With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25057-77-6,1,2-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
To a stirred solution of (S)-l, 2-dimethylpiperazine (45g, 190.6mmol, leq) in EtOH (450mL) was added TEA (106.9mL, 762.7mmol, 4eq) under argon for 20min., then followed by addition of l-bromo-2,4-difluoro-5-nitrobenzene (47.8g, 286.0mmol, 1.5eq) at RT under argon atm and heated to 85C for 16h. TLC analysis indicated formation of less polar spot, then the reaction mixture was cooled to RT and solvent was evaporated under reduced pressure to give crude product, which was purified by column chromatography (silica gel, 100-200 mesh) using 0-30% EtOAc in pet ether as an eluent to afford (S)-4-(4-bromo-5-fluoro-2-nitrophenyl)-l,2- dimethylpiperazine (42g, 92%) as a yellow solid. LCMS: [M+H]+ 332.0.
25057-77-6, As the paragraph descriping shows that 25057-77-6 is playing an increasingly important role.
Reference£º
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ZEPEDA-VELAZQUEZ, Carlos Armando; PODA, Gennady; ISAAC, Methvin; UEHLING, David; WILSON, Brian; JOSEPH, Babu; LIU, Yong; SUBRAMANIAN, Pandiaraju; MAMAI, Ahmed; PRAKESCH, Michael; STILLE, Julia Kathleen; (1053 pag.)WO2017/147700; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics