Tag: M.W:100-200

Synthetic Route of C9H7NO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of novel substituted 1,3-diarylpropenone derivatives and their in vitro cytotoxic activity. Author is Ivanova, Yordanka; Momekov, Georgi; Petrov, Ognyan.

The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone (I), its N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3H)-benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3H)-benzoxazolone was also synthesized and its influence on cytotoxic activity was investigated.

The article 《Synthesis of novel substituted 1,3-diarylpropenone derivatives and their in vitro cytotoxic activity》 also mentions many details about this compound(54903-09-2)Synthetic Route of C9H7NO3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new cationic BINAP-ruthenium(II) complexes and their use in asymmetric hydrogenation [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]》. Authors are Mashima, Kazushi; Kusano, Kohhei; Ohta, Tetsuo; Noyori, Ryoji; Takaya, Hidemasa.The article about the compound:(S)-Methyl 3-hydroxybutanoatecas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O).Quality Control of (S)-Methyl 3-hydroxybutanoate. Through the article, more information about this compound (cas:53562-86-0) is conveyed.

Reaction of [RuX2(arene)]2 with (S)-BINAP gives cationic BINAP-ruthenium complexes I (X = Cl, Br, iodo; Z = Cl, Br, iodo, BF4, BPh4; arene = C6H6, p-MeC6H4CHMe2) which are efficient catalyst precursors for enantioselective hydrogenation of various prochiral alkenic and ketonic substrates; a crystal structure of I (X = Cl, Z = BF4) was obtained.

The article 《Synthesis of new cationic BINAP-ruthenium(II) complexes and their use in asymmetric hydrogenation [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]》 also mentions many details about this compound(53562-86-0)Quality Control of (S)-Methyl 3-hydroxybutanoate, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Spectroscopic and optoelectronic investigations of 3,8-bis(3,4-(ethylenedioxy)thien-2-yl)-1,10-phenanthroline, the main research direction is ethylenedioxythien phenanthroline Spectroscopy optoelectronics.Application of 66-71-7.

1,10-Phenanthroline-based luminescent materials play an important role as an excellent class of optoelectronic materials due to their remarkable and novel attributes for optoelectronic applications. There is an enormous demand of luminescent materials in many fields. The foremost objective of this paper is to synthesize fluorescent derivatives of 1,10-phenanthroline. The electronic effect of the substituents on the heteroaromatic ligand has been reviewed in solid state. These ligands were characterized by electrochem. study and spectroscopically. The value of energy band gap is estimated to be 3.0-4.5 eV for synthesized compounds Photophys. features were analyzed through photoluminescence spectrometer, which indicates a strong impact of the substituents on the photoluminescent properties of the phenanthroline ligand. Upon excitation in UV region, intense broad band appeared in emission spectra of synthesized compounds lie in visible region which is further supported by CIE color coordinates. The detailed explanation about the geometry and frontier MOs calculation was carried out with the help of Avogadro and ORCA software.

The article 《Spectroscopic and optoelectronic investigations of 3,8-bis(3,4-(ethylenedioxy)thien-2-yl)-1,10-phenanthroline》 also mentions many details about this compound(66-71-7)Application of 66-71-7, you can pay attention to it, because details determine success or failure

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about DMSO/t-BuONa/O2-Mediated Aerobic Dehydrogenation of Saturated N-Heterocycles, the main research direction is quinoline preparation; tetrahydroquinoline sodium tert butoxide dimethyl sulfoxide oxidative dehydrogenation; isoquinoline preparation; tetrahydroisoquinoline sodium tert butoxide dimethyl sulfoxide oxidative dehydrogenation; indole preparation; indoline sodium tert butoxide dimethyl sulfoxide oxidative dehydrogenation.Application of 2343-22-8.

Aromatic N-heterocycles such as quinolines I [R1 = H, 8-Cl, 6-OMe, etc.; R2 = H, 3-Me, 4-Ph, etc. X = N; Y = CH2], isoquinolines I [R1 = H; R2 = H, 1-Ph; X = CH2; Y = N] and indoles II [R1 = H, 5-F, 4-Br, etc.; R2 = H, 2-Me; Y = CH2, N] were synthesized via a sodium tert-butoxide promoted oxidative dehydrogenation of the saturated heterocycles in DMSO solution This reaction proceeded under mild reaction conditions with a good functional group tolerance. Mechanistic studies suggested a radical pathway involved hydrogen abstraction of dimsyl radicals from the N-H bond or α-C-H of the substrates, and subsequent oxidation of the nitrogen or α-aminoalkyl radicals.

The article 《DMSO/t-BuONa/O2-Mediated Aerobic Dehydrogenation of Saturated N-Heterocycles》 also mentions many details about this compound(2343-22-8)Application of 2343-22-8, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Convenient preparation of BINAP-ruthenium(II) complexes for catalyzing the asymmetric hydrogenation of functionalized ketones.Computed Properties of C5H10O3.

Ligand exchange between [RuCl2(benzene)]2 or RuCl2[Sb(C6H5)3]3 and (R)- or (S)-BINAP [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene] produces BINAP-Ru(II) complexes which act as catalysts for the highly enantioselective hydrogenation of functionalized ketones, e.g., AcCH2CO2Me to R-MeCH(OH)CH2CO2Me.

The article 《Convenient preparation of BINAP-ruthenium(II) complexes for catalyzing the asymmetric hydrogenation of functionalized ketones》 also mentions many details about this compound(53562-86-0)Computed Properties of C5H10O3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Asymmetric reactions catalyzed by chiral metal complexes. XLIX. Synthesis of atropisomeric biphenylbisphosphine. 6,2′-Bis(diphenylphosphino)-3-methoxy-2,4-dimethyl-4′,6′-bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and its use in ruthenium(II)-catalyzed asymmetric hydrogenation of a 3-oxo ester, published in 1991-11-30, which mentions a compound: 53562-86-0, mainly applied to asym hydrogenation oxobutanoate catalyst biphenylbisphosphineruthenium; atropisomeric biphenylbisphosphine ligand synthesis, Quality Control of (S)-Methyl 3-hydroxybutanoate.

New atropisomeric biphenylbisphosphines, 6,2′-bis(diphenylphosphino)-3-methoxy-2,4-dimethyl-4′,6′-bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and 2,2′-bis(diphenylphosphino)-4,4′,6,6′-tetrakis(trifluoromethyl)-1,1′-biphenyl (BIFUP), were prepared from 2,3,5-Br(CF3)2C6H2NO2. The FUPMOP-Ru(II) complex was an excellent catalyst for the asym. hydrogenation of MeCOCH2CO2Me.

The article 《Asymmetric reactions catalyzed by chiral metal complexes. XLIX. Synthesis of atropisomeric biphenylbisphosphine. 6,2′-Bis(diphenylphosphino)-3-methoxy-2,4-dimethyl-4′,6′-bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and its use in ruthenium(II)-catalyzed asymmetric hydrogenation of a 3-oxo ester》 also mentions many details about this compound(53562-86-0)Quality Control of (S)-Methyl 3-hydroxybutanoate, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Photochemical reactions of N-2,3-dihydrobenzoxazol-2-ones, published in 1979-04-30, which mentions a compound: 54903-09-2, Name is 6-Acetylbenzo[d]oxazol-2(3H)-one, Molecular C9H7NO3, Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.

Photo-Fries rearrangements of N-acyl-2,3-dihydrobenzoxazol-2-ones (I; R = Ac, COEt, COPr, COCHMe2, Bz, COC6H4Me-p) are described. Irradiation of I in MeCN afforded a mixture of 2-acyl-2,3-dihydrobenzoxazol-2-one and 6-acyl-2,3-dihydrobenzoxazol-2-one together with other minor products. However, I (R = H, Me) were very photostable. The reaction scheme involving Norrish type I dissociation is discussed.

The article 《Photochemical reactions of N-2,3-dihydrobenzoxazol-2-ones》 also mentions many details about this compound(54903-09-2)Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C9H7NO3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones. Author is Ivanova, Yordanka B.; Momekov, Georgi T.; Petrov, Ognyan I..

A number of chalcones bearing an oxazole cycle I (R1 = R2 = R3 = R4 = H, OCH3; X, Y = O, NH) were synthesized by Claisen-Schmidt condensation of 5-acetyl-2(3H)-benzoxazolone or 6-acetyl-2(3H)-benzoxazolone with appropriate aldehydes. The chalcones were evaluated for cytotoxic activity against several tumor cell lines – BV-173 (human B cell precursor leukemia), MCF-7 and MDA-MB-231 (human breast adenocarcinoma) using the MTT-dye reduction assay. The tested compounds exhibit concentration-dependent cytotoxic effects at micromolar concentrations Exposure of the BV-173 tumor cell line to compound I (R1 = H; R2 = R3 = R4 = OCH3; X = NH; Y = O) results in strong mono- and oligonucleosomal fragmentation of genomic DNA, as evidenced by a ‘cell death detection’ ELISA kit, which unambiguously indicates that the induction of apoptosis is implicated in the cytotoxic mode of action of the tested compound

The article 《New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones》 also mentions many details about this compound(54903-09-2)Electric Literature of C9H7NO3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Discovery of Novel Thiazole Carboxamides as Antifungal Succinate Dehydrogenase Inhibitors, the main research direction is thiazole carboxamide preparation antifungal succinate dehydrogenase inhibitor; fungicide; molecular docking; succinate dehydrogenase inhibitor; thiazole carboxamide.Category: piperazines.

To contribute mol. diversity for novel fungicide development, a series of novel thiazole carboxamides were rationally designed, synthesized, and characterized with the succinate dehydrogenase (SDH) as target. Bioassay indicated that compound 6g showed the similar excellent SDH inhibition as that of Thifluzamide with IC50 of 0.56 mg/L and 0.55 mg/L, resp. Some derivatives displayed improved in vitro fungicidal activities against Rhizoctonia cerealis and Sclerotinia sclerotiorum with EC50 of 1.2-16.4 mg/L and 0.5-1.9 mg/L. Surprisingly, 6g showed promising in vitro fungicidal activities against R. cerealis and S. sclerotiorum with EC50 of 6.2 and 0.6 mg/L, resp., which was superior to Thifluzamide with the EC50 of 22.1 and 4.4 mg/L, resp. Addnl., compounds 6c and 6g displayed excellent in vivo fungicidal activities against S. sclerotiorum on Brassica napus L. leaves with protective activity of 75.4% and 67.3% at 2.0 mg/L, resp., while Thifluzamide without activity at 5.0 mg/L. Transcriptomic anal. of S. sclerotiorum treated with 6g by RNA sequencing indicated the down-regulation of succinate dehydrogenase gene SDHA and SDHB, and the inhibition of the TCA-cycle.

The article 《Discovery of Novel Thiazole Carboxamides as Antifungal Succinate Dehydrogenase Inhibitors》 also mentions many details about this compound(2343-22-8)Category: piperazines, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Fu, Pengkun; Li, Yuyan; Qin, Tianrui; Li, Duqingcuo; Shi, Zhan; Xiong, Dingqi; Yang, Qinglin; Zhu, Yanyan; Dong, Xiuyan published an article about the compound: 1,10-Phenanthroline( cas:66-71-7,SMILESS:C1=CC3=C(C2=NC=CC=C12)N=CC=C3 ).Safety of 1,10-Phenanthroline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:66-71-7) through the article.

Three new complexes synthesized by hydrothermal method with 4-(3-Carboxy-phenoxy)-phthalic acid (H3L1) and 2-(4-Carboxy-benzyl)-terephthalic acid (H3L2) as main ligands, 1,10-phenanthroline (1,10-phen) 1,4-bis(1-imidazolyl)benzene(dib) and 1,4-di(pyridin-4-yl)benzene (4,4′-bipb) as auxiliary ligands: [Cd3(L1)2(1,10-phen)2·H2O]n (1), [Co(HL2)(dib)(H2O)2]n (2), [Co(HL2)(bipb)]n (3). Single-crystal X-ray diffraction shows that 1 belongs to the monoclinic system and the P-1 space group, 2 belongs to the monoclinic system and the P-1 space group, 3 belongs to the triclinic system and the P21/n space group. Complexes 1-3 are 1-D chain, 2-D network and 3-D structures, resp. Moreover, Hirshfeld surface anal. analyzed the intermol. interaction and surface electron distribution of 1-3. The photoluminescence properties of complex 1 and magnetic, electrochem. properties of complex 3 were studied.

Different reactions of this compound(1,10-Phenanthroline)Safety of 1,10-Phenanthroline require different conditions, so the reaction conditions are very important.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics