511254-92-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.511254-92-5,(S)-1-Benzyl-2-methylpiperazine,as a common compound, the synthetic route is as follows.
Step 3. (S)-tert-Butyl 4-(4-benzyl-3-methylpiperazin-1-yl)-4-cyanopiperidine-1-carboxylate (24). To a stirred solution of 22 (21.22 g, 111.52 mmol) in dichloromethane (65 mL) was added 1-Boc-4-piperidone (23) (22.22 g, 111.52 mmol) in one portion. Titanium tetraisopropoxide (45.75 mL, 44.38 g, 156.13 mmol) was added dropwise over 30 minutes while the mixture was agitated with a mechanical stirrer at room temperature. After 21 hours, tetrahydrofuran (115 mL) was added. A 1.0 M solution of diethylaluminum cyanide (117.10 mL, 117.10 mmol) was added dropwise over 20 minutes. The mixture was stirred at room temperature for 20 hours then cooled to 0 C. Ethyl acetate (113 mL) was added dropwise over 10 minutes. Celite (11 g) was added, followed by sodium bicarbonate (47 g) and saturated aqueous sodium sulfate solution (11 mL) over 20 minutes. Methanol (70 mL) was added and the mixture was filtered through Celite and concentrated under reduced pressure to give 36.94 g (83%) of 24 as a beige, waxy solid.
The synthetic route of 511254-92-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CoNCERT Pharmaceuticals, Inc.; US2009/270336; (2009); A1;,
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