Tag: 59878-57-8

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of (S) – 4 – (2-hydroxy-1-phenyl-ethylamine) – 5-methyl-pyrrolo [2,1-f] [1, 2, 4] triazine-6-carboxylic acid (100 mg, 0 . 32mmol) and 1-cyclopropanecarboxylic formyl piperazine (74 mg, 0 . 48mmol) dissolved in N, N-dimethyl formamide (8 ml) in, then add 1-hydroxy benzotriazole (52 mg, 0 . 39mmol), 1-ethyl-3 – (3-dimethylamino-propyl) carbodiimide hydrochloride (74 mg, 0 . 39mmol) and triethylamine (98 mg, 0 . 96mmol), stirring the mixture at room temperature until the TLC reaction monitoring raw material the reaction is complete, to be added in to the reaction solution (100 ml), ethyl acetate (50 ml ¡Á 3) extraction, then by saturated sodium chloride solution (100 ml ¡Á 2) washing, the organic phase is dried with anhydrous sodium sulfate, concentrated under reduced pressure, the resulting residue is purified with silica gel column chromatography, to obtain (S) – (4-cyclopropyl carbonyl-piperazine-1-yl) – [4 – (2-hydroxy-1-phenyl-ethylamine) – 5-methyl-pyrrolo [2,1-f] [1, 2, 4] triazin-6-yl]-methyl ketone (99 mg, white solid), yield: 69.0%.

59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; SHANGHAI CDYMAX PHARMACEUTICALS CO LTD; An, XiaoXia; Bie, PingYan; Yang, wuli; Liu, Jun; (49 pag.)CN103848833; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of acid (0.33mmol) in DMF (2mL), diisopropylethylamine (0.33mmol) and HATU (0.33mmol) were added. The mixture was left 33h stirring at room temperature and then the appropriate amine (0.45mmol) was added. After 16h at room temperature the solvent was removed under reduced pressure; the residue was dissolved in 2mL of DCM and washed with 2mL of 0.4N Na2CO3 solution. The organic layer was separated, dried over Na2SO4 and the solvent removed under reduced pressure.

As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

Reference£º
Article; Nencini, Arianna; Pratelli, Carmela; Quinn, Joanna M.; Salerno, Massimiliano; Tunici, Patrizia; De Robertis, Alessandra; Valensin, Silvia; Mennillo, Federica; Rossi, Marco; Bakker, Annette; Benicchi, Tiziana; Cappelli, Federico; Turlizzi, Elisa; Nibbio, Martina; Caradonna, Nicola P.; Zanelli, Ugo; Andreini, Matteo; Magnani, Matteo; Varrone, Maurizio; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 526 – 545;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.

[5681 ] 3-(2-bromoethyl)- l-(4-(5-(difluoromethyl)-1 ,4-oxadiazol-2-y )-2-fluorobenzyl)- l-p henylurea (0.050 g, 0.107 mmol) and cyclopropyl(piperazin- l-yl)methanone (0.018 g, 0.1 17 mmol) were mixed at the room temperature in acetonitrile ( 1 mL) and then stirred at 100 C for 18 hr and cooled down to the room temperature to terminate the reaction. Then, water was added to the reaction mixture, followed by extraction with dichloromethane. The bi-phasic mixture was passed through a plastic frit to remove the solid residues and aqueous layer, and the organic layer collected was concentrated in vacuo. The concentrate was purified and concentrated by column chromatography (Si02 plate, 20x20x 1 mm; methanol / dichloromethane = 10 %) to give 3-(2-(4-(cyclopropanecarbonyl)piperazin-l -yl)ethyl)-l-(4-(5-(difluoromethyl)- l ,3,4-ox adiazol-2-yl)-2-fluorobenzyl)- l -phenylurea as white foam (0.024 g, 41.5 %). [5682] NMR (700 MHz, CDC13) delta 7.89 (dd, 1 H, J = 8.0, 1.7 Hz), 7.75 – 7.68 (m, 2H), 7.43 – 7.38 (m, 2H), 7.37 – 7.31 (m, 1 H), 7.21 – 7.16 (m, 2H), 6.93 (t, 1 H, 7 = 51.7 Hz), 5.06 (s, 3H), 3.44 (d, 4H, J = 34.7 Hz), 3.34 (q, 2H, J = 5.7 Hz), 2.45 (t, 2H, J = 6.0 Hz), 2.39 (s, 2H), 2.32 (s, 2H), 1.03 – 0.94 (m, 2H), 0.80 – 0.72 (m, 2H); LRMS (ES) m/z 543.3 (M+ + 1 ).

The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; KIM, Yuntae; LEE, Chang Sik; SONG, Hyeseung; GWAK, Dal-Yong; LEE, Jaeyoung; OH, Jung Taek; LEE, Chang Gon; KIM, II Hyang; (1041 pag.)WO2017/23133; (2017); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 200 mL reaction flask, ethyl 2-(2-(4-fluoro-3-carboxyphenyl)acetyl)benzoate (Formula I, R=Et) (5 g, 15.14 mmol)And acetonitrile (100mL), after the addition is completed, the system is stirred until the system is dissolved.Additional 1-cyclopropyl-formylpiperazine (2.57 g, 16.67 mmol) and EDCI (3.50 g, 18.31 mmol) were added.Subsequently, DIPEA (2.40 g, 18.5 mmol) was added dropwise to the system, and the reaction temperature was controlled to be no higher than 35 C during the dropwise addition.After the addition was completed, the system was kept at 30 ¡À 5 C overnight. After the reaction is completed, the system removes the solvent under high vacuum.Ethyl acetate (150 mL) and H 2O (150 mL) were directly added to the residue, and the mixture was stirred, and the organic phase was separated.The aqueous phase was extracted twice with ethyl acetate (2¡Á100 mL), and the organic phase was combined.The residue was purified by column chromatography (ethyl acetate / n-heptane = 5 / 1-2 / 1) to give a pale yellow solid (formula IV, R = Et) (6.02g, 85.2%).

The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangsu Jun Ruo Pharmaceutical Co., Ltd.; Haimen Baikang Bio-pharmaceutical Co., Ltd.; Nanjing Jun Ruo Bio-pharmaceutical Institute Co., Ltd.; Wei Wanguo; Xu Zichen; Fang Xianjie; Zhu Xinlei; Liu Rufeng; Yi Mingyue; Zhou Chenglong; Liu Jie; Song Yaojie; (7 pag.)CN110078671; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics