Tag: 5308-25-8

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-ethylpiperazine (3.40g, 29.8mmol), 80 K2CO3 (4.10g, 29.6mmol), and 93 TBAI (0.42g, 1.2mmol) were added to a solution of 82 5-bromo-2-nitropyridine (4.00g, 19.7mmol) in 83 DMSO (40mL). The mixture was heated at 80C for 16h, and the reaction was poured into ice water, and extracted with DCM. The combined organic layers were washed with water, dried over anhydrous Na2SO4, concentrated under a vacuum, and purified by silica gel column chromatography (DCM/MeOH=100:1-10:1) to obtain 94 1-ethyl-4-(6-nitropyridin-3-yl)piperazine (3.59g; yield, 56%) as a yellow solid. Pd/C (0.10g) was added to the 1-ethyl-4-(6-nitropyridin-3-yl)piperazine (0.90g, 3.8mmol) in EA/MeOH (9 mL/9mL) solution. The mixture was degassed by H2, stirred at RT under a H2 atmosphere for 2h, and filtered and concentrated under a vacuum to obtain INT-2 (720.0mg; yield, 92%) as an off-white solid. ESI-MS: m/z 207.2 [M+H]+.

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Article; Yin, Lei; Li, Heng; Liu, Wenjian; Yao, Zhenglin; Cheng, Zhenzhen; Zhang, Huabei; Zou, Hui; European Journal of Medicinal Chemistry; vol. 144; (2018); p. 1 – 28;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1 mole of 1-ethyl piperazine was dissolved in acetone and to it 3 moles of potassium carbonate was added with constant stirring. After 30 min, 1.5 mole of 1-bromo-3-chloropropane was added in drop wise manner and stirred for 12 h at RT. Later, solvent was evaporated from the reaction mixture and transferred to separating funnel having water and ethyl acetate. Organic layer was collected and evaporated to get 1-(3-chloropropyl)-4-ethylpiperazine asoily liquid. Yield 85%, IR (KBr, cm-1), 2954-2858 (Aliphatic CH str), 1350-1365 (-CN str); 1H NMR (400 MHz, Chloroform-d) delta 3.54 (t, J = 4.0 Hz, 2H), 3.16 – 3.06 (m,2H), 3.10 – 2.99 (m, 2H), 2.63 – 2.54 (m, 8H), 1.94 (tt, J =6.3, 4.0 Hz, 2H), 1.08 – 1.01 (m, 3H).

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Article; Singh, Mahaveer; Jadhav, Hemant R.; Kumar, Amit; Letters in drug design and discovery; vol. 15; 8; (2018); p. 866 – 874;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.36 g of N- [4-tert-butyl-5- (4-methoxybenzylthiazolyl) -2-yl] -2-chloroacetamideAnd 5 mL of tetrahydrofuran were added and stirred at room temperature, 0.24 g of pyridine and 0.23 g were added N-ethylpiperazine; reaction overnight, desolvation, plus dichloromethane,Saturated with salt water, dried over anhydrous sodium sulfate,Plus petroleum ether precipitation solid, suction filter, petroleum ether wash,Dried to give a pale yellow solidN- [4-tert-butyl-5- (4-methoxybenzylthiazolyl) -2-yl]2- (N-ethylpiperazinyl) acetamide in a yield of 65.1%

The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hunan University; Hu Aixi; Ding Na; Ye Jiao; (15 pag.)CN106938989; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics