Tag: 934-98-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

Step 2: 5-Bromo-3-((2-(4-methylpiperazin-l- yl)ethylamino) methyl) pyridin-2-amineTriethylamine (1.0 mL, 7.09 mmol) was added to a solution of 2-amino-5- bromonicotinaidehyde hydrobromide (1.0 g, 3.54 mmol) in methanol (24 mL) at room temperature. The reaction mixture was stirred for 10 minutes prior to the addition of 2-(4-methylpiperazin-l-yl)ethanamine (558 mg, 3.90 mmol). The reaction mixture was then stirred overnight and cooled to 0¡ãC. Sodium borohydride (201 mg, 5.32 mmol) was added portionwise at 0¡ãC and the reaction mixture was allowed to reach room temperature and stirred for 4 hours. After concentration to dryness, the residue was purified by chromatography on silica gel using dichloromethane/methanol/ammoniac (10 : 0 : 0.1 to 9 : 1 : 0.1) as eluent. The title product was obtained as a yellow solid (560 mg, 48percent).LCMS (ESI-APCI) m/z 328.1-330.1 (M + H)+

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis; WO2011/61214; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

The dichloropyrimidine (2.30 gm, 6.98 X 10″3 moles) was dissolved in methylene chloride and N-methyl-N’-(2-aminoethyl)piperazine (1.0 gm, 6.98 X 10″3 moles) was added. After stirring at room temperature for 1 hour, TLC (silica, 10percent methanol in methylene chloride) showed some remaining starting material (Rf = 0.91) along with a single product (Rf = 0.32). Diisopropylethylamine (0.902 gm, 1.22 mL, 6.98 X 10″3 moles) was added and this solution was heated at 45¡ãC. for 90 minutes. After cooling, the methylene chloride was removed under reduced pressure and the remaining material was purified by chromatography on silica using 15percent methanol in methylene chloride as eluent. The fractions containing the product were pooled and evaporated to provide 2.1 gm (69percent>) of the product as an orange solid.

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; JANUS BIOTHERAPEUTICS, INC.; LIPFORD, Grayson, B.; ZEPP, Charles, M.; WO2012/167053; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 6-nitrobenzo[d]oxazole-2-thiol (KR-200) (11.63 mmol, 2.28 g) in dichloromethane (465 mL) and oxalyl chloride (14.54 mmol, 1.25 mL) was placed under argon atmosphere and cooled to 0 ?C. Dimethylformamide (12 mL) was added drop wise over a period of 40 minutes. CAUTION: The addition of dimethylformamide should be conducted slowly to avoid rapid evolution of gas. The reaction was stirred for 30 minutes at 0 ?C, then ice bath was removed and the reaction was allowed to warm to room temperature. After two hours, the reaction was again cooled to 0 ?C and triethylamine (34.90 mmol, 4.87 mL) was added drop wise over a period of 25 minutes. Then 2-(4-methylpiperazin-1-yl)ethan-1-amine (KR-251) (12.80 mmol, 1.83 g) was added, and the ice bath was removed. The reaction was stirred for sixteen hours at room temperature then concentrated in vacuo yielding a red solid. Silica gel column chromatography of the solid (10:1 dichloromethane/methanol) provided pure KR-202251 as a yellow powder in a 53percent yield.

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Rynearson, Kevin D.; Charrette, Brian; Gabriel, Christopher; Moreno, Jesus; Boerneke, Mark A.; Dibrov, Sergey M.; Hermann, Thomas; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3521 – 3525;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics