Tag: 30459-17-7

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 0.332/0.36885 g (0.001 mol) of 1-(6-bromohexyl)-1,8-naphthosultam(3a)/lactam (3b), 0.00095 mol of the corresponding arylpiperazine(4), 0.414/0.120 g (0.003 mol) K2CO3/NaOH and 0.032 g(0.0001 mol) of TBAB were triturated in a mortar. The triturated mixturewas transferred to a round bottom flask. In the case of the reactionin the presence of the solvent, 0.2 cm3 of acetonitrile, DMF or water wasadded to the reaction mixture. The reactions were carried out for 50 s ina CEM Discover microwave reactor at a 100W output power. Theprogress of the reaction was monitored by TLC (CHCl3:MeOH 9:1).After completion of the reaction, 40 cm3 of water was added to themixture and placed in the refrigerator overnight. After cooling, thecrude product was filtered off. In the absence of the required purity, thecrude product was crystallized from methanol or methanol-water. Afterobtaining a minimum of 90% purity, the ligands were dissolved inacetone, then converted to 4M HCl hydrochloride in dioxane. The reactionyields for individual ligands were calculated based on the weightof the obtained pure hydrochloride.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zar?ba, Przemys?aw; Ja?kowska, Jolanta; Czekaj, Izabela; Sata?a, Grzegorz; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3396 – 3407;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the chloro compounds (1.00 mmol) in toluene, were added piperazines 8a-j (1.0 mmol) at room temperature. The reaction mixture was heated at 110 oC for overnight. After completion (TLC), the reaction mixture was extracted with ethyl acetate and water. The organic layer was separated and dried over anhydrous Na2SO4, evaporated to dryness. The residue was purified with column chromatography using an eluent of 25% ethyl acetate in hexane to furnish the compounds with moderate to good yields (64-82%)., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various.

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Article; Banu, Saleha; Bollu, Rajitha; Naseema, Mohammad; Gomedhika, P. Mary; Nagarapu, Lingaiah; Sirisha; Kumar, C. Ganesh; Gundasw, Shravan Kumar; Bioorganic and Medicinal Chemistry Letters; vol. 28; 7; (2018); p. 1166 – 1170;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: At first, THF (2.0 mL) was added to a mixture of oxabenzonorbornadiene 1 (0.347 mmol, 1.0 equiv), amine 4 or 6 (1.041 mmol, 3.0 equiv), NaI (10.34 mg, 0.069 mmol, 0.2 equiv), ligand L2 (4.5 mg, 0.0167 mmol, 4.8 mol %) and [Rh(C2H4)2Cl]2 (2.7 mg, 0.0069 mmol, 2.0 mol %) under N2. The mixture was then stirred at RT for 1 h and heated at reflux for 6-12 h after which the residue was subjected directly to silica gel column chromatography [ethylacetate/hexanes (1:1-2:1 v/v) as the eluent] to afford the desired alcohol product 5 or 7. The enantioselectivity was determined by chiral HPLC on a chiralcel OD-H, chiralcel AD-H, or Lux Amylose-2 column.

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Luo, Renshi; Xie, Ling; Liao, Jianhua; Xin, Hu; Chan, Albert S.C.; Tetrahedron Asymmetry; vol. 25; 9; (2014); p. 709 – 717;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 [0116] 0.61 g (1.29 mmol) of betulonic acid chloride was dissolved in 40 mL of anhydrous dichloromethane (CH2Cl2), and then 0.72 mL (5.16 mmol) of anhydrous triethylamine and 0.60 g (2.58 mmol) of 1-(4-trifluoromethylphenyl)piperazine were added thereto, and then stirred at 25 C. for 48 hours. The resulting product was washed with 10% HCl (40 mL¡Á3), further washed with pure water (40 mL¡Á3), and then a solvent layer was dried by 10 g of anhydrous Na2SO4. A dichloromethane (DCM) layer was evaporated and dried to obtain 0.85 g of light brown solids. These light brown solids were dissolved in ethanol to prepare a sample, and then this sample was fractionated by RP C18 semi-prep HPLC, and then completely evaporated and dried to obtain 0.64 g (yield: 74.9%) of 4-(4?-trifluoromethylphenylpiperazine-1-yl) amide betulonic acid. [0117] 1H NMR (600 MHz, CDCl3): [0118] A white crystalline solid, m.p. 229-230 C. IR (ATR) umax cm-1: 2944, 1704 (C?O), 1616 (CONH), 1525, 1458, 1332, 1230, 1112, 1073, 1023, 885, 830. 1H NMR (600 MHz, CDCl3): 0.93 (3H, s, Me-25), 0.96 (1H, m, H-12), 0.97 (3H, s, Me-27), 0.98 (3H, s, Me-26), 1.02 (3H, s, Me-24), 1.06 (3H, s, Me-23), 1.19 (1H, m, H-15), 1.30-1.52 (12H, m, H-1, 5, 6, 6, 7, 7, 9, 11, 11, 15, 16, 21), 1.59 (2H, m, H-12, 18), 1.69 (3H, s, Me-30), 1.75 (1H, m, H-22), 1.89 (2H, m, H-1, 21), 2.01 (1H, m, H-22), 2.16 (1H, m, H-16), 2.39 (1H, m, H-2), 2.49 (1H, m, H-2), 2.92 (1H, m, H-13), 3.00 (1H, dt, J1=11.4 Hz, J2=4.2 Hz, H-19), 3.41 (4H, m, H-3?, 3?, 5?, 5?), 3.78 (4H, m, H-2?, 2?, 6?, 6?), 4.74 and 4.60 (2H, both br. s, H-29), 6.94 (2H, d, J=8.4 Hz, H-2?, 6?), 7.51 (2H, d, J=8.4 Hz, H-3?, 5?). [0119] C41H59N2O2F3, 4-(4?-trifluoromethylphenylpiperazine-1-yl) amide betulonic acid 7, 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KOREA INSTITUTE OF ENERGY RESEARCH; Chue, Kuck-Tack; Kim, Tae-Hwan; Ten, Leonid; US2014/243527; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-bromo-3 ,5-dinitrobenzene (2.84g 11.50mmol), N-(trifluoromethylphenyl)piperazine (2.66g 11.50mmol), Xphos (0.493g 1.035mmol), palladium(II) acetate (0.077g 0.345mmol), potassiumcarbonate (2.225g16.1mmol) and tert-butanol (23ml) then stirred reaction mixture at 95C for 3 hours under nitrogen atmosphere. 1-(3,5-dinitrophenyl)-4-(4- (trifluoromethyl) phenyl)piperazine (2.87g 7.25mmol) Yield: 63% white solid obtained.

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; Taewon SISChem co.,Ltd; Choe, Sung Muk; Myung, Do; Sung, Gyung Hwan; Jang, Sung Hwa; (20 pag.)KR101589584; (2016); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of acid chloride 3a-b (1.0 equiv.), triethylamine (3.0 equiv.) in dry THF, was added arylpiperazines (1.2 equiv.) in dry THF dropwise. The mixture was stirred for 1 h at room temperature. The reaction mixture was diluted with EtOAc, washed with water and brine, dried over anhydrous MgSO4, and concentrated in vacuo. The crude product was purified by flash column chromatography on silica gel (EtOAC:hexanes = 1:1-1:5) to yield the desired products (4a-j). Compound 4i: 1H NMR (300 MHz, CDCl3) delta 7.52 (d, J = 8.5 Hz, 2H), 6.95 (d, J = 8.5 Hz, 2H), 3.95 (m, 4H), 3.37 (m, 4H), 2.79 (m, 4H), 1.80 (m, 4H).

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Song, Jiho; Lee, Kiho; Kim, Doran; Kim, Jongmin; Lee, Seul; Shin, Jun Seob; Kim, Dong-Seok; Min, Kyung Hoon; Bulletin of the Korean Chemical Society; vol. 35; 2; (2014); p. 666 – 668;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 119 Preparation of rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-yl]-1,3-dihydro-indol-2-one The mixture of rac-3-bromo-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one (100 mg, 0.270 mmol), 1-(4-trifluoromethyl-phenyl)-piperazine (75 mg, 0.324 mmol) and DIPEA (42 mg, 0.324 mmol) In acetonitrile (3 mL) was stirred at room temperature for overnight. The crude was concentrated and the residue was purified with preparative HPLC to give 76 mg of rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one as a white solid. MS: 520 (M+H)+. H1-NMR (400 MHz, CDCl3) delta 7.584 (s, 1H), 7.493 (d, 2H), 7.240 (d, 1H), 7.081 (t, 2H), 7.011 (t, 1H), 6.908 (d, 3H), 6.766 (d, 1H), 6.684 (d, 1H), 3.431 (d, 1H), 3.329-3.206 (m, 5H), 2.947 (t, 4H).

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chen, Li; Yang, Song; Zhang, Jing; Zhang, Zhuming; US2008/81810; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 3-(4-fluorophenylthio)propyl methanesulfonate (4b) (1.0 g, 3.79 mmol), 4-(4-chloro-phenyl)-piperidin-4-ol (0.8 g, 3.79 mmol), KI (120 mg), K2CO3 (1.2 g, 8.7 mmol) in DME (10 mL) was heated to reflux under N2 for 12 h. The cooled mixture was then diluted with EtOAc (400 mL) and washed with H2O (200 mL). The organic layers were pooled, dried with Na2SO4, and filtered. The filtrate was concentrated in vacuo, then followed by purification through column chromatography on silica gel, to afford 4-(4-chlorophenyl)-1-(3-((4-fluorophenyl)thio)propyl)piperidin-4-ol (6); yield 74%,

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Peprah, Kwakye; Zhu, Xue Y.; Eyunni, Suresh V.K.; Setola, Vincent; Roth, Bryan L.; Ablordeppey, Seth Y.; Bioorganic and Medicinal Chemistry; vol. 20; 3; (2012); p. 1291 – 1297;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics