Tag: 541.4574

Iwamoto, Takahiro et al. published their research in Japanese Journal of Pharmacology in 1992 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Computed Properties of C27H32Cl2F2N2O3

Effects of KB-2796, a new diphenylpiperazine calcium antagonist, on renal hemodynamics and urine formation in anesthetized dogs was written by Iwamoto, Takahiro;Morita, Tominori;Sukamoto, Takayuki;Ito, Keizo. And the article was included in Japanese Journal of Pharmacology in 1992.Computed Properties of C27H32Cl2F2N2O3 This article mentions the following:

The effects of KB-2796, a new calcium antagonist with a diphenylpiperazine moiety, on renal hemodynamics and urine formation were investigated in anesthetized dogs. I.v. infusion of KB-2796 (10, 30, and 100 μg/kg/min) decreased mean blood pressure (MBP) and renal vascular resistance (RVR) in a dose-dependent manner, but did not change renal blood flow (RBF). At the highest dose, glomerular filtration rate (GFR) and urine flow (UF) tended to decrease. Nicardipine (0.1, 0.3, and 1 μg/kg/min) also dose-dependently decreased MBP, RVR, GFR, and UF. When KB-2796 was infused into the renal artery at lower doses of 3 and 10 μg/kg/min, UF and urinary excretion of electrolytes increased without a significant change in RBF and GFR. Intrarenal infusion of KB-2796 at 30 μg/kg/min and nicardipine at 0.3 μg/kg/min produced a significant increase in GFR, RBF, UF, urinary excretion of electrolytes, and renin secretion rate. These results suggest that KB-2796 administered intrarenally exerts a diuretic action via tubular effects and the alteration of renal hemodynamics. However, its diuretic action might be masked by diminished urine formation via a reflex activation of the sympathetic nerves and/or via a reduction of renal perfusion pressure when it is administered systemically. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Computed Properties of C27H32Cl2F2N2O3).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Computed Properties of C27H32Cl2F2N2O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Oda, Ituki et al. published their research in Neuroscience Research (Shannon, Ireland) in 2022 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C27H32Cl2F2N2O3

Hemiplegic migraine type 2 with new mutation of the ATP1A2 gene in Japanese cases was written by Oda, Ituki;Danno, Daisuke;Saigoh, Kazumasa;Wolf, Johanna;Kawashita, Norihito;Hirano, Makito;Samukawa, Makoto;Kitamura, Shigekazu;Kikui, Shoji;Takeshima, Takao;Mitsui, Yoshiyuki;Kusunoki, Susumu;Nagai, Yoshitaka. And the article was included in Neuroscience Research (Shannon, Ireland) in 2022.Electric Literature of C27H32Cl2F2N2O3 This article mentions the following:

We analyzed the clin. symptoms of hemiplegic migraine (HM) and their relevance in four Japanese patients considered to have ATP1A2 mutations as a cause. Sequencing of ATP1A2 was performed using the Sanger method in 43 blood samples from clin. suspected patients with familial HM. Subsequently, algorithm anal., allele frequency determination, and three-dimensional structure anal. of the recognized variants were performed, and the recognized variants were evaluated. We found four heterozygous missense mutations in ATP1A2 (Case 1: p.R51C; Case 2: p.R65L; Case 3: p.A269P; Case 4: p.D999H), three of which had not been reported to date. These four mutations may also affect the structure of the protein products, as assessed using a three-dimensional structural anal. In all four cases, the clin. symptoms included visual, sensory, motor, and verbal symptoms and the frequency and duration of headache attacks varied. Addnl., oral administration of a combination of lomerizine hydrochloride and topiramate had a partial effect in three cases. We report four missense mutations in ATP1A2. This report will be useful for the future anal. of mutations and clin. types in Asians, as well as Westerners, with migraine. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Electric Literature of C27H32Cl2F2N2O3).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C27H32Cl2F2N2O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Shiino, Akihiko et al. published their research in Archiv fuer Japanische Chirurgie in 1989 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.SDS of cas: 101477-54-7

Experimental studies on pharmacological protection of the brain against focal ischemia. 2. Effects of KB-2796 and nicardipine on focal brain ischemia in rats was written by Shiino, Akihiko. And the article was included in Archiv fuer Japanische Chirurgie in 1989.SDS of cas: 101477-54-7 This article mentions the following:

It has been proposed that calcium overload triggers neuronal cell damage in the acute stage of cerebral ischemia. In this study, the effects of calcium antagonists, KB-2796 and nicardipine, on neurol. deficits and size of the infarction were studied in the rat middle cerebral artery (MCA) occlusion model. Neurol. deficits were evaluated from 1 to 24 h after occlusion of the MCA, using the grading system of Bederson et al., 1986. At 24 h post-occlusion, the brain was removed, sliced coronally, and stained with triphenyltetrazolium chloride. Size of the infarction was measured by computerized image anal. system. KB-2796 (10 mg/kg) or nicardipine (1 mg/kg) was i.p. administered immediately after occlusion of the MCA. In the KB-2796-treated group, the neurol. deficits were much improved and the size of infarction was significantly smaller, but in the nicardipine-treated group improvement was modest and did not reach the level of statistical significance. The neurol. improvement was observed in the group where KB-2796 was given at 3 h postocclusion but the size of infarction was unchanged. The results indicate that the calcium antagonists could improve focal cerebral ischemia when administered in early stage of ischemia, and that such effect is more significant with KB-2796 probably because of its higher selectivity to the cerebral vessels. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7SDS of cas: 101477-54-7).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.SDS of cas: 101477-54-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Liu, Min-hong et al. published their research in Yaoxue Jinzhan in 2005 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 101477-54-7

Preparation and quality control of lomerizine hydrochloride capsules was written by Liu, Min-hong;Ding, Jian;Yao, Xiao-min;Li, Chen. And the article was included in Yaoxue Jinzhan in 2005.Reference of 101477-54-7 This article mentions the following:

A method for the preparation and quality control of lomerizine hydrochloride capsules was established. The preparation method for the capsules has been improved and the stability was also studied. The amount of lomerizine hydrochloride in capsules was determined by HPLC with an average recovery 99.7% (RSD=0.64%). The preparation procedure for lomerizine hydrochloride capsules is practicable and the quality control methods are reliable. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Reference of 101477-54-7).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 101477-54-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Morita, Tominori et al. published their research in Oyo Yakuri in 1993 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application of 101477-54-7

Effects of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796) on cerebral circulation in dogs was written by Morita, Tominori;Iwamoto, Takahiro;Harada, Kengo;Hara, Hideaki;Sukamoto, Takayuki;Ito, Keizo;Nurimoto, Seiichi. And the article was included in Oyo Yakuri in 1993.Application of 101477-54-7 This article mentions the following:

The effects of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796, I), a new calcium antagonist, on cerebral circulation were studied in anesthetized dogs. KB-2796 increased the vertebral blood flow when injected into the vertebral artery (3-300 渭g/kg) or into the vein (30-1,000 渭g/kg) or introduced into the duodenum (3 or 10 mg/kg) in anesthetized dogs. KB-2796 was more potent than flunarizine and papaverine in increasing the flow rate. The duration of action of KB-2796 was longer than that of papaverine and compatible to that of flunarizine. The effect of KB-2796 injected into the vertebral artery in increasing the vertebral blood flow was not affected by pretreatment with propranolol, atropine, chlorpheniramine or aminophylline in anesthetized dogs. Furthermore, KB-2796 (i.v.) did not potentiate the effect of adenosine. KB-2796 (0.1 and 0.3 mg/kg, i.v.) and flunarizine (1 mg/kg, i.v.) increased the cerebral blood flow without modifying cerebral oxygen consumption in pancronium-immobilized anesthetized dogs. The results suggest that KB-2796 increases the cerebral blood flow presumably through vasodilation of the cerebral vessels by blocking calcium channels. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Application of 101477-54-7).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application of 101477-54-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Xu, Changsheng et al. published their research in Zhongguo Yaoke Daxue Xuebao in 2002 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Formula: C27H32Cl2F2N2O3

Synthesis of lomerizine dihydrochloride was written by Xu, Changsheng;Chen, Guohua;Luo, Xiaochuan. And the article was included in Zhongguo Yaoke Daxue Xuebao in 2002.Formula: C27H32Cl2F2N2O3 This article mentions the following:

Lomerizine dihydrochloride, a calcium antagonist used as antimigraine drug, was synthesized by methylating pyrogallic acid with di-Me sulfate to afford 1,2,3-trimethoxybenzene, chloromethylating with paraformaldehyde to afford 2,3,4-trimethoxybenzyl chloride, substituting with bis(4-fluorobenzyl)methylpiperazine in presence of triethylamine. Lomerizine dihydrochloride was obtained with 43% overall yield from pyrogallic acid. The structure of the compound was confirmed by IR, 1H-NMR, MS, and elemental anal. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Formula: C27H32Cl2F2N2O3).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Formula: C27H32Cl2F2N2O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Yamashita, Akira et al. published their research in General Pharmacology in 1993 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Application In Synthesis of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Effects of a new diphenylpiperazine calcium antagonist, KB-2796, on cerebral ischemic neuronal damage in rats was written by Yamashita, Akira;Ozaki, Akio;Ikegami, Akira;Hayashi, Akemi;Hara, Hideaki;Sukamoto, Takayuki;Ito, Keizo. And the article was included in General Pharmacology in 1993.Application In Synthesis of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride This article mentions the following:

The effects of KB-2796, a new diphenylpiperazine calcium antagonist, on the mitochondrial dysfunction and energy metabolism deficits were examined in the ischemic rat brain. KB-2796 (30 mg/kg, p.o.), administered 60 min prior to decapitation, improved the reduced respiratory activity of mitochondria obtained from rat brain 5 min after decapitative ischemia. KB-2796 (30 mg/kg, p.o.), administered 60 min prior to ischemic insult, improved both the reductions in pyruvate and ATP and prevented increases in the lactate/pyruvate ratio induced by 30-min forebrain ischemia in rats with 4-vessel occlusion (4-VO). The effect of KB-2796 on local glucose utilization (LCGU) was examined by a quant. autoradiog. 2-[14C]deoxyglucose method in normal and 4-VO rats. Postischemic LCGU measured 24 h after reperfusion in the forebrain, in particular in the cortex, thalamus, geniculate body, hippocampus, caudate-putamen, nucleus accumbens, colliculus, and corpus callosum, was below the normal control value. KB-2796 (1 mg/kg, i.v.), administered 1 min prior to the injection of 2-[14C]deoxyglucose, improved the reductions in LCGU that were produced by cerebral ischemia in the cortex, thalamus, geniculate body, caudate-putamen, nucleus accumbens and substantia nigra, but did not affect LCGU in normal rats. These findings suggest that KB-2796 minimized the deficits in brain energy metabolism produced by ischemia; this agent may therefore be a valuable therapeutic drug in cerebrovascular-related disorders. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Application In Synthesis of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Application In Synthesis of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Yamashita, Akira et al. published their research in General Pharmacology in 1993 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Application In Synthesis of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Effects of a new diphenylpiperazine calcium antagonist, KB-2796, on cerebral ischemic neuronal damage in rats was written by Yamashita, Akira;Ozaki, Akio;Ikegami, Akira;Hayashi, Akemi;Hara, Hideaki;Sukamoto, Takayuki;Ito, Keizo. And the article was included in General Pharmacology in 1993.Application In Synthesis of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride This article mentions the following:

The effects of KB-2796, a new diphenylpiperazine calcium antagonist, on the mitochondrial dysfunction and energy metabolism deficits were examined in the ischemic rat brain. KB-2796 (30 mg/kg, p.o.), administered 60 min prior to decapitation, improved the reduced respiratory activity of mitochondria obtained from rat brain 5 min after decapitative ischemia. KB-2796 (30 mg/kg, p.o.), administered 60 min prior to ischemic insult, improved both the reductions in pyruvate and ATP and prevented increases in the lactate/pyruvate ratio induced by 30-min forebrain ischemia in rats with 4-vessel occlusion (4-VO). The effect of KB-2796 on local glucose utilization (LCGU) was examined by a quant. autoradiog. 2-[14C]deoxyglucose method in normal and 4-VO rats. Postischemic LCGU measured 24 h after reperfusion in the forebrain, in particular in the cortex, thalamus, geniculate body, hippocampus, caudate-putamen, nucleus accumbens, colliculus, and corpus callosum, was below the normal control value. KB-2796 (1 mg/kg, i.v.), administered 1 min prior to the injection of 2-[14C]deoxyglucose, improved the reductions in LCGU that were produced by cerebral ischemia in the cortex, thalamus, geniculate body, caudate-putamen, nucleus accumbens and substantia nigra, but did not affect LCGU in normal rats. These findings suggest that KB-2796 minimized the deficits in brain energy metabolism produced by ischemia; this agent may therefore be a valuable therapeutic drug in cerebrovascular-related disorders. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Application In Synthesis of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Application In Synthesis of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Liu, Min-hong et al. published their research in Yaoxue Jinzhan in 2005 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 101477-54-7

Preparation and quality control of lomerizine hydrochloride capsules was written by Liu, Min-hong;Ding, Jian;Yao, Xiao-min;Li, Chen. And the article was included in Yaoxue Jinzhan in 2005.Reference of 101477-54-7 This article mentions the following:

A method for the preparation and quality control of lomerizine hydrochloride capsules was established. The preparation method for the capsules has been improved and the stability was also studied. The amount of lomerizine hydrochloride in capsules was determined by HPLC with an average recovery 99.7% (RSD=0.64%). The preparation procedure for lomerizine hydrochloride capsules is practicable and the quality control methods are reliable. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Reference of 101477-54-7).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 101477-54-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Morita, Tominori et al. published their research in Oyo Yakuri in 1993 | CAS: 101477-54-7

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application of 101477-54-7

Effects of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796) on cerebral circulation in dogs was written by Morita, Tominori;Iwamoto, Takahiro;Harada, Kengo;Hara, Hideaki;Sukamoto, Takayuki;Ito, Keizo;Nurimoto, Seiichi. And the article was included in Oyo Yakuri in 1993.Application of 101477-54-7 This article mentions the following:

The effects of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796, I), a new calcium antagonist, on cerebral circulation were studied in anesthetized dogs. KB-2796 increased the vertebral blood flow when injected into the vertebral artery (3-300 μg/kg) or into the vein (30-1,000 μg/kg) or introduced into the duodenum (3 or 10 mg/kg) in anesthetized dogs. KB-2796 was more potent than flunarizine and papaverine in increasing the flow rate. The duration of action of KB-2796 was longer than that of papaverine and compatible to that of flunarizine. The effect of KB-2796 injected into the vertebral artery in increasing the vertebral blood flow was not affected by pretreatment with propranolol, atropine, chlorpheniramine or aminophylline in anesthetized dogs. Furthermore, KB-2796 (i.v.) did not potentiate the effect of adenosine. KB-2796 (0.1 and 0.3 mg/kg, i.v.) and flunarizine (1 mg/kg, i.v.) increased the cerebral blood flow without modifying cerebral oxygen consumption in pancronium-immobilized anesthetized dogs. The results suggest that KB-2796 increases the cerebral blood flow presumably through vasodilation of the cerebral vessels by blocking calcium channels. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Application of 101477-54-7).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application of 101477-54-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics