With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.
Step B 4-t-Butoxycarbonyl-2-ketopiperazine A mixture of 500 mg (5 mmol) of piperazinone, 1.2 g (5.5 mmol) of t-butyldicarbonate and 2 g of sodium chloride in 7.5 mL of water and 10 mL of chloroform was heated to reflux 4 hrs. The reaction mixture was cooled to room temperature and extracted with ethyl acetate. The combined ethyl acetate extracts were dried over anhydrous magnesium sulfate. Solvent removal gave a crude product which was purified on silica gel using 5% methanol in ethyl acetate as solvent to give 925 mg of the desired carbamate lactam as white solid. 1 H NMR (CDCl3): 1.46(s,9H); 3.37(m,2H); 3.62(m,2H); 4.08(s,2H), 5625-67-2
The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Merck & Co., Inc.; US5629322; (1997); A;,
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