Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.,59702-07-7

A mixture of 8-bromo-1- (5-isopropyl-2,4-dimethoxybenzene) -5,6-dihydro-4H-benzo [f] [1,2,4] 4,3-a] azepine (100 mg, 0.23 mmol)1-methylpiperazin-2-one (51 mg, 0.45 mmol)(15 mg, 0.026 mmol), 4,5-dibenzophenylphosphine-9,9-dimethyloxacenene (15 mg, 0.026 mmol) and sodium tert-butoxide (48 mg , 0.50 mmol) was added to dry toluene (2 mL).Under nitrogen protection,Microwave heated to 100 ¡ã C,Reaction for 2 hours.The residue was purified by column chromatography (dichloromethane / methanol = 100: 0 to 90:10, v / v) to give 4- (1- (5-isopropyl-2,4-dimethoxy Benzo [f] [1,2,4] triazolo [4,3-a] azepin-8-yl) -1-methylpiperazine- 2-on4-(1-(5-isopropyl-2,4-dimethoxyphenyl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a]azepine-8-yl)-1-methylpiperazin-2-onee(80 mg) in 74percent yield.

The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Hansoh BioMedical Co., Ltd.; Zhao, Zhiming; Deng, Xiangjun; Huang, Zhiqiang; Yu, Hongping; Xu, Yaocahng; Pan, Zhongzong; Bao, Rudi; (62 pag.)CN106349241; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

57260-71-6, Step 1: To a solution containing compound 1 (3.9 g, 31 mmol) and Boc-piperazine (6.3 g, 34 mmol) in N-methyl-2-pyrrolidone (NMP) (30 ml) was added K2C03 (8.5 g, 62 mmol). The mixture was stirred overnight at 135 C. After completion of the reaction, the mixture was poured into ice water, and the precipitate was collected to afford the desired product as a yellow solid (6.4 g, 72%).

As the paragraph descriping shows that 57260-71-6 is playing an increasingly important role.

Reference£º
Patent; ACETYLON PHARMACEUTICALS, INC.; SHEARSTONE, Jeffrey, R.; JARPE, Matthew, B.; (152 pag.)WO2016/57779; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics