Tag: 67455-41-8

67455-41-8,67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Argon was passed through the suspension of bis-chloride (1) (0.419 g, 1 mmol) in dry pyridine(15 mL) at room temperature over 15 min. Amine (2.5 mmol) was added and the reaction mixture wasbubbled with argon for a further 15 min. The mixture was then stirred at room temperature for 7 days.The solid product was filtered off and washed with dry ether. The raw product was purified throughrecrystallization from ethanol.

67455-41-8 4-(Piperazin-1-yl)aniline 422925, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Zieba, Andrzej; Latocha, Ma?gorzata; Sochanik, Aleksander; Nycz, Anna; Ku?mierz, Dariusz; Molecules; vol. 21; 11; (2016);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

A mixture of 4-(piperazin-l-yl)aniline (348 mg, 1.968 mmol), (E)-methyl 3-(2-(2-chloropyrimidin-5-yl)vinyl)-5-methoxybenzoate (600 mg, 1.968 mmol) and TFA (672 mg, 5.904 mmol) in propan-2-ol (30 mL) was stirred at 150 C for 40 min under microwave. The resulting mixture was concentrated, basified with ammonia water, purified via ISCO (DCM/MeOH) to afford the title compound as a yellow solid (320 mg, 36.6% yield). MS (m/z): 446.3(M+H)+.

67455-41-8 4-(Piperazin-1-yl)aniline 422925, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; ZHANG, Weihan; LI, Jinshui; WO2014/139465; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics