Tag: 505.9499

Development of validated spectrofluorimetric method for the estimation of buclizine hydrochloride from the tablet dosage form was written by Suganthi, A.;Fathimunnisa, A.;Sumithra, S.;Ravi, T. K.. And the article was included in Indo American Journal of Pharmaceutical Research in 2016.Application of 129-74-8 This article mentions the following:

Buclizine hydrochloride from its tablet dosage form was estimated by developing a novel validated indirect spectrofluorimetric method. Here the Buclizine hydrochloride was derivatized into nitro compound using nitrating mixture with an aid of heat which showed good fluorescence in water at 446 nm after excited at 350 nm. The calibration graph showed linear over the range 200-1000 ng/mL. The assay of buclizine hydrochloride in marketed formulations was found to be 98.96 卤 0.1586. Recovery values were close to 100% with the % RSD values of 0.432% and 0.673% at 50% and 100% level resp. From the results of validation it was observed that the method was found to be simple, accurate, sensitive and reproducible. Hence the proposed method can be used for routine quality control anal. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Application of 129-74-8).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 129-74-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The relative bioavailability of paracetamol after rectal administration of suppositories containing a mixture of paracetamol, codeine phosphate and buclizine hydrochloride in healthy volunteers was written by Burgess, H. A.;Merrington, D. M.;Oliver, W. J.;Thomson, A.;Rogers, H. J.. And the article was included in Current Medical Research and Opinion in 1985.Reference of 129-74-8 This article mentions the following:

The bioavailability of paracetamol (I) [103-90-2] from suppositories containing I, codeine聽phosphate聽聽[52-28-8], and buclizine-HCl聽聽[129-74-8] was studied in healthy volunteers. No significant difference in bioavailability between suppositories stored 6 and 30 mo. was found. Mean peak plasma concentrations for 6 and 30 mo old suppositories were 4.75 mg/L and 4.6 mg/L, resp., mean elimination half-life was 4.4 h and 3.73 h, resp. and areas under the concentration-time curve were 2273 mg L^-1 min and 2338 mg L^-1 min, resp. These bioavailability data were similar to those obtained in a study where suppositories containing only I were used, indicating that the presence of codeine and buclizine in the suppository formulation did not affect the absorption of I. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Reference of 129-74-8).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 129-74-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors was written by Heinke, Ralf;Spannhoff, Astrid;Meier, Rene;Trojer, Patrick;Bauer, Ingo;Jung, Manfred;Sippl, Wolfgang. And the article was included in ChemMedChem in 2009.Reference of 129-74-8 This article mentions the following:

Lysine and arginine methyltransferases participate in the posttranslational modification of histones and regulate key cellular functions. Protein arginine methyltransferase 1 (PRMT1) has been identified as an essential component of mixed lineage leukemia (MLL) oncogenic complexes, revealing its potential as a novel therapeutic target in human cancer. The first potent arginine methyltransferase inhibitors were recently discovered by random- and target-based screening approaches. Herein we report virtual and biol. screening for novel inhibitors of PRMT1. Structure-based virtual screening (VS) of the Chembridge database composed of 328 000 mols. was performed with a combination of ligand- and target-based in silico approaches. Nine inhibitors were identified from the top-scored docking solutions; these were exptl. tested using human PRMT1 and an antibody-based assay with a time-resolved fluorescence readout. Among several aromatic amines, an aliphatic amine and an amide were also found to be active in the micromolar range. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Reference of 129-74-8).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 129-74-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Optimization of quantitative analysis of buclizine hydrochloride using UV spectrophotometry in bulk drug and dosage formulations was written by Siddiqui, Farhan Ahmed;Mirza, Agha Zeeshan;Zuberi, M. Hashim;Qureshi, Faiza. And the article was included in Medicinal Chemistry Research in 2011.Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride This article mentions the following:

Development and validation of an anal. spectral calibration method to quantify buclizine hydrochloride, which is a piperazine derivative and used as a single active principle in pharmaceutical forms were done. The quantification of buclizine hydrochloride was performed in the wavelength range of 218-226 nm at N = 6. The linear regression equation was constructed using relationship between concentration and absorbance at 218, 220, 222, 224, and 226 nm. The developed method was applied directly and easily to the anal. of the pharmaceutical tablet preparations Mean %RSD was found to be 0.6231% (Longifene tablet 25 mg). The method was completely validated and proven to be rugged. This validated UV spectrophotometric method is potentially useful for a routine laboratory anal. because of its simplicity, rapidity, sensitivity, precision, and accuracy. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors was written by Heinke, Ralf;Spannhoff, Astrid;Meier, Rene;Trojer, Patrick;Bauer, Ingo;Jung, Manfred;Sippl, Wolfgang. And the article was included in ChemMedChem in 2009.Reference of 129-74-8 This article mentions the following:

Lysine and arginine methyltransferases participate in the posttranslational modification of histones and regulate key cellular functions. Protein arginine methyltransferase 1 (PRMT1) has been identified as an essential component of mixed lineage leukemia (MLL) oncogenic complexes, revealing its potential as a novel therapeutic target in human cancer. The first potent arginine methyltransferase inhibitors were recently discovered by random- and target-based screening approaches. Herein we report virtual and biol. screening for novel inhibitors of PRMT1. Structure-based virtual screening (VS) of the Chembridge database composed of 328 000 mols. was performed with a combination of ligand- and target-based in silico approaches. Nine inhibitors were identified from the top-scored docking solutions; these were exptl. tested using human PRMT1 and an antibody-based assay with a time-resolved fluorescence readout. Among several aromatic amines, an aliphatic amine and an amide were also found to be active in the micromolar range. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Reference of 129-74-8).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 129-74-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Optimization of quantitative analysis of buclizine hydrochloride using UV spectrophotometry in bulk drug and dosage formulations was written by Siddiqui, Farhan Ahmed;Mirza, Agha Zeeshan;Zuberi, M. Hashim;Qureshi, Faiza. And the article was included in Medicinal Chemistry Research in 2011.Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride This article mentions the following:

Development and validation of an anal. spectral calibration method to quantify buclizine hydrochloride, which is a piperazine derivative and used as a single active principle in pharmaceutical forms were done. The quantification of buclizine hydrochloride was performed in the wavelength range of 218-226 nm at N = 6. The linear regression equation was constructed using relationship between concentration and absorbance at 218, 220, 222, 224, and 226 nm. The developed method was applied directly and easily to the anal. of the pharmaceutical tablet preparations Mean %RSD was found to be 0.6231% (Longifene tablet 25 mg). The method was completely validated and proven to be rugged. This validated UV spectrophotometric method is potentially useful for a routine laboratory anal. because of its simplicity, rapidity, sensitivity, precision, and accuracy. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Development of validated spectrofluorimetric method for the estimation of buclizine hydrochloride from the tablet dosage form was written by Suganthi, A.;Fathimunnisa, A.;Sumithra, S.;Ravi, T. K.. And the article was included in Indo American Journal of Pharmaceutical Research in 2016.Application of 129-74-8 This article mentions the following:

Buclizine hydrochloride from its tablet dosage form was estimated by developing a novel validated indirect spectrofluorimetric method. Here the Buclizine hydrochloride was derivatized into nitro compound using nitrating mixture with an aid of heat which showed good fluorescence in water at 446 nm after excited at 350 nm. The calibration graph showed linear over the range 200-1000 ng/mL. The assay of buclizine hydrochloride in marketed formulations was found to be 98.96 ± 0.1586. Recovery values were close to 100% with the % RSD values of 0.432% and 0.673% at 50% and 100% level resp. From the results of validation it was observed that the method was found to be simple, accurate, sensitive and reproducible. Hence the proposed method can be used for routine quality control anal. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Application of 129-74-8).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 129-74-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The relative bioavailability of paracetamol after rectal administration of suppositories containing a mixture of paracetamol, codeine phosphate and buclizine hydrochloride in healthy volunteers was written by Burgess, H. A.;Merrington, D. M.;Oliver, W. J.;Thomson, A.;Rogers, H. J.. And the article was included in Current Medical Research and Opinion in 1985.Reference of 129-74-8 This article mentions the following:

The bioavailability of paracetamol (I) [103-90-2] from suppositories containing I, codeine phosphate  [52-28-8], and buclizine-HCl  [129-74-8] was studied in healthy volunteers. No significant difference in bioavailability between suppositories stored 6 and 30 mo. was found. Mean peak plasma concentrations for 6 and 30 mo old suppositories were 4.75 mg/L and 4.6 mg/L, resp., mean elimination half-life was 4.4 h and 3.73 h, resp. and areas under the concentration-time curve were 2273 mg L^-1 min and 2338 mg L^-1 min, resp. These bioavailability data were similar to those obtained in a study where suppositories containing only I were used, indicating that the presence of codeine and buclizine in the suppository formulation did not affect the absorption of I. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Reference of 129-74-8).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 129-74-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors was written by Heinke, Ralf;Spannhoff, Astrid;Meier, Rene;Trojer, Patrick;Bauer, Ingo;Jung, Manfred;Sippl, Wolfgang. And the article was included in ChemMedChem in 2009.Reference of 129-74-8 This article mentions the following:

Lysine and arginine methyltransferases participate in the posttranslational modification of histones and regulate key cellular functions. Protein arginine methyltransferase 1 (PRMT1) has been identified as an essential component of mixed lineage leukemia (MLL) oncogenic complexes, revealing its potential as a novel therapeutic target in human cancer. The first potent arginine methyltransferase inhibitors were recently discovered by random- and target-based screening approaches. Herein we report virtual and biol. screening for novel inhibitors of PRMT1. Structure-based virtual screening (VS) of the Chembridge database composed of 328 000 mols. was performed with a combination of ligand- and target-based in silico approaches. Nine inhibitors were identified from the top-scored docking solutions; these were exptl. tested using human PRMT1 and an antibody-based assay with a time-resolved fluorescence readout. Among several aromatic amines, an aliphatic amine and an amide were also found to be active in the micromolar range. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Reference of 129-74-8).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 129-74-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics