Tag: M.W=250-300

Dong, Yuyang; Schuppe, Alexander W.; Mai, Binh Khanh; Liu, Peng; Buchwald, Stephen L. published the artcile< Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl-Cu Species>, Quality Control of 197638-83-8, the main research area is vinyl hetero arene aldehyde ketone copper catalyst reductive coupling; hydroxy vinyl heteroarene regio diastereo enantioselective preparation.

A CuH-catalyzed regiodivergent coupling of vinyl heteroarenes with carbonyl-containing electrophiles, in which the selectivity was controlled by the ancillary ligand. This approach leverages an in situ generated benzyl- or dearomatized allyl-Cu intermediate, yielding either the dearomatized or exocyclic addition products, resp. The method exhibited excellent regio-, diastereo-, and enantioselectivity and tolerated a range of common functional groups and heterocycles. The dearomative pathway allowed direct access to a variety of functionalized saturated heterocyclic structures. The reaction mechanism was probed using a combination of exptl. and computational approach. D. functional theory studies suggested that the ligand-controlled regioselectivity results from the C-H/π interaction and steric repulsion in transition states leading to the major and minor regioisomers, resp. Hydrocupration of vinyl heteroarene pronucleophile was the enantiodetermining step, whereas the diastereoselectivity was enforced by steric interactions between the benzylic or allyl-Cu intermediate and carbonyl-containing substrates in a six-membered cyclic transition state.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Quality Control of 197638-83-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Baxter, Ellen W.; Reitz, Allen B. published the artcile< Reductive aminations of carbonyl compounds with borohydride and borane reducing agents>, Safety of 1-Boc-4-(4-Formylphenyl)piperazine, the main research area is review reductive amination carbonyl compound borohydride borane reducing agent.

A review of the article Reductive aminations of carbonyl compounds with borohydride and borane reducing agents.

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Safety of 1-Boc-4-(4-Formylphenyl)piperazine.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mondal, Milon; Unver, M. Yagiz; Pal, Asish; Bakker, Matthijs; Berrier, Stephan P.; Hirsch, Anna K. H. published the artcile< Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and -Optimization of Inhibitors of the Aspartic Protease Endothiapepsin>, Application of C16H22N2O3, the main research area is triazole protein templated click chem aspartic protease endothiapepsin inhibitor; click chemistry; drug design; enzymes; inhibitors; liquid chromatography.

There is an urgent need for the development of efficient methodologies that accelerate drug discovery. The authors demonstrate that the strategic combination of fragment linking/optimization and protein-templated click chem. is an efficient and powerful method that accelerates the hit-identification process for the aspartic protease endothiapepsin. The best binder, which inhibits endothiapepsin with an IC50 value of 43 μM, represents the first example of triazole-based inhibitors of endothiapepsin. The authors’ strategy could find application on a whole range of drug targets.

Chemistry – A European Journal published new progress about 1,3-Dipolar cycloaddition reaction. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Application of C16H22N2O3.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wang, Junwei; Wang, Xuyan; Li, Hui; Ji, Dezhong; Li, Yuyan; Xu, Yungen; Zhu, Qihua published the artcile< Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors>, Safety of 1-Boc-4-(4-Formylphenyl)piperazine, the main research area is fluorobenzimidazolecarboxamide preparation PARP1 inhibitor anticancer potentiation; Antitumor; Benzimidazole; Fluorine atom; Inhibitors; PARP-1.

Novel 5-fluorobenzimidazole-4-carboxamides were designed and synthesized. All target compounds were evaluated for their PARP-1 inhibitory activity. Compounds possessed high intrinsic PARP-1 inhibitory potency and were evaluated by in vitro cellular assays to measure their growth inhibitory activity as single agents against human colon cancer cell line HCT116 and their potentiation effect toward cytotoxic agent temozolomide (TMZ) against cancer cell line A549. One compound displayed strong inhibition against the PARP-1 enzyme with an IC50 of 43.7 nM, excellent cell inhibitory activity in HCT116 cells (IC50 = 7.4 μM) and potentiation of temozolomide cytotoxicity in cancer cell line A549 (PF50 = 1.6).

Bioorganic & Medicinal Chemistry Letters published new progress about Alveolar carcinoma. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Safety of 1-Boc-4-(4-Formylphenyl)piperazine.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Luesse, Sarah B.; Wells, Gregg; Miller, Jeanne; Bolstad, Erin; Bergmeier, Stephen C.; McMills, Mark C.; Priestley, Nigel D.; Wright, Dennis L. published the artcile< Synthesis of a functionalized oxabicyclo[2.2.1]heptene-based chemical library>, HPLC of Formula: 197638-83-8, the main research area is chem library oxabicycloheptane preparation antibacterial agent.

The 7-oxabicyclo[2.2.1]heptene ring system is a common structural motif in many pharmacol. interesting mols. The authors recognized the potential to employ this highly oxygenated and conformationally-restricted scaffold in diversity-oriented method to generate a library of non-chiral but topol. complex compounds and the synthesis of the target compounds was achieved by an acetalization cyclcocondensation of aldehydes with (exo,exo)-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dimethanol. Herein, the authors report the synthesis and biol. evaluation of two 96-member tricyclic library containing the oxabicyclo[2.2.1]heptene framework [6,9-epoxy-2,4-benzodioxepin derivatives, conformationally restricted acetals].

Combinatorial Chemistry & High Throughput Screening published new progress about Acetalization. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, HPLC of Formula: 197638-83-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Despras, Guillaume; Zamaleeva, Alsu I.; Dardevet, Lucie; Tisseyre, Celine; Magalhaes, Joao Gamelas; Garner, Charlotte; De Waard, Michel; Amigorena, Sebastian; Feltz, Anne; Mallet, Jean-Maurice; Collot, Mayeul published the artcile< H-Rubies, a new family of red emitting fluorescent pH sensors for living cells>, Product Details of C16H22N2O3, the main research area is H Rubies fluorescent hydrogen ion concentration sensor living cell.

Monitoring intracellular pH has drawn much attention due to its undeniably important function in cells. The widespread development of fluorescent imaging techniques makes pH sensitive fluorescent dyes valuable tools, especially red-emitting dyes which help to avoid the overcrowded green end of the spectral band. Herein, we present H-Rubies, a family of pH sensors based on a phenol moiety and a X-rhodamine fluorophore that display a bright red fluorescence upon acidification with pKa values spanning from 4 to 9. Slight structural modifications led to dramatic changes in their physicochem. properties and a relationship between their structures, their ability to form H-aggregates, and their apparent pKa was established. While mol. form H-Rubies can be used to monitor mitochondrial acidification of glioma cells, their functionalised forms were linked via click chem. to dextrans or microbeads containing a near IR Cy5 (Alexa-647) in order to provide ratiometric systems that were used to measure resp. the phagosomal and endosomal pH in macrophages (RAW 264.7 cells) using flow cytometry.

Chemical Science published new progress about Absorption spectra. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Product Details of C16H22N2O3.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Moreno-Cinos, Carlos; Sassetti, Elisa; Salado, Irene G.; Witt, Gesa; Benramdane, Siham; Reinhardt, Laura; Cruz, Cristina D.; Joossens, Jurgen; Van der Veken, Pieter; Brotz-Oesterhelt, Heike; Tammela, Paivi; Winterhalter, Mathias; Gribbon, Philip; Windshugel, Bjorn; Augustyns, Koen published the artcile< α-Amino diphenyl phosphonates as novel inhibitors of Escherichia coli ClpP protease>, Quality Control of 197638-83-8, the main research area is aminodiphenylphosphonate Escherichia ClpP protease inhibitor.

Increased Gram-neg. bacteria resistance to antibiotics is becoming a global problem, and new classes of antibiotics with novel mechanisms of action are required. The caseinolytic protease subunit P (ClpP) is a serine protease conserved among bacteria that is considered as an interesting drug target. ClpP function is involved in protein turnover and homeostasis, stress response, and virulence among other processes. The focus of this study was to identify new inhibitors of Escherichia coli ClpP and to understand their mode of action. A focused library of serine protease inhibitors based on diaryl phosphonate warheads was tested for ClpP inhibition, and a chem. exploration around the hit compounds was conducted. Altogether, 14 new potent inhibitors of E. coli ClpP were identified. Compounds 85 and 92 emerged as most interesting compounds from this study due to their potency and, resp., to its moderate but consistent antibacterial properties as well as the favorable cytotoxicity profile.

Journal of Medicinal Chemistry published new progress about Antibiotic resistance (overcoming). 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Quality Control of 197638-83-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

He, Longwei; Yang, Yunzhen; Lin, Weiying published the artcile< Rational Design of a Rigid Fluorophore-Molecular Rotor-Based Probe for High Signal-to-Background Ratio Detection of Sulfur Dioxide in Viscous System>, Quality Control of 197638-83-8, the main research area is rigid fluorophore mol rotor probe sulfur dioxide viscous.

Many viscous microenvironments exist in living systems. For instance, at the cellular level, the viscosity of subcellular organelles (mitochondria, lysosomes, endoplasmic reticulum, nucleus, etc.) is much greater than that of cytoplasm; at the organismal level, compared with normal states of health, blood, or lymphatic fluid viscosity will increase to some extent in diabetes, hypertension, inflammation, tumors, and so on. However, due to the design shortcoming, there is a lack of efficient tools for detecting biomols. in viscous living systems. Herein, we propose a rational design strategy for constructing ratiometric fluorescent probes with superior response signal-to-background (S/B) ratio in viscous systems based on rigid-fluorophore-mol. rotor platform, and a practical sulfur dioxide (SO2) probe (RFC-MRC) based on conmarin-cyanine dyad was prepared as a proof-of-concept. The probe performs a significant enhancement (71.5-fold) of ratiometric response signal stimulated by SO2 in viscous aqueous media. The cationic probe can selectively in mitochondria and was successfully utilized to sense SO2 in living HeLa cells through ratiometric fluorescence imaging. What’s more, in the fluorescence imaging experiments of monitoring SO2 in apoptotic cells using probe RFC-MRC, a more obvious superior of S/B ratio was observed in the early apoptotic cells than in the lately apoptotic cells.

Analytical Chemistry (Washington, DC, United States) published new progress about Fluorescent indicators. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Quality Control of 197638-83-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Li, Zhe; Gever, Joel R.; Rao, Satish; Widjaja, Kartika; Prusiner, Stanley B.; Silber, B. Michael published the artcile< Discovery and Preliminary Structure-Activity Relationship of Arylpiperazines as Novel, Brain-Penetrant Antiprion Compounds>, HPLC of Formula: 197638-83-8, the main research area is arylpiperazine antiprion neurodegenerative disease creutzfeldt jakob preparation; Creutzfeldt-Jakob disease; Neurodegenerative diseases; SAR; arylpiperazine; piperazine; prion disease.

Creutzfeldt-Jakob disease and kuru in humans, BSE in cattle, and scrapie in sheep are fatal neurodegenerative disorders. Such illnesses are caused by the conversion and accumulation of a misfolded pathogenic isoform (termed PrPSc) of a normally benign, host cellular protein, denoted PrPC. The authors employed high-throughput screening enzyme-linked immunosorbent assays to evaluate compounds for their ability to reduce the level of PrPSc in Rocky Mountain Laboratory prion-infected mouse neuroblastoma cells (ScN2a-cl3). Arylpiperazines were among the active compounds identified, but the initial hits suffered from low potency and poor drug-likeness. The best of those hits, such as 1-(4-(4-Benzylpiperazine-1-yl)phenyl)ethanone, 1-(4-(4-(3-pyridinylmethyl)-1-piperazinyl)phenyl)ethanone, 1-(4-(4-(2-thienylmethyl)-1-piperazinyl)phenyl)ethanone, and 1-(4-(4-[(5-methyl-2-furanyl)methyl]-1-piperazinyl)phenyl)ethanone, displayed moderate antiprion activity with EC50 values in the micromolar range. Key analogs were designed and synthesized on the basis of the structure-activity relationship, with analogs 2-(4-(4-(Pyridin-3-ylmethyl)piperazin-1-yl)phenyl)benzo[d]oxazole, 2-(4-(4-(Pyridin-3-ylmethyl)piperazin-1-yl)phenyl)benzo[d]thiazole, 2-(4-(4-((6-Fluoropyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole, and 2-(4-(4-((6-methoxypyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole found to have submicromolar potency. Analogs 2-(4-(4-(Pyridin-3-ylmethyl)piperazin-1-yl)phenyl)benzo[d]oxazole and 2-(4-(4-(Pyridin-3-ylmethyl)piperazin-1-yl)phenyl)benzo[d]thiazole were able to penetrate the blood-brain barrier and achieved excellent drug concentrations in the brains of mice after oral dosing. These compounds represent good starting points for further lead optimization in the authors’ pursuit of potential drug candidates for the treatment of prion diseases.

ACS Medicinal Chemistry Letters published new progress about Creutzfeldt-Jakob disease. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, HPLC of Formula: 197638-83-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Papagni, Antonio; Del Buttero, Paola; Bertarelli, Chiara; Miozzo, Luciano; Moret, Massimo; Pryce, Mary T.; Rizzato, Silvia published the artcile< Novel fluorinated amino-stilbenes and their solid-state photodimerization>, Quality Control of 197638-83-8, the main research area is fluorinated aminostilbene solid state photodimerization.

We synthesized a series of polyfluoroaminostilbenes in satisfactory yields by Wittig reaction of 4-piperazinylbenzalhehydes with pentafluorobenzylidenetriphenylphosphorane and we analyzed the photochem. behavior of these stilbenes in the solid state; thanks to arene-perfluoroarene π-π interactions, some of them have shown a good propensity to give the corresponding cyclobutane photodimers in quant. yields. The photocyclization is reversible both in solution and in polymeric matrix, affording the corresponding stilbenes with different cis-trans stereoselectivity.

New Journal of Chemistry published new progress about [2+2] Photocycloaddition reaction. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Quality Control of 197638-83-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics