Tag: 21043-40-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

(4-Cyclopentylpiperazin-1-yl)(5-nitro-3-phenyl-1H-indol-2-yl)methanone (13) The title compound was synthesized according to Representative Procedure A from 1-cyclopentylpiperazine (6.9 muL, 0.044 mmol, 1.2 equiv.), NMM (5 muL, 0.045 mmol, 1.2 equiv.) and 5-nitro-3-phenyl-1H-indole-2-carboxylic acid (10.4 mg, 0.046 mmol, 1.0 equiv.). Purification of the crude product by prep. TLC (10% MeOH/CH2Cl2 then 10% MeOH/EtOAc) provided the title compound as a yellow solid (8.9 mg, 57%): 1H NMR (400 MHz, CDCl3) delta 10.54 (s, 1H), 8.68 (d, J=2.2 Hz, 1H), 8.18 (dd, J=9.0, 2.2 Hz, 1H), 7.56-7.47 (m, 5H), 7.47-7.40 (m, 1H), 3.76 (s, 2H), 3.13 (s, 2H), 2.44 (s, 2H), 2.32 (p, J=8.1 Hz, 1H), 1.73 (d, J=17.9 Hz, 3H), 1.66-1.58 (m, 1H), 1.54-1.42 (m, 2H), 1.25 (s, 4H); HRMS (ESI-TOF+) m/z calc’d for C24H27N4O3 [M+H]+: 419.2078. found 419.2077.

21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The Scripps Research Institute; Cravatt, Benjamin F.; Niphakis, Micah J.; Lum, Kenneth; Correia, Bruno; Cognetta, Armand; Hulce, Jonathan; (156 pag.)US10168342; (2019); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

300 mg (0.86 mmol) der Verbindung aus Beispiel XVI werden in 8 ml 2-Ethyl-1- hexanol suspendiert und mit 266 mg (1.73 mmol) 1-Cyclopentylpiperazin und 0.75 ml (4.31 mmol) N, N-Diisopropylethylamin versetzt. Es wird ueber Nacht bei [150C] geruehrt. Nach dem Abkuehlen wird die Reaktionsloesung ueber eine MPLC gereinigt (Laufmittel : Dichlormethan-Methanol 10 : 1 + [1%] konzentrierter Ammo- niakloesung). Es werden 216 mg (52 % d. Th. ) Produkt erhalten. ‘H-NMR (400 MHz, DMSO-d6) : [8] [=] 1.28-1. 41 (m, 2H), 1.44-1. 55 (m, 2H), 1.57- 1.68 (m, 2H), 1.70-1. 85 (m, 2H), 2.43 (br. s, [5H),] 3.41 (br. s, 4H), 5.39 (s, 1H), 6.04 br. s, 2H), 6.97 (d, [2H),] 7.36 (dd, 1H), 7.45 (t, 1H), 8.23 (dd, 1H), 8.34 (d, 2H), 9.28 (s, [1H)] LC-MS (Methode 7) : [RT =] 2. [38] min MS (ESIpos) : [M/Z =] 466 [(M+H) +], 21043-40-3

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; WO2003/106450; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics