living HepG2 cells with low cytotoxicity. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Electric Literature of C12H16N2O).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C12H16N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Liu, Wei et al. published their research in ChemistrySelect in 2022 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 27913-99-1

A Precise Molecular Design to Achieve ACQ-to-AIE Transformation for Developing New Mechanochromic Material by Regio-Isomerization Strategy was written by Liu, Wei;Wang, Xinli;Li, Renfu;Sun, Shitao;Li, Zhenli;Hao, Jinle;Lin, Bin;Jiang, Hong;Xie, Lijun. And the article was included in ChemistrySelect in 2022.Application of 27913-99-1 This article mentions the following:

Herein, we have designed and synthesized a series of MeO-rofecoxib based fluorophore (MORF1-6) for exploiting new promising mechanochromic luminescent (MCL) materials. Among them, MORF1 and MORF3 exhibit aggregation-induced emission (AIE) effects when the substituent is located at the ortho-position on the benzene ring of b. Meanwhile, by changing the type and position of the substituent, the corresponding compounds MORF2, MORF4, MORF5, MORF6 show aggregation caused-quenching (ACQ) behavior. These results demonstrate that the position and type of the substituent have a great effect on their fluorescent properties. Furthermore, an X-ray crystal structure anal. of MORF3 revealed that the intermol. π-π stacking was suppressed and intramol. hydrogen bonding were formed, which could effectively restrict the mol. motions, thus causing typical AIE effect and mechanochromic property. Finally, a re-writable data recording device was fabricated using MORF3 as the active material. Our mol. design strategy may provide a new avenue for achieving efficient MCL materials. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Application of 27913-99-1).

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Hassanein, Hassanein H. et al. published their research in Future Medicinal Chemistry in 2021 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.HPLC of Formula: 27913-99-1

Synthesis of new hexahydropyrimido[1,2-a]azepine derivatives bearing functionalized aryl and heterocyclic moieties as anti-inflammatory agents was written by Hassanein, Hassanein H.;Abdel Rahman, Doaa E.;Fouad, Marwa A.;Ahmed, Rehab F.. And the article was included in Future Medicinal Chemistry in 2021.HPLC of Formula: 27913-99-1 This article mentions the following:

New hexahydropyrimido[1,2-a]azepine derivatives bearing functionalized aryl and heterocyclic moieties were synthesized as anti-inflammatory agents with better safety profiles. All synthesized compounds were assessed in vitro for their COX-1 and COX-2 inhibition activities. The most selective compounds, 2f, 5 and 6, were further evaluated for their in vivo anti-inflammatory activity and PGE2 inhibitory activity. To rationalize their selectivity, mol. docking within COX-1 and COX-2 binding sites was performed. Their physicochem. properties and drug-like nature profile were also calculated The good activity and selectivity of compounds 2f, 5 and 6 were rationalized using a mol. docking study and supported by in vivo studies. These promising findings are encouraging for performing future investigations of these derivatives In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1HPLC of Formula: 27913-99-1).

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cibova, Alexandra et al. published their research in Chemical Papers in 2013 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.SDS of cas: 27913-99-1

Conjugated push-pull salts derived from linear benzobisthiazole: preparation and optical properties was written by Cibova, Alexandra;Magdolen, Peter;Fueloepova, Andrea;Zahradnik, Pavol. And the article was included in Chemical Papers in 2013.SDS of cas: 27913-99-1 This article mentions the following:

A series of novel monomethylated salts derived from linear benzobisthiazole was prepared The push-pull attributes of these new compounds are represented by a quaternized azolium cycle as the acceptor part at one end of the structure and the dialkylamino- or diarylamino-substituted benzene ring as the donor part at the opposite end. Both moieties are connected by a conjugated linker consisting of one or two double bonds. Such dipolar structures are promising candidates for non-linear optical materials. The quantum-chem. indexes describing linear and non-linear optical properties were obtained from semi-empirical calculations The relationships between the chem. structure and non-linear optical properties of the cations studied were obtained. Effective conjugation was confirmed by measuring the optical properties in the UV-VIS region. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1SDS of cas: 27913-99-1).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.SDS of cas: 27913-99-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Tawfik, Haytham O. et al. published their research in Pharmaceuticals in 2022 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Computed Properties of C12H16N2O

New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer was written by Tawfik, Haytham O.;El-Hamaky, Anwar A.;El-Bastawissy, Eman A.;Shcherbakov, Kirill A.;Veselovsky, Alexander V.;Gladilina, Yulia A.;Zhdanov, Dmitry D.;El-Hamamsy, Mervat H.. And the article was included in Pharmaceuticals in 2022.Computed Properties of C12H16N2O This article mentions the following:

Telomeres serve a critical function in cell replication and proliferation at every stage of the cell cycle. Telomerase is a ribonucleoprotein, responsible for maintaining the telomere length and chromosomal integrity of frequently dividing cells. Although it is silenced in most human somatic cells, telomere restoration occurs in cancer cells because of telomerase activation or alternative telomere lengthening. The telomerase enzyme is a universal anticancer target that is expressed in 85-95% of cancers. BIBR1532 is a selective non-nucleoside potent telomerase inhibitor that acts by direct noncompetitive inhibition. Relying on its structural features, three different series were designed, and 30 novel compounds were synthesized and biol. evaluated as telomerase inhibitors using a telomeric repeat amplification protocol (TRAP) assay. Target compounds 29a, 36b, and 39b reported the greatest inhibitory effect on telomerase enzyme with IC50 values of 1.7, 0.3, and 2.0 渭M, resp., while BIBR1532 displayed IC50 = 0.2 渭M. Compounds 29a, 36b, and 39b were subsequently tested using a living-cell TRAP assay and were able to penetrate the cell membrane and inhibit telomerase inside living cancer cells. Compound 36b was tested for cytotoxicity against 60 cancer cell lines using the NCI (USA) procedure, and the % growth was minimally impacted, indicating telomerase enzyme selectivity. To investigate the interaction of compound 36b with the telomerase allosteric binding site, mol. docking and mol. dynamics simulations were used. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Computed Properties of C12H16N2O).

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Burchacka, Ewa et al. published their research in Biochimie in 2014 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Product Details of 27913-99-1

Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro was written by Burchacka, Ewa;Sienczyk, Marcin;Frick, Inga-Maria;Wysocka, Magdalena;Lesner, Adam;Oleksyszyn, Jozef. And the article was included in Biochimie in 2014.Product Details of 27913-99-1 This article mentions the following:

SufA, which belongs to the subtilisin-like serine protease family, contains a non-canonical Asp-His-Ser catalytic triad. Under in vitro conditions, SufA is capable of human fibrinogen hydrolysis leading to inhibition of fibrin network formation, thus suggesting its important role in the development and progression of Finegoldia magna infections. In addition, it has been demonstrated that SufA can hydrolyze antibacterial peptides such as LL-37 and the chemokine MIG/CXCL 9, hence evading host defense mechanisms. Although the SufA protease from F. magna was discovered several years ago, its optimal substrate preference has not yet been identified. Considering the role of SufA, we have focused on the profiling of its substrate sequence preference spanning S1-S3 binding pockets using the FRET (fluorescence resonance energy transfer) approach. Next, based on the structure of the P1 residue of the developed substrate, we narrowed the inhibitor screening to the phosphonic analogs of amino acids containing an arginine-like side chain. Among all the compounds tested, only Cbz-6-AmNphth^P(OPh)₂ showed any inhibitory activity against SufA displaying k₂/K_i value of 10 800 M^-1 s^-1. In addition, it prevented SufA-mediated human fibrinogen hydrolysis in vitro and exhibited potent antibacterial activity against F. magna, Staphylococcus aureus and Escherichia coli.Herein, we report on the substrate specificity, synthesis and kinetic evaluation of phosphonic inhibitors of SufA protease from F. magna which could help to establish its function in pathogenesis development and may lead to the elaboration of new antibacterial drugs. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Product Details of 27913-99-1).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Product Details of 27913-99-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wang, Guangbao et al. published their research in Bioorganic Chemistry in 2021 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Safety of 4-(4-Methylpiperazin-1-yl)benzaldehyde

The discovery of novel sanjuanolide derivatives as chemotherapeutic agents targeting castration-resistant prostate cancer was written by Wang, Guangbao;Chen, Xiaojing;Wang, Nan;Xiao, Yunbei;Shu, Sheng;Alsayed, Ali Mohammed Mohammed;Liu, Lu;Ma, Yue;Liu, Peng;Zhang, Qianwen;Chen, Xiangjuan;Liu, Zhiguo;Zheng, Xiaohui. And the article was included in Bioorganic Chemistry in 2021.Safety of 4-(4-Methylpiperazin-1-yl)benzaldehyde This article mentions the following:

There remains a critical need for more effective therapies for the treatment of castration-resistant prostate cancer (CRPC), which is the leading cause of death in patients with prostate cancer. In this study, a series of sanjuanolide derivatives were designed, synthesized and evaluated as potential anti-CRPC agents. Most of the compounds had excellent selectivity for CRPC cells with IC50 values < 20渭M. Moreover, minimal side effects on human normal hepatic MIHA cells and normal prostatic stromal myofibroblast WPMY-1 cells were observed, with IC50 > 100渭M. The representative compound S07 slowed down the proliferative rate of CRPC cells, promoted cell apoptosis and caused G2/M phase accumulation, as well as G1/G0 phase reduction Further mechanistic studies showed that S07 treatment triggered intense DNA damage and provoked strong DNA damage response in a dose-dependent manner. These findings suggested that sanjuanolide derivatives, especially S07, selectively induced CRPC cell death by triggering intense DNA damage and DNA damage response. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Safety of 4-(4-Methylpiperazin-1-yl)benzaldehyde).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Safety of 4-(4-Methylpiperazin-1-yl)benzaldehyde

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Zhuang, Z.-P. et al. published their research in Journal of Medicinal Chemistry in 2001 | CAS: 27913-99-1

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Formula: C12H16N2O

Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates was written by Zhuang, Z.-P.;Kung, M.-P.;Hou, C.;Skovronsky, D. M.;Gur, T. L.;Ploessl, K.;Trojanowski, J. Q.;Lee, V. M.-Y.;Kung, H. F.. And the article was included in Journal of Medicinal Chemistry in 2001.Formula: C12H16N2O This article mentions the following:

We report for the first time that small mol.-based radioiodinated ligands, showing selective binding to A尾 aggregates, cross the intact blood-brain barrier by simple diffusion. Four novel ligands showing preferential labeling of amyloid aggregates of A尾(1-40) and A尾(1-42) peptides, commonly associated with plaques in the brain of people with Alzheimer’s disease (AD), were developed. Two ¹²⁵I-labeled styrylbenzenes, (E,E)-1-iodo-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene, I (ISB), and (E,E)-1-iodo-2,5-bis(3-hydroxycarbonyl-4-methoxy)styrylbenzene, II (IMSB), and two ¹²⁵I-labeled thioflavins, 2-[4′-(dimethylamino)phenyl]-6-iodobenzothiazole, III (TZDM), and 2-[4′-(4”-methylpiperazin-1-yl)phenyl]-6-iodobenzothiazole, IV (TZPI), were prepared at a high specific activity (2200 Ci/mmol). In vitro binding studies of these ligands showed excellent binding affinities with K_d values of 0.08, 0.13, 0.06, and 0.13 nM for aggregates of A尾(1-40) and 0.15, 0.73, 0.14, and 0.15 nM for aggregates of A尾(1-42), resp. Interestingly, under a competitive-binding assaying condition, different binding sites on A尾(1-40) and A尾(1-42) aggregates, which are mutually exclusive, were observed for styrylbenzenes and thioflavins. Autoradiog. studies of postmortem brain sections of a patient with Down’s syndrome known to contain primarily A尾(1-42) aggregates in the brain showed that both [¹²⁵I]-III and [¹²⁵I]-IV labeled these brain sections, but [¹²⁵I]-II, selective for A尾(1-40) aggregates, exhibited very low labeling of the comparable brain section. Biodistribution studies in normal mice after an iv injection showed that [¹²⁵I]-III and [¹²⁵I]-IV exhibited excellent brain uptake and retention, the levels of which were much higher than those of [¹²⁵I]-I and [¹²⁵I]-II. These findings strongly suggest that the new radioiodinated ligands may be useful as biomarkers for studying A尾(1-40) as well as A尾(1-42) aggregates of amyloidogenesis in AD patients. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Formula: C12H16N2O).

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics