381242-61-1, 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred mixture of 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate (1) (1.65 g, 0.005 mol), C2H5OH (30 mL) and N(C2H5)3 (3 mL), 1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine (2) (1.65 g, 0.006 mol) was added and heated at 70-80 C for 5 h. The reaction was monitored by TLC. After filtration, the filtrate was evaporated under reduced pressure. Water (30 mL) was added to the residue, which was then extracted with ethyl acetate (80 mL ¡Á 3). The extract was washed with saturated NaCl solution (20 mL ¡Á 3), dried over anhydrous Na2SO4 and evaporated. The residue was crystallized from C2H5OH to afford a white solid 3 1.92 g, in 75% yield: m.p. 115-117 C. 1H NMR (DMSO-d6): 6.80-8.48 (6H, m, Ar-H), 7.81, 8.13 (2H, ss, triazole-H), 4.51-4.60 (2H, dd, J = 15 Hz, triazole-CH2-), 2.50-3.01 (8H, m, piperazine-H), 2.73-3.17 (2H, dd, J = 15 Hz, CH2-piperazine-), 5.10 (1H, s, OH). IR (KBr): 3200, 2940, 2893, 1605, 1514, 1338, 1257, 1136, 918 cm-1. LC-MS, m/z Calcd. for C22H21F5N6O3, 512.2, found [M + H]+ 513.3., 381242-61-1
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Reference£º
Article; Chai, Xiaoyun; Zhang, Jun; Cao, Yongbing; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Sun, Qingyan; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 3167 – 3176;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics