Tag: 300-400

Biosynthesis of zinc oxide nanoparticles via endophyte Trichodermaviride and evaluation of their antimicrobial and antioxidant properties was written by Kaur, Tanvir;Bala, Manju;Kumar, Gaurav;Vyas, Ashish. And the article was included in Archives of Microbiology in 2022.COA of Formula: C16H18FN3O3 The following contents are mentioned in the article:

The biogenic method for synthesis of nanoparticles is preferred over the traditional strategies, on account of its ease, environmental friendliness, and cost-effectivity, wherein fungi endorse themselves to be the most appropriate precursor for the same. In recent times numerous metal nanoparticles have been reported to exhibit significant therapeutic activities, out of which Zinc Oxide nanoparticles (ZnO NPs) stand apart on account of their multidimensional nature. Thus, this study was carried out with an aim to biosynthesize ZnO NPs utilizing endophyte Trichoderma viride, isolated from the seeds of Momordica charantia. The physicochem. characterization of NPs was done via employing a combination of spectroscopic and microscopic techniques. The NPs were found to have a hexagonal shape and possessed an average particle size of around 63.3 nm. The antimicrobial activity of NPs was evaluated against multi-drug resistant organisms and it was observed to be an appreciable one whereas the antioxidant activity was deduced to be dose-dependent. Thus, these ZnO NPs can be considered as a probable active ingredient of any future therapeutic conceptualization after undertaking a thorough toxicol. assessment. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7COA of Formula: C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. COA of Formula: C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for specific recognition and determination of chloramphenicol in milk was written by Geng, Lingjun;Huang, Jingcheng;Zhai, Hongguo;Shen, Zheng;Han, Jie;Yu, Yanyang;Fang, Honggang;Li, Falan;Sun, Xia;Guo, Yemin. And the article was included in Microchemical Journal in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

A molecularly imprinted electrochem. sensor of chloramphenicol (CAP) with high sensitivity and good selectivity is introduced in this paper. Glassy carbon electrode (GCE) was modified by chitosan-multiwalled carbon nanotubes (CS-MWCNTs), the CS could improve the dispersion of MWCNTS, and the MWCNTS could significantly improve the current response of the sensor, thus improving the sensitivity. CAP was used as a template mol. and o-phenylenediamine (o-PD) was used as a functional monomer, resp. Molecularly imprinted polymers (MIPs) were prepared on the surface of a GCE modified with CS-MWCNTs by electro-polymerization The MIPs provided specific recognition sites for the detection of chloramphenicol. The exptl. parameters such as polymerization cycle, concentration ratio of template mol. to functional monomer, supporting electrolyte pH and incubation time were optimized. Under optimized exptl. conditions, the sensor has a linear range of 0.1-1000 ng/mL and the limit of detection (LOD) of 3.3 x 10-2 ng/mL (S/N = 3). The sensor had high selectivity, good stability and reproducibility for the detection of CAP, and it has been successfully used for the determination of CAP in real spiked milk samples. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Source, occurrence and risks of twenty antibiotics in vegetables and soils from facility agriculture through fixed-point monitoring and numerical simulation was written by Yu, Xiaolu;Zhang, Xinyu;Chen, Junhao;Li, Yang;Liu, Xiaoxia;Feng, Yang;Sun, Ying. And the article was included in Journal of Environmental Management in 2022.Formula: C16H18FN3O3 The following contents are mentioned in the article:

In this study, a universal method that combined fixed-point monitoring and numerical simulation was used to understand the source, fate and risks of antibiotics in environment. Results showed that the antibiotic concentration in vegetables, soil and manure from 53 fixed-point monitoring sampling sites were ND-18.47, ND-1438.50 and ND-24710.00¦Ìg kg^-1, resp. There were pos. correlations between the antibiotic concentrations of vegetables and soil as well as between soil and manure. The average Amountsoil/manure values were 1.48-46.02, indicating that antibiotics built up pseudo persistent residues in soil due to repeated fertilization. The modified level-III fugacity model showed that tetracyclines and fluoroquinolones tend to remain in soil given their sorption and mobility, while sulfonamides were highly distributed in plants, especially in leaves. Norfloxacin, ofloxacin, sulfadiazine, sulfamethoxazole and sulfisoxazole were found to be risk factors in facility agriculture and should be continuously monitored during agricultural production Most importantly, we used the inversion method to determine the recommended maximum residue limits of antibiotics in soil. This will not only allow for better control of the amount of the antibiotics in the environment, but also act as a potential method to assess the risks of pollutants without maximum residue limits in the environment. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Formula: C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Formula: C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Emergence of plasmid-mediated tigecycline, ¦Â-lactam and florfenicol resistance genes tet(X), bla_OXA-347 and floR in Riemerella anatipestifer isolated in China was written by Zhu, Dekang;Wei, Xinyi;Zhu, Hong;Yang, Zhishuang;Wang, Mingshu;Jia, Renyong;Chen, Shun;Liu, Mafeng;Zhao, Xinxin;Yang, Qiao;Wu, Ying;Zhang, Shaqiu;Huang, Juan;Ou, Xumin;Mao, Sai;Gao, Qun;Sun, Di;Tian, Bin;Cheng, Anchun. And the article was included in Poultry Science in 2022.COA of Formula: C16H18FN3O3 The following contents are mentioned in the article:

Bacterial antimicrobial resistance (AMR) continues to develop, with the horizontal transfer of antibiotic resistance genes (ARGs) through plasmids playing a major role. Recently, the antimicrobial resistance of R. anatipestifer has become increasingly severe, jeopardizing the development of the poultry industry. In this study, we used PromethION to determine the whole genome sequence of R. anatipestifer RCAD0416, a multidrug-resistant isolate from China. We detected a plasmid in the isolate. We named the plasmid pRCAD0416RA-1; the plasmid was 37356 bp in size with 36 putative open reading frames and included the blaOXA-347, floR, tet(X), ermF, ereD, and AadS resistance genes. Most resistance genes might be obtained from R. anatipestifer HXb2. Mobile elements and floR might be transmitted by plasmid pB18-2 from Acinetobacter indicus, and the ICEPg6Chn1 mobile elements can be transmitted from Proteus genomosp. The plasmid pRCAD0416RA-1 was transferred to Escherichia coli K-12 x 7232 via electroporation. Subsequent antimicrobial sensitivity tests (AST) showed a noticeable levels of antimicrobial resistance to ¦Â-lactams (4-8 fold), tigecycline (8 fold), and florfenicol (8 fold). These types of antibiotics are in common clin. use. The purpose of this article is to elucidate the basic characteristics of pRCAD0416RA-1 and the level of resistance mediated by blaOXA-347, floR, and tet(X). This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7COA of Formula: C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).COA of Formula: C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Source, occurrence and risks of twenty antibiotics in vegetables and soils from facility agriculture through fixed-point monitoring and numerical simulation was written by Yu, Xiaolu;Zhang, Xinyu;Chen, Junhao;Li, Yang;Liu, Xiaoxia;Feng, Yang;Sun, Ying. And the article was included in Journal of Environmental Management in 2022.Formula: C16H18FN3O3 The following contents are mentioned in the article:

In this study, a universal method that combined fixed-point monitoring and numerical simulation was used to understand the source, fate and risks of antibiotics in environment. Results showed that the antibiotic concentration in vegetables, soil and manure from 53 fixed-point monitoring sampling sites were ND-18.47, ND-1438.50 and ND-24710.00¦Ìg kg^-1, resp. There were pos. correlations between the antibiotic concentrations of vegetables and soil as well as between soil and manure. The average Amountsoil/manure values were 1.48-46.02, indicating that antibiotics built up pseudo persistent residues in soil due to repeated fertilization. The modified level-III fugacity model showed that tetracyclines and fluoroquinolones tend to remain in soil given their sorption and mobility, while sulfonamides were highly distributed in plants, especially in leaves. Norfloxacin, ofloxacin, sulfadiazine, sulfamethoxazole and sulfisoxazole were found to be risk factors in facility agriculture and should be continuously monitored during agricultural production Most importantly, we used the inversion method to determine the recommended maximum residue limits of antibiotics in soil. This will not only allow for better control of the amount of the antibiotics in the environment, but also act as a potential method to assess the risks of pollutants without maximum residue limits in the environment. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Formula: C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Formula: C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Emergence of plasmid-mediated tigecycline, ¦Â-lactam and florfenicol resistance genes tet(X), bla_OXA-347 and floR in Riemerella anatipestifer isolated in China was written by Zhu, Dekang;Wei, Xinyi;Zhu, Hong;Yang, Zhishuang;Wang, Mingshu;Jia, Renyong;Chen, Shun;Liu, Mafeng;Zhao, Xinxin;Yang, Qiao;Wu, Ying;Zhang, Shaqiu;Huang, Juan;Ou, Xumin;Mao, Sai;Gao, Qun;Sun, Di;Tian, Bin;Cheng, Anchun. And the article was included in Poultry Science in 2022.COA of Formula: C16H18FN3O3 The following contents are mentioned in the article:

Bacterial antimicrobial resistance (AMR) continues to develop, with the horizontal transfer of antibiotic resistance genes (ARGs) through plasmids playing a major role. Recently, the antimicrobial resistance of R. anatipestifer has become increasingly severe, jeopardizing the development of the poultry industry. In this study, we used PromethION to determine the whole genome sequence of R. anatipestifer RCAD0416, a multidrug-resistant isolate from China. We detected a plasmid in the isolate. We named the plasmid pRCAD0416RA-1; the plasmid was 37356 bp in size with 36 putative open reading frames and included the blaOXA-347, floR, tet(X), ermF, ereD, and AadS resistance genes. Most resistance genes might be obtained from R. anatipestifer HXb2. Mobile elements and floR might be transmitted by plasmid pB18-2 from Acinetobacter indicus, and the ICEPg6Chn1 mobile elements can be transmitted from Proteus genomosp. The plasmid pRCAD0416RA-1 was transferred to Escherichia coli K-12 x 7232 via electroporation. Subsequent antimicrobial sensitivity tests (AST) showed a noticeable levels of antimicrobial resistance to ¦Â-lactams (4-8 fold), tigecycline (8 fold), and florfenicol (8 fold). These types of antibiotics are in common clin. use. The purpose of this article is to elucidate the basic characteristics of pRCAD0416RA-1 and the level of resistance mediated by blaOXA-347, floR, and tet(X). This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7COA of Formula: C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).COA of Formula: C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Multidrug-resistant and potentially pathogenic Enterobacteriaceae found in a tertiary hospital sewage in southeastern Brazil was written by Nakamura-Silva, Rafael;Dias, Leila Lucia;Sousa, Ricardo Coelho;Fujimoto, Rodrigo Yudi;Pitondo-Silva, Andre. And the article was included in Environmental Monitoring and Assessment in 2022.Category: piperazines The following contents are mentioned in the article:

Hospital sewage is considered an environment with the potential to favor the spread and increase of multidrug-resistant bacteria (MDR). The increase in antimicrobial resistance is one of the greatest global threats today. Therefore, this study aimed to evaluate the profile of antimicrobial susceptibility and virulence factors in Enterobacteriaceae isolated from the sewage of a tertiary hospital located in southeastern Brazil. For bacterial isolation, membrane filtering, serial dilution, and spread-plate techniques were used. The bacterial isolates were identified using the MALDI-TOF (matrix-assisted laser desorption ionization-time of flight) technique. Antimicrobial susceptibility profile was performed by disk-diffusion test. Virulence genes were screened by Polymerase Chain Reaction (PCR) and the hypermucoviscosity phenotype by string test. In total, 13 enterobacteria distributed in three species were identified (Klebsiella pneumoniae, Escherichia coli, and Citrobacter freundii) and 76.9% (n = 10) were classified as MDR. Two K. pneumoniae demonstrated the hypermucoviscosity phenotype. The virulence genes ycfM and entB were detected in all K. pneumoniae isolates (other genes found were fimH, mrkD, and kfu). The results indicated that the sewage from the analyzed hospital receives MDR bacteria and has the potential to contaminate and spread through the environment. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Category: piperazines).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Tetracycline sensitizes TiO₂ for visible light photocatalytic degradation via ligand-to-metal charge transfer was written by Qin, Caidie;Tang, Juanjuan;Qiao, Ruxia;Lin, Sijie. And the article was included in Chinese Chemical Letters in 2022.Product Details of 70458-96-7 The following contents are mentioned in the article:

Treatment of antibiotics contaminated water remains a global environmental challenge. In this study, tetracycline (TC) was found to effectively sensitize pure TiO₂ for visible light photocatalytic degradation via a ligand-to-metal charge transfer mechanism. The sensitization was attributed to the formation of TC-TiO₂ complex and the overlap of the MOs of TC and the conduction band of TiO₂. The intermediate degradation products of TC, however, did not sensitize TiO₂, which was the reason for the low mineralization rate. Nevertheless, our results showed that the intermediate degradation products of TC had significantly reduced bactericidal effects and less induction of antibiotic-resistance genes (ARGs). This study showcases an effective treatment of antibiotics-containing wastewater using the most common photocatalyst TiO₂ with reduced risk in the spread of ARGs. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Product Details of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Product Details of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Two Cd(II)-based metal-organic frameworks as difunctional fluorescence sensors to detect enrofloxacin and Fe³⁺ was written by Wen, Ming-Yue;Fu, Lianshe;Dong, Gui-Ying. And the article was included in Journal of Solid State Chemistry in 2022.Computed Properties of C16H18FN3O3 The following contents are mentioned in the article:

Two ternary Cd(II) metal-organic frameworks [Cd₄(L)₂(2,6-NDA)₄·5H₂O]_n (1) and [Cd(L)_0.5(1,8-NDA)·0.75H₂O]_n (2) (L = 1,4-bis(1-(piperidin-4-ylmethyl)-1H-benzo[d]imidazole-2-yl)butane, 2,6-H₂NDA = 2,6-naphthalenedicarboxylic acid, 1,8-H₂NDA = 1,8-naphthalenedicarboxylic acid) were synthesized based on the L and two isomeric naphthalene dicarboxylic acids. 1 And 2 exhibit a 3D 4,4T11 and a 2D 3,4L13 network, resp. Both 1 and 2 show remarkable thermal stability and can be used as difunctional fluorescence sensors for Fe³⁺ and enrofloxacin via a fluorescence quenching process with high sensitivity and selectivity. In addition, the fluorescence sensing mechanism was discussed in detail. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Computed Properties of C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Computed Properties of C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification was written by Komoriya, Satoshi;Kobayashi, Shozo;Osanai, Ken;Yoshino, Toshiharu;Nagata, Tsutomu;Haginoya, Noriyasu;Nakamoto, Yumi;Mochizuki, Akiyoshi;Nagahara, Takayasu;Suzuki, Makoto;Shimada, Takashi;Watanabe, Kengo;Isobe, Yumiko;Furugoori, Taketoshi. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Category: piperazines The following contents are mentioned in the article:

Serine protease factor Xa (fXa) inhibitor I showed good ex vivo anti-fXa activity upon oral administration in rats. However, it has been revealed that I had low metabolic stability against human liver microsomes. To improve the metabolic stability, we attempted to modify the S1 and S4 ligands of I. These modifications resulted in a compound which exhibited selective anti-fXa activity and excellent anti-coagulation activity. This study involved multiple reactions and reactants, such as Methyl 2-(1,4-dibenzylpiperazin-2-yl)acetate (cas: 183742-32-7Category: piperazines).

Methyl 2-(1,4-dibenzylpiperazin-2-yl)acetate (cas: 183742-32-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics