Tag: 694499-26-8

694499-26-8,694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add (3-((3-(pyridin-3-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)thio)propanoic acid to a round bottom flask (50 mg) followed by N,N-dimethylformamide (5 ml), 4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (42 Mg), 2-(7-oxobenzotriazole)-N,N,N’,N’-tetramethylUrea hexafluorophosphate (74 mg) and triethylamine (0.05 ml). The reaction system was stirred at room temperature for 14 hours under argon atmosphere. anti-After completion, the solvent was evaporated to dryness under reduced pressure. Organic phase with water,After washing with saturated brine, it was dried over anhydrous sodium sulfate. The organic phase is filtered and evaporated to dryness under reduced pressure to give a crude material.Alkane (5 mL) was added in trifluoroacetic acid (1 mL). The reaction system was stirred at room temperature for 14 hours under argon atmosphere. After the reaction,The solvent was evaporated to dryness under reduced pressure and the mixture was diluted with water and then neutralized with saturated sodium hydrogen carbonate. Aqueous phase acetic acidThe organic layer was washed with water and saturated brine and dried over anhydrous sodium sulfate. The organic phase is filtered and steamed under reduced pressureAfter drying, get a rough product. The crude product was purified by purified silica gel column chromatography to afford purified compound 173.

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Hefei Matter Sciences Institute; Liu Jing; Liu Qingsong; Liu Xuesong; Wang Beilei; Jiang Zongru; Yu Kailin; Chen Cheng; Zou Fengming; Liu Qingwang; Liu Xiaochuan; Wang Wei; Wang Wenliang; Hu Chen; Wang Wenchao; Wang Junjie; Wang Li; (82 pag.)CN109942544; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred reaction mixture of XXVII (0.31 g, 0.99 mmol), V (0.27 g, 1 mmol), HATU (0.76 g, 2mmol) & DIPEA (0.646 g, 5 mmol) in DMF (5 mL) at RT for 16 h. Reaction mixture was diluted withwater and extracted with ethyl acetate (50 mL X 3), organic layer was washed with saturated brine solution(50 mL X 3), combined organic layer dried over anhydrous sodium sulphate, concentrated under vacuumto obtain crude which was purified by column chromatography using 100-200 silica gel (Eluent system-1% to 10 % MeOH: DCM) to obtain desired product XXVIII (0.200 g, 35%).LCMS: 575 [M+1]+

694499-26-8, As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.,694499-26-8

General procedure: To a solution of 3-iodo-4-methylbenzoyl chloride obtained above in dry DCM (10mL) at 0C was added Et3N (0.28mL, 2.0mmol) and 4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) aniline (328mg, 1.2mmol). The mixture was stirred at room temperature for 5h, and then the solvent was removed under reduced pressure. The residue was purified by using column chromatography to afford the corresponding product 6-1 (439mg, 2 steps yield: 85%).

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 8a-e (20 mmol) and triethylamine (40 mmol) indichloromethane (20 ml), a solution of 4a-f (1.5 eq) in dichloromethane(10 ml) was added dropwise at room temperature over20 min and stirred overnight. The mixture was washed with saturatedaqueous sodium bicarbonate and brine. After removing thesolvent under reduced pressure, the crude product was purifiedby flash chromatography on silica gel, eluting with dichloromethaneand methanol (10-30%), yielding the title compounds., 694499-26-8

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yao, Dahong; Wang, Jing; Wang, Guan; Jiang, Yingnan; Shang, Lei; Zhao, Yuqian; Huang, Jian; Yang, Shilin; Wang, Jinhui; Yu, Yamei; Bioorganic Chemistry; vol. 68; (2016); p. 112 – 123;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

After taking the two 50mL round bottom flask was added sequentially aniline compound 5 (1.10mmol), NaNO2 (2.21mmol), ultrapure water (20 mL), the system was cooled to 0 deg.] C, was slowly added dropwise HCl (3.30mmol) in 5mL aqueous solution The After the addition, maintain the temperature of the reaction system continue to react 1.5h. It was then slowly added dropwise an aqueous solution of NaN3 (1.32mmol). After the addition was complete, maintainingThe reaction temperature of the reaction system, 3h, TLC monitored the reaction. After completion of the reaction, a saturated NaHCO3 solution was added 20mL, extracted with ethyl acetate 30mL ¡Á 2, combined organic phases were dried over anhydrous Na2SO4, and concentrated to give azide 6 directly administered next.

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tianjin International Bio-pharmaceutical Joint Institute; Rao Zihe; Bai Cuigai; Yang Cheng; Chen Yue; Li Huiying; Wang Lei; Gao Yuan; Yang Juan; Sun Tao; Zhong Chuanke; (26 pag.)CN106749278; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

To the round bottom flask was added 3-iodo-4-methyl-benzoic acid (2.62 g, lOmmol), 10 ml of thionyl chloride and refluxed at 78 C for 4 hours. The rotary evaporator removed the volatile material to give 3-iodo- 4-methyl-benzoyl chloride. A solution of 4- (4-methylpiperazin-1-ylmethyl) -3-trifluoromethylaniline (2.27 g, 8.3 mmol), 3-iodo-4-methyl-benzoyl chloride (LOmmol), 15 ml of tetrahydrofuran, 10 ml of triethylamine and stirred at room temperature for 4 hours. Washed with saturated NaHC03 solution, extracted with ethyl acetate and water, washed with saturated NaCl solution, dried over anhydrous Na2S04, and the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column to give the title compound.

694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; NANJING SANHOME PHARMACEUTICAL CO., LTD.; WANG, YONG; ZHAO, LIWEN; CHEN, HONGYAN; ZHANG, DI; XU, XIN; ZHANG, CANG; ZHANG, HONGXING; (9 pag.)CN103664951; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics